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Effect of soy isoflavones on allergic diseases in cross-sectional study

Research Project

Project/Area Number 22500760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

SAKAI Tohru  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40274196)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords大豆 / アレルギー / イソフラボン / 横断研究
Research Abstract

We conducted a cross-sectional study on 1,076 men and 384 women (aged 20-63 years), who were living in Tokushima prefecture, Japan. We obtained information on life style and self-reported history of allergic diseases using a questionnaire. Consumption of vegetable and fish in a group that take high-dose isoflavone were higher than that in a group that take low-dose isoflavones. In contrast, consumption of meat and snack in a group that take high-dose isoflavonse were lower than that in a group that take low-dose isoflavones. Multiple logistic regression models were used to analyze the association between dietary patterns and each allergic diseases. Intake of isoflavones tended to decrease the risk of allergic diseases.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (8 results) Book (1 results)

  • [Journal Article] Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet.2013

    • Author(s)
      Sakai T et al.
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: in press

    • NAID

      130003368160

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane.2013

    • Author(s)
      Jambaldoei B. et al.
    • Journal Title

      J Med Investi

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assocoation between blood levels of PCDs/PCDFs/dioxin-like PCBs and history of allergic and other disease in the Japan population.2013

    • Author(s)
      Nakamoto M et al.
    • Journal Title

      International Archives of Occupational and Environmental Health

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of MHC class II and cathepsin E in NC/Nga mouse dendritic cells2012

    • Author(s)
      Sakai T., Shuto E., Imamura H., Kioka M., Nakamoto A., Mizoguchi S., Amano S., Kawano Y., Nakamoto M., Tsutumi R.Hosaka T
    • Journal Title

      J. Med. Invest

      Volume: 59 Pages: 95-101

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22449997

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of MHC class II and cathepsin E in NC/Nga mouse dendritic ce2012

    • Author(s)
      Sakai, et al
    • Journal Title

      Journal of Medical Investigation

      Volume: 59 Pages: 95-101

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking.2011

    • Author(s)
      Hirata Y, et al
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 405(1) Issue: 1 Pages: 96-101

    • DOI

      10.1016/j.bbrc.2010.12.134

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of dietary lipids on longevity and memory in the SAMP8 mice2011

    • Author(s)
      Ueda Y., Wahg M.-F., Irei A.V., Sarukura N., Sakai T.,and Hsu T.-F
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 57 Pages: 36-41

    • NAID

      10028106052

    • URL

      https://www.jstage.jst.go.jp/article/jnsv/57/1/57_1_36/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice2011

    • Author(s)
      Shiota A, Taketani Y, Maekawa Y, Yasutomo K, Sata M, Sakai T, Mizuno R, Isshiki M, Yamamoto H, Takeda E
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Issue: 2 Pages: 109-114

    • DOI

      10.3164/jcbn.10-150

    • NAID

      130004466642

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracts of common buckwheat bran prevent sucrose digestion2011

    • Author(s)
      Hosaka T., Nii Y., Tomotake H., Ito T., Tamanaha A., Yamasaka Y., Sasaga S., Edazawa K., Tsutsumi R., Shuto E., Okahisa N., Iwata S., and Sakai T.
    • Journal Title

      J. Nutr. Sci. Vitaminol

      Volume: 57 Pages: 441-445

    • NAID

      130002103056

    • URL

      https://www.jstage.jst.go.jp/article/jnsv/57/6/57_6_441/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary nucleic acid induces type 2 T-helper immune responsethrough toll-like receptor 9 in mice2011

    • Author(s)
      Nakamoto M., Shuto E., Hosaka T., and Sakai T.
    • Journal Title

      Eur. J. Nutr

      Volume: 50 Issue: 6 Pages: 421-426

    • DOI

      10.1007/s00394-010-0153-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine2011

    • Author(s)
      Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito T, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S
    • Journal Title

      Blood

      Volume: 117 Issue: 1 Pages: 128-134

    • DOI

      10.1182/blood-2010-07-289611

    • NAID

      120007137632

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice2011

    • Author(s)
      Sakai T., Furoku S., Nakamoto M., Shuto E., and Hosaka T.
    • Journal Title

      Biotech. Biosci. Biochem.

