| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Accumulation of oxidative stress associated with aging is one of causative factors in the pathogenesis of major neurodegenerative diseases including Alzheimer’ and Parkinson diseases (AD and PD). Hydrogen molecules(H2) are superior antioxidants, selectively reduced the hydroxyl radical,the most cytotoxic Ros, without affecting the other oxygen-derived free radicals. In this study, we investigated the effect of an antioxidant, hydrogen molecule (H2), using DAL mice as Alzheimer's disease animal model. We showed that the consumption of molecular hydrogen reduces brainoxidative stress levels and inhibit the cognitive decline and neurodegeneration.
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