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Protective effect of hydrogen molecule learning and memory function in oxidative stress induced mice.

Research Project

Project/Area Number 22500680
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNippon Medical School

Principal Investigator

NISHIMAKI Kiyomi  日本医科大学, 老人病研究所, マネージメントサポートスタッフ (00465345)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords老化・加齢 / 酸化ストレス / 水素 / アルツハイマー病 / 加齢、老化
Research Abstract

Accumulation of oxidative stress associated with aging is one of causative factors in the pathogenesis of major neurodegenerative diseases including Alzheimer’ and Parkinson diseases (AD and PD). Hydrogen molecules(H2) are superior antioxidants, selectively reduced the hydroxyl radical,the most cytotoxic Ros, without affecting the other oxygen-derived free radicals. In this study, we investigated the effect of an antioxidant, hydrogen molecule (H2), using DAL mice as Alzheimer's disease animal model. We showed that the consumption of molecular hydrogen reduces brainoxidative stress levels and inhibit the cognitive decline and neurodegeneration.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2013 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (27 results) Remarks (4 results)

  • [Journal Article] Taurine Ameliorates Impaired the Mitochondrial Function and Prevents Stroke-like Episodes in Patients with MELAS2012

    • Author(s)
      Rikimaru N, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y
    • Journal Title

      Internal Medicine

      Volume: 51 Issue: 24 Pages: 3351-3357

    • DOI

      10.2169/internalmedicine.51.7529

    • NAID

      130003308162

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS.2012

    • Author(s)
      Rikimaru N,Kiyomi Nishimaki
    • Journal Title

      Internal Medicine.

      Volume: 51 Pages: 3351-3357

    • NAID

      130003308162

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice2011

    • Author(s)
      Kamimura N, Nishimaki K, Ohsawa I, Ohta S
    • Journal Title

      Obesity

      Volume: 19(7) Issue: 7 Pages: 1396-1403

    • DOI

      10.1038/oby.2011.6

    • Related Report
      2012 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Consumption of hydrogen water is effective for the progression of Alzheimer's disease. AD/PD20132013

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] Hydrogen Molecule improves leaning and memory function in mitochondrial oxidative stress-induced Alzheimer model mice. AD/PD20132013

    • Author(s)
      Takashi Yokota
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] APP transgenic mice with oxidative stress. AD/PD20132013

    • Author(s)
      Naomi Kamimura
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of intravenous transplantation of bone marrow mononuclear cell on Alzheimer's disease mouse models.AD/PD20132013

    • Author(s)
      Takuya Kanamaru
    • Organizer
      The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases
    • Place of Presentation
      Florence, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] CONSUMPTION OF HYDROGEN WATER IS EFFECTIVE FOR THE PROGRESSION OF ALZHEIMER'S DISEASE.2013

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      AD/PD2013 (The 11th International Conference On Alzheimer’s & Parkinson’s Diseases)
    • Place of Presentation
      Florence
    • Related Report
      2012 Annual Research Report
  • [Presentation] HYDROGEN MOLECULE IMPROVES LEARNING AND MEMORY FUNCTION IN MITOCHONDRIAL OXIDATIVE STRESS-INDUCED ALZHEIMER MODEL MICE2013

    • Author(s)
      Takashi Yokota,Kiyomi Nishimaki
    • Organizer
      AD/PD2013 (The 11th International Conference On Alzheimer’s & Parkinson’s Diseases)
    • Place of Presentation
      Florence
    • Related Report
      2012 Annual Research Report
  • [Presentation] APP TRANSGENIC MICE WITH OXIDATIVE STRESS.2013

    • Author(s)
      Naomi Kamimura,Kiyomi Nishimaki
    • Organizer
      AD/PD2013 (The 11th International Conference On Alzheimer’s & Parkinson’s Diseases)
    • Place of Presentation
      Florence
    • Related Report
      2012 Annual Research Report
  • [Presentation] EFFECTS OF INTRAVENOUS TRANSPLANTATION OF BONE MARROW MONONUCLEAR CELL ON ALZHEIMER’S DISEASE MOUSE MODELS.2013

    • Author(s)
      Takuya Kanamaru,Kiyomi Nishimaki
    • Organizer
      AD/PD2013 (The 11th International Conference On Alzheimer’s & Parkinson’s Diseases)
    • Place of Presentation
      Florence
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリアアルデヒド脱水素酵素2活性欠損マウス(DAL101マウス)に対する骨髄単核球移植の認知機能改善効果2012