      Volume: 75 Pages: 593-595

    • NAID

      10028202155

    • URL

      https://www.jstage.jst.go.jp/article/bbb/75/3/75_100710/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Breakdown of oral tolerance by Lactococcus lactisin mice2011

    • Author(s)
      Sakai T., Hirota Y., Nakamoto M., Shuto E., Hosaka T., Makino S., and Ikagami S.
    • Journal Title

      iotech. Biosci. Biochem.

      Volume: 75 Pages: 599-601

    • URL

      https://www.jstage.jst.go.jp/article/bbb/75/3/75_100714/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice2011

    • Author(s)
      Sakai, et al
    • Journal Title

      Biotechnology Bioscience and Biochemistry

      Volume: 75 Pages: 593-595

    • NAID

      10028202155

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Breakdown of oral tolerance by Lactococcus lactis in mice2011

    • Author(s)
      Sakai, et al
    • Journal Title

      Biotechnology Bioscience and Biochemistry

      Volume: 75 Pages: 599-601

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice.2011

    • Author(s)
      Sakai, et al
    • Journal Title

      Biotechnology Bioscience and Biochemistry

      Volume: (印刷中)

    • NAID

      10028202155

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Breakdown of oral tolerance by Laotococcus lactis in mice.2011

    • Author(s)
      Sakai, et al
    • Journal Title

      Biotechnology Bioscience and Biochemistry

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice.2010

    • Author(s)
      Sakai T.,Furoku S., Nakamoto M., Shuto E., Hosaka T., Nishioka Y. and Sone S
    • Journal Title

      J. Nutr. Sci. Vitaminol

      Volume: 56 Pages: 72-76

    • NAID

      10025973044

    • URL

      https://www.jstage.jst.go.jp/article/jnsv/56/1/56_1_72/_article

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-l1 adipocytes2010

    • Author(s)
      Chung Ie., Hosaka T., Harada N., Jambaldori B., Fukunaga K., Nishiwaki Y., Teshigawara K., Sakai T.,Nakaya Y., and Funaki M
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 391 Issue: 1 Pages: 995-999

    • DOI

      10.1016/j.bbrc.2009.12.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食物摂取および生活習慣とアレルギー疾患との関連について2010

    • Author(s)
      中本真理子、酒井徹、首藤恵泉、保坂利男、片岡菜奈子、小杉知里、秦明子、篠田香織、桑村由美、南川貴子、市原多香子、田村綾子、船木真理
    • Journal Title

      J. Rehabil. Health Sci

      Volume: 8 Pages: 15-21

    • NAID

      120002855439

    • URL

      http://repository.osakafu-u.ac.jp/dspace/kiyo/jrhs/Vol.8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice.2010

    • Author(s)
      Sakai, et al
    • Journal Title

      Journal of Nutrtional Science and Vitaminology

      Volume: 56 Pages: 72-76

    • NAID

      10025973044

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 核酸は免疫調節機能により糖脂質代謝を制御するのか2012

    • Author(s)
      酒井徹
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      ヤクルトホール(東京都)
    • Year and Date
      2012-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 核酸は免疫調節機能により糖脂質代謝を制御するのか?2012

    • Author(s)
      酒井徹
    • Organizer
      食品免疫学会
    • Place of Presentation
      ヤクルトホール(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳酸菌は糖脂質代謝を制御するの2011

    • Author(s)
      酒井徹、牧野聖也、池上秀二
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-10-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳酸菌は糖脂質代謝を制御できるか?2011

    • Author(s)
      酒井徹
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食餌性核酸による糖および脂質代謝調節作用2011

    • Author(s)
      酒井徹、首藤恵泉
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      広島国際会議場(広島県)
    • Year and Date
      2011-09-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 核酸およびリボ核酸はインスリン抵抗性および脂質代謝を改善する2011

    • Author(s)
      酒井徹、荒川真衣、田崎志保、首藤恵泉、中本真理子、保坂利男
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      お茶の水女子大学(東京都)
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 大豆イソフラボンの免疫制御機構-抗原特異的免疫誘導および炎症性大腸炎に対する作用2010

    • Author(s)
      酒井徹
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 大豆イソフラボンの大腸炎病態制御機構に関する研究2010

    • Author(s)
      酒井徹
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      徳島(アスティ徳島)
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Book] 講談社ライフティフィック2013

    • Author(s)
      酒井徹
    • Total Pages
      24
    • Publisher
      公衆栄養学 第4版
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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