| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
Protein levels of HIF-1αand angiogenic growth factors were attenuated by glucose in hypoxic mouse mesenchymal stem cells in a dose-dependent manner. We also found that stimulation with a high-glucose concentration significantly increased intracellular superoxide levels and proteasome activity in hypoxic stem cells, which may cause HIF-1α degradation. Thus, the modulation of proteasome activity may ameliorate the impaired therapeutic efficacy by autologous bone-marrow-derived cells in diabetic patients.
|