    • Author(s)
      金丸拓也
    • Organizer
      第12回日本ミトコンドリア学会年会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] Optical recording of oxidative stress in live mice2012

    • Author(s)
      Wolf Alexander M
    • Organizer
      第12回日本ミコンドリア学会年会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト変異APP高発現マウスと酸化ストレス亢進マウスとの掛け合わせマウスの解析2012

    • Author(s)
      上村尚美
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] アルツハイマーモデルマウスに対する他家骨髄単核球投与の認知機能改善効果2012

    • Author(s)
      金丸拓也
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Optical recording of oxidative stress in live Mice2012

    • Author(s)
      Wolf Alexander M
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリアアルデヒド脱水素酵素2活性欠損マウス(DAL101マウス)に対する骨髄単核球移植の認知機能改善効果2012

    • Author(s)
      金丸拓也,西槙貴代美
    • Organizer
      第12回日本ミトコンドリア学会年会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report
  • [Presentation] Optical Recording of Oxidative Stress in Live Mice2012

    • Author(s)
      Wolf Alexander M,Kiyomi Nishimaki
    • Organizer
      第12回日本ミトコンドリア学会年会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report
  • [Presentation] Optical Recording of Oxidative Stress in Live Mice2012

    • Author(s)
      Wolf Alexander M,Kiyomi Nishimaki
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transgenic mice expressing roGFP have potential to estimate oxidative stress in vivo2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transgenic mice expressing the redox-sensitive green fluorescent protein2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      日本ミトコンドリア学会第11回年会5th SFRR-ASIA 8th ASMRM 11th J-mit
    • Place of Presentation
      Kagoshima
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Preventive effect of hydrogen-dissolved water on age-dependent decline of learning and memory in Alzheimer model mice2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      The eighth European Meeting on Mitochondrial Pathology
    • Place of Presentation
      Zaragoza、Spain
    • Year and Date
      2011-06-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transgenic mice expressing roGFP have potential to estimate oxidative stress in vivo2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] IN vivo measurements of skin oxidative stress using mice expressing redox-sensitive GFP2011

    • Author(s)
      Alexander Wolf
    • Organizer
      5th SFRR-Asia, 8th ASMRM, 11th J-mit,2011Symposium
    • Place of Presentation
      Kagoshima
    • Related Report
      2012 Final Research Report
  • [Presentation] Transgenic mice expressing the redox-sensitive green fluorescent protein2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      5th SFRR-Asia, 8th ASMRM, 11th J-mit, 2011 Symposium
    • Place of Presentation
      Kagoshima
    • Related Report
      2012 Final Research Report
  • [Presentation] Preventive effect of hydrogen-dissolved water on age-dependent decline of learning and memory in Alzheimer model mice2011

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      The eighth European Meeting on Mitochondrial Pathology (Euromit 8)
    • Place of Presentation
      スペイン
    • Related Report
      2012 Final Research Report
  • [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memory tasks in Alzheimer model mice2010

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      7th ASMRM (Asian symposium of Mitochondrial Research and Medicine) and 10th J-mit (Japanese Mitochondrial Research and Medicine)
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水素水投与によるアルツハイマー病モデルマウスの神経細胞死抑制と認知障害抑制2010

    • Author(s)
      西槙貴代美
    • Organizer
      日本Cell Death学会(第19回)
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memory tasks in AD model mice2010

    • Author(s)
      Ikuroh Ohsawa
    • Organizer
      International Conference on Alzheimer's Disease (ICAD)
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-06-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memory tasks in Alzheimer model mice2010

    • Author(s)
      Kiyomi Nishimaki
    • Organizer
      7th ASMRM (Asian symposium of Mitochondrial Research andMedicine) and 10th J-mit (Japanese Mitochondrial Research and Medicine)
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://home.nms.ac.jp/ig/saiboseibutsu/gyoseki.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 日本医科大学大学院医学研究科 加齢科学系専攻 細胞生物学分野:最近の研究発表

    • URL

      http://www.nms.ac.jp/ig/biocell/happyou/happyou1.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://home.nms.ac.jp/ig/saiboseibutsu/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://home.nms.ac.jp/ig/saiboseibutsu/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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