An investigation on senescence regulation by trace elements: A trial of zinc nutriomics

• Project/Area Number: 22500772
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Seitoku University
• Principal Investigator: YOKOI Katsuhiko 聖徳大学, 人間栄養学部, 教授 (10200883)
• Co-Investigator(Kenkyū-buntansha): KONOMI Aki 帝京平成大学, 健康メディカル学部, 講師 (40529658)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 食と栄養 / 老化 / 微量元素 / 亜鉛 / プロテオミクス / ニュートリオミクス / 亜船

Research Abstract

Since the Japanese society has already faced advanced population ageing, we investigated a possibility of senescence regulation by trace elements, especially zinc. Zinc-deficient rats revealed alopecia and a decreased body weight gain and retroperitoneal

Research Products

• [Journal Article] 摂取不足が問題になる必須微量元素-特に、亜鉛と鉄を中心に- (2013)
  • Author(s): 横井克彦
  • Journal Title: Foods & Food Ingredients J. Jpn Volume: 218(1):5-11
  • Peer Reviewed
• [Journal Article] 摂取不足が問題になる必須微量元素－特に、亜鉛と鉄を中心に (2013)
  • Author(s): 横井克彦
  • Journal Title: Foods & Food Ingredients J. Jpn. Volume: 218 Pages: 5-11
  • Peer Reviewed
• [Journal Article] 成年女子の"貧血のない鉄欠乏症"における亜鉛値の一考察 (2011)
  • Author(s): 澤田孝子, 許斐亜紀, 横井克彦
  • Journal Title: 微量栄養素研究Trace Nutrients Research Volume: 28:84-88
  • NAID: 40020191832
  • Peer Reviewed
• [Journal Article] 連載・微量元素をめぐる動向(7)鉄:鉄の栄養特性と毒性 (2011)
  • Author(s): 横井克彦
  • Journal Title: ならびに利用と規制 食品衛生研究 Volume: 61(4):23-33
  • Peer Reviewed
• [Journal Article] Comparison of a modified hemoglobin regeneration efficiency method with a slope-ratio assay in measuring relative bioavailability of cocoa powder iron using rats (2011)
  • Author(s): Yokoi K., Konomi A., Otagi M
  • Journal Title: Biol Trace Elem Res Volume: 143(2):1103-1109 Issue: 2 Pages: 1103-1109
  • DOI: 10.1007/s12011-010-8953-1
  • Peer Reviewed
• [Journal Article] 連載・微量元素をめぐる動向(7)鉄:鉄の栄養特性と毒性、ならびに利用と規制 (2011)
  • Author(s): 横井克彦
  • Journal Title: 食品衛生研究 Volume: 61(依頼総説) Pages: 23-33
  • Peer Reviewed
• [Journal Article] Comparison of a Modified Hemoglobin Regeneration Efficiency Method with a Slope-Ratio Assay in Measuring Relative Bioavailability of Cocoa Powder Iron Using Rats (2011)
  • Author(s): Katsuhiko Yokoi, Aki Konomi, Miki Otagi
  • Journal Title: Biol Trace Elem Res(doi 10.1007/s12011-010-8953-1(2011)).
  • Peer Reviewed
• [Journal Article] A possible role of plasma aldosterone in hypotension secondary to iron deficiency anaemia combined with zinc deficiency in rats (2011)
  • Author(s): Aki Konomi, Katsuhiko Yokoi
  • Journal Title: Br J Nutr Volume: 105 Pages: 535-538
  • Peer Reviewed
• [Journal Article] 微量栄養素の摂取基準運用に関する留意点-法と科学に基づく業務の遂行- (2010)
  • Author(s): 横井克彦
  • Journal Title: 日本栄養士会雑誌 Volume: 53(10):4-15
  • Peer Reviewed
• [Journal Article] Effect of zinc supplementation on mood states in young women : a pilot study (2010)
  • Author(s): T.Sawada, K.Yokoi
  • Journal Title: Eur J Clin Nutr Volume: 64 Pages: 331-333
  • Peer Reviewed
• [Presentation] 数学的方法による鉄の必要量の推定と食事摂取基準との比較パネルディスカッション 1「栄養学的見地から見た微量元素の功罪」 (2012)
  • Author(s): 横井克彦
  • Organizer: 第23回日本微量元素学会大会
  • Place of Presentation: 東京都 砂防会館シェーンバッハ・サボー
  • Year and Date: 2012-07-05
• [Presentation] Zinc deficiency and liver protein expression in rats (2011)
  • Author(s): Katsuhiko Yokoi, Aki Konomi
  • Organizer: Minisymposium 2 : Zinc and Selenium International Society for Trace Element Research In Humans (ISTERH), Nineth International Conference
  • Place of Presentation: Rixos Premium Hotel, Belek, Turkey
  • Year and Date: 2011-10-17
• [Presentation] 亜鉛欠乏および摂取制限が肝臓中タンパク質の発現に及ぼす影響 (2011)
  • Author(s): 横井 克彦、許斐 亜紀
  • Organizer: 第22回日本微量元素学会大会
  • Place of Presentation: 京都市 京都テルサ/京都府民総合交流プラザ
  • Year and Date: 2011-07-01
• [Presentation] 亜鉛欠乏および摂取制限が肝臓中タンパク質の発現に及ぼす影響 (2011)
  • Author(s): 横井克彦, 許斐亜紀
