Biological relevance of Coenzyme Q10 binding protein.-Study with prosaposin knockout animal and cell lines-
| Project/Area Number |
22500681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo University of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASHIBA Misato 東京工科大学, 医療保健学部, 講師 (80338186)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMURA Shinichi 東海大学, 医学部, 講師 (30230808)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | コエンザイム Q10 / プロサポシン / サポシン / 脂質 / 脂質結合タンパク質 / ノッ クアウトマウス / コエンザイムＱ１０ / 脂質結合たんぱく質 / ノックアウトマウス / 老化 / 抗酸化物質 / 蛋白質 |
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| Research Abstract |
Coenzyme Q10 (CoQ10) is necessary for ATP biosynthesis. It also is an antioxidant. Saposin B (SapB) is a CoQ10 binding protein.Analysis using prosaposin (Psap, precursor of SapB) knockout mouse revealed that concentrations of exogenous CoQ10 in plasma and liver were significantly reduced in homo-type animal. Psap transfectant (Tf) and knockdown (KD) HepG2 cells are established. CoQ10 contents decreased as follows: Tf > parent > KD. These data imply that SapB and/orits precursor Psap is a modulator for CoQ10 contents.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Increased Oxidative Stress and Coenzyme Q10 Deficiency in Juvenile Fibromyalgia: Amelioration of Hypercholesterolemia and Fatigue by Ubiquinol-102013
Author(s)
Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y, Yokota S, Yamamoto Y
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Journal Title
Supplementation Redox Report
Volume: 18
Issue: 1
Pages: 12-19
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of coenzyme Q10 on salivary secretion 669-674 (2011)2011
Author(s)
Ryo K, Ito A, Takatori R, Tai Y, Arikawa K, Seido T, Yamada T, Shinpo K, Tamaki Y, Fujii K, Yamamoto Y, Saito I
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Journal Title
Clin Biochem
Volume: 44
Issue: 8-9
Pages: 669-674
DOI
Related Report
Peer Reviewed
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[Presentation] プロサポシン遺伝子の改変で細胞内CoQ10の量とその酸化還元状態が変わる2011
Author(s)
加柴美里,大泉美希子,鈴木優,澤村佳美,寺嶋政之,長嶋康平,及川慎吾,ジョン・チュンユン,森内寛,吉村眞一,山本順寛
Organizer
日本酸化ストレス学会関東支部会
Place of Presentation
東京都
Year and Date
2011-12-10
Related Report
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[Presentation] Yamamoto YReduction of oxidative stress in successfully treated patients with community acquired pneumonia (CAP), as measured by redox status of coenzyme Q10 (%CoQ-10)2011
Author(s)
Honda K, Wada H, Tamura M, Takata S, Nakamura M, Yasutake T, Kurai D, Ishii H, Goto H, Fujii K
Organizer
European Respiratory SocietyMeeting
Place of Presentation
Amsterdam, Nederland
Year and Date
2011-09-30
Related Report
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