| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
The intracellular level of reduced glutathione (GSH) in immune cells has influences on the immunity. In the present study, we focused on the effect of carotenoids such as ・-carotene on the properties of glutamate-cysteine-ligase (GCL) which is involved in GSH synthesis. Experiments with a GCL specific inhibitor, a translation inhibitor, and a transcription inhibitor revealed that certain caroteonids including ・-carotene induce de novosynthesis of GCL accompanied with the up-regulation of transcription, which resulted in the enhancement of the intracellular GSH level.
|