  • Organizer: 第22回日本微量元素学会大会
  • Place of Presentation: 京都市京都テルサ/京都府民総合交流プラザ
  • Year and Date: 2011-07-01
• [Presentation] 成年女子の"貧血のない鉄欠乏症"における亜鉛値の一考察 (2011)
  • Author(s): 澤田孝子、許斐亜紀、横井克彦
  • Organizer: 第28回日本微量栄養素学会学術集会
  • Place of Presentation: 京都市 京都リサーチパーク
  • Year and Date: 2011-06-11
• [Presentation] Effect of zinc deficiency on hepatic protein expression patterns in rats (2011)
  • Author(s): Yokoi K, Konomi A
  • Organizer: Minisymposium: Zinc presented at the Experimental Biology 2011
  • Place of Presentation: Washington Convention Center, Washington, DC, USA
  • Year and Date: 2011-04-11
• [Presentation] Effect of zinc deficiency on hepatic protein expression patterns in rats (2011)
  • Author(s): Katsuhiko Yokoi, Aki Konomi
  • Organizer: Minisymposium : Zinc Experimental Biology 2011
  • Place of Presentation: Washington Convention Center, Washington, DC, USA
  • Year and Date: 2011-04-11
• [Presentation] Zinc deficiency and liver protein expression in rats. Minisymposium 2: Zinc and Selenium (2010)
  • Author(s): Katsuhiko Yokoi, Aki Konomi
  • Organizer: International Society For Trace Element Research In Humans (ISTERH), Nineth International Conference
  • Place of Presentation: Rixos Premium Hotel, Belek, Turkey
  • Year and Date: 2010-10-21
• [Presentation] 鉄欠乏とマンガン過剰が脂質代謝に及ぼす影響 (2010)
  • Author(s): 横井克彦、許斐亜紀, 他2名
  • Organizer: 第57回 日本栄養改善学会
  • Place of Presentation: 坂戸市 女子栄養大学
  • Year and Date: 2010-09-12
• [Presentation] 食品中鉄の生物学的利用効率に関するバイオアッセイ (2010)
  • Author(s): 横井克彦、許斐亜紀、小田木美喜
  • Organizer: 第21回日本微量元素学会大会
  • Place of Presentation: 京都市 京都大学百周年時計台記念館
  • Year and Date: 2010-07-03
• [Presentation] 過剰量のルビジウムがラットの血漿生化学パラメーターに及ぼす影響 (2010)
  • Author(s): 内田由佳、許斐亜紀、横井克彦
  • Organizer: 第21回日本微量元素学会大会
  • Place of Presentation: 京都市 京都大学百周年時計台記念館
  • Year and Date: 2010-07-03
• [Presentation] 重度鉄欠乏ラットにみられた血液生化学検査値の異常 (2010)
  • Author(s): 横井克彦、許斐亜紀
  • Organizer: 第27回日本微量栄養素学会学術集会
  • Place of Presentation: 京都市 京都リサーチパーク
  • Year and Date: 2010-06-05
• [Presentation] ラットにおける飼料中ルビジウムと組織中ルビジウムの用量効果関係の検討 (2010)
  • Author(s): 内田由佳、許斐亜紀、横井克彦
  • Organizer: 第27回日本微量栄養素学会学術集会
  • Place of Presentation: 京都市 京都リサーチパーク
  • Year and Date: 2010-06-05
• [Presentation] Hemoglobin regeneration efficiency method revisited : an alternative bioassay for iron bioavailability (2010)
  • Author(s): Katsuhiko Yokoi, Aki Konomi, Miki Otagi
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim Convention Center, Anaheim, CA
  • Year and Date: 2010-05-22
• [Presentation] 鉄欠乏ラットにみられた血液生化学検査値の異常 (2010)
  • Author(s): 横井克彦、許斐亜紀
  • Organizer: 第64回 日本栄養・食糧学会大会
  • Place of Presentation: 徳島 アスティ徳島
  • Year and Date: 2010-05-22
• [Presentation] Effect of iron deficiency on serum lipids in rats
  • Author(s): Katsuhiko Yokoi, Aki Konomi
  • Organizer: Poster presented at the Experimental Biology 2012
  • Place of Presentation: San Diego Convention Centre, San Diego, CA, USA
• [Presentation] 小麦胚芽中亜鉛の生体利用性
  • Author(s): 横井克彦、古川由梨、高橋美貴、吉村有希子
  • Organizer: 第29回日本微量栄養素学会学術集会
  • Place of Presentation: 京都市 京都リサーチパーク
• [Presentation] 数学的方法による鉄の必要量の推定と食事摂取基準との比較
  • Author(s): 横井克彦
  • Organizer: 第23回日本微量元素学会大会パネルディスカッション1「栄養学的見地から見た微量元素の功罪」
  • Place of Presentation: 東京都 砂防会館シェーンバッハ・サボー
• [Presentation] Plasma and liver lipids of iron-deficient rats with excessive dietary manganese
  • Author(s): Katsuhiko Yokoi, Aki Konomi, Itsuki Tachibana, Yuka Uchida
  • Organizer: Minisymposium: Iron, Copper and Chronic Disease presented at the Experimental Biology 2013
  • Place of Presentation: Boston Convention & Exhibition Center, Boston, MA, USA
• [Book] 鉄と亜鉛と銅, ビタミン・ミネラルの科学 (2011)
  • Author(s): 横井克彦, 五十嵐脩、江指隆年
  • Publisher: 東京:朝倉書店
• [Book] 鉄と亜鉛と銅(五十嵐脩、江指隆年監修:ビタミン・ミネラルの科学) (2011)
  • Author(s): 横井克彦
  • Publisher: 朝倉書店