Protective effect of hydrogen molecule learning and memory function in oxidative stress induced mice.
| Project/Area Number |
22500680
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
NISHIMAKI Kiyomi 日本医科大学, 老人病研究所, マネージメントサポートスタッフ (00465345)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 老化・加齢 / 酸化ストレス / 水素 / アルツハイマー病 / 加齢、老化 |
|---|
| Research Abstract |
Accumulation of oxidative stress associated with aging is one of causative factors in the pathogenesis of major neurodegenerative diseases including Alzheimer’ and Parkinson diseases (AD and PD). Hydrogen molecules(H2) are superior antioxidants, selectively reduced the hydroxyl radical,the most cytotoxic Ros, without affecting the other oxygen-derived free radicals. In this study, we investigated the effect of an antioxidant, hydrogen molecule (H2), using DAL mice as Alzheimer's disease animal model. We showed that the consumption of molecular hydrogen reduces brainoxidative stress levels and inhibit the cognitive decline and neurodegeneration.
|
Report
(4 results)
Research Products
(34 results)
