Exploration of antithrombotic substances and development of new functional foodstuffs considering the circadian rhythms of blood coagulation
| Project/Area Number |
22500774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Teikyo University |
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Principal Investigator |
OHKURA Naoki 帝京大学, 薬学部, 准教授 (60349256)
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| Co-Investigator(Kenkyū-buntansha) |
OISHI Katsutaka 独立行政法人産業技術総合研究所, 生物機能工学研究部門, 研究グループ長 (50338688)
TANIGUCHI Masahiko 大阪薬科大学, 薬学部, 准教授 (00278590)
ATSUMI Gen-ichi 帝京大学, 薬学部, 教授 (70276608)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 血栓症 / 機能性食品 / 血液凝固 / 日内変動 / 血栓 / 血管内皮細胞 / PAI-1 / HUVEC |
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| Research Abstract |
The notion that Angelica keiskei (ashitaba) and propolis have anti-thrombotic properties has not yet been scientifically proven. Here, we show that Ashitaba and propolis have potential as antithrombotic foodstuffs. We also showed that xanthoangerol from ashitaba and chrysin from propolis have antithrombotic properties. However, further investigation is needed to develop new functional foodstuffs involving ashitaba and propolis considering the circadian rhythms of blood coagulation.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen activator inhibitor 1 (PAI-1) production2011
Author(s)
Ohkura N, Nakakuki Y, Taniguchi M, Kanai S, Nakayama A, Ohnishi K, Sakata T, Nohira T, Matsuda J, Baba K, Atsumi G
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Journal Title
Biofactors
Volume: 37(6)
Issue: 6
Pages: 455-461
DOI
Related Report
Peer Reviewed
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[Presentation] プロポリスによるプラスミノーゲンアクチベーターインヒビター1(PAI-1)産生の抑制2010
Author(s)
大藏直樹, 安藤久美子, 高田裕子, 西井綾香, 横内晴菜, 福迫莉衣, 渡辺恵美子, 金井志帆, 野平知良, 松田重三, 厚味厳一
Organizer
第15回日本フードファクター学会
Place of Presentation
仙台 (仙台市民会館)
Year and Date
2010-10-05
Related Report
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[Presentation] プロポリスのプラスミノーゲンアクチベーターインヒビター1(PAI-1)産生抑制作用2010
Author(s)
大藏直樹, 安藤久美子, 高田裕子, 西井綾香, 横内晴菜, 福迫莉衣, 渡辺恵美子,金井志帆, 野平知良, 松田重三, 厚味厳一
Organizer
第54回日本薬学会関東支部大会
Place of Presentation
東京 (東京薬科大学)
Year and Date
2010-10-02
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[Presentation] (震災のため誌上開催)ブラジル産プロポリス中のフラボノイドが持つ抗血栓作用
Author(s)
安藤久美子,大藏直樹,高田裕子,西井綾香,横内晴菜,福迫莉衣,渡辺恵美子,金井志帆,野平知良,松田重三, 厚味厳一
Organizer
日本薬学会第131 年会
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