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A study on Anti-H. pylori actions of pomegranate juice

Research Project

Project/Area Number 22500775
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionTokai University

Principal Investigator

MATSUSHIMA Masashi  東海大学, 医学部, 教授 (60280947)

Co-Investigator(Kenkyū-buntansha) SUZUKI Takayoshi  東海大学, 医学部, 准教授 (40287066)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsヘリコバクター・ピロリ / 機能性食品 / 増殖抑制 / IL-8 / ピロリ菌 / ザクロ / 乳酸菌
Research Abstract

Pomegranate juice suppressed growth of all the clinically separated strains of H. pylori and interleukin-8 secretion from stomach cells stimulated by the strains in vitro. As for the germless mice model infected with H. pylori, there were no obvious effects of pomegranate on the bacterial number in the stomach and anti-H. pylori titers in the serum, however, it might strengthen the growth inhibiting action of lactobachilus on H. pylori in the mice model.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (7 results)

  • [Journal Article] Cranberry extract suppresses interleukin-8 secretion fromstomach cells stimulated by Helicobacter pylori in every clinically separated strain but inhibits growth in part of the strains2013

    • Author(s)
      M Matsushima, T Suzuki, A Masui, T Mine, A Takagi
    • Journal Title

      J Funct Foods

      Volume: 5 Pages: 729-735

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cranberry extract suppresses interleukin-8 secretion from stomach cells stimulated by Helicobacter pylori in every clinically separated strain but inhibits growth in part of the strains2013

    • Author(s)
      Masashi Matsushima
    • Journal Title

      Journal of Functional Foods

      Volume: 5 Issue: 2 Pages: 729-735

    • DOI

      10.1016/j.jff.2013.01.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is it effective? to How to use it?: the era has changed in probiotics and functional food products against Helicobacter pylori infection2012

    • Author(s)
      Matsushima M, Takagi A
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27(5) Pages: 851-853

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Double-balloon endoscopy versus magnet-imaging enhanced colonosocpy for difficult colonoscopies, a randomized study2012

    • Author(s)
      Suzuki T, Matsushima M, Fujisawa M, Uchida T, Igarashi M, Koike J, Takagi A, Mi ne T
    • Journal Title

      Endoscopy

      Volume: 44 Pages: 38-42

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy2012

    • Author(s)
      Deguchi R, Nakaminami H, Rimbara E, Noguchi N, Sasatsu M, Suzuki T, Matsushima M, Koike J, Igarashi M, Ozawa H, Fukuda R, Takagi A
    • Journal Title

      J Gastroeterol Hepatol

      Volume: 27 Pages: 888-892

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emergency upper gastrointestinal endoscopy in the emergency room of Tokai University Hospital2011

    • Author(s)
      Matsushima M, Suzuki T, Nakajima T, Arase Y, Tsukune Y, Fujisawa M, Uchida T,Shirakura K, Igarashi M, Koike J, Mine T, Kanari Y, Aoki H
    • Journal Title

      Tokai J Exp Clin Med

      Volume: 36 Pages: 47-52

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胃潰瘍底が脾動脈に穿破して出血をきたした1 例2011

    • Author(s)
      内田哲史,五十嵐宗喜,築根陽子,藤澤美亜,白倉克也,小川真実,小池潤,鈴木孝良,松嶋成志,峯徹哉
    • Journal Title

      Progress in Digestive Endoscopy

      Volume: 79(2) Pages: 64-65

    • NAID

      130004652757

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 保険適応の3 疾患について~ITP~2011

    • Author(s)
      鈴木孝良,松嶋成志,高木敦司,峯徹哉
    • Journal Title

      Helicobacter Research

      Volume: 113(1) Pages: 8-10

    • Related Report
      2012 Final Research Report
  • [Journal Article] 経過中に腸管嚢腫様気腫を生じた潰瘍性大腸炎の一例2011

    • Author(s)
      澤本佳奈,白井孝之,木嶋麻衣子,東徹,築根陽子,大北一郎,渡邊謙一,小池潤,鈴木孝良,松嶋成志,梶原博,峯徹哉
    • Journal Title

      Gatroenterological Endoscopy.

      Volume: 53(5) Pages: 1445-1450

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastrointestinal: Colonic Intusscusception to the rectum with sigmoid colon cancer as a lead point2011

    • Author(s)
      Matsushima M, Suzuki T, Sawamoto K, Takagi A, Mine T
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 26 Pages: 414-414

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] バルーン補助法の適応と実際2011

    • Author(s)
      鈴木孝良,松嶋成志,中島貴之,藤澤美亜,内田哲史,白倉克也,五十嵐宗喜,小池潤,峯徹哉
    • Journal Title

      消化器内視鏡

      Volume: 23(9) Pages: 1525-1529

    • Related Report
      2012 Final Research Report
  • [Journal Article] 東南部地区におけるH.pylori感染症治療の現状をみる---東海大学医学部付属病院のH.pylori診断と治療の実際--2010

    • Author(s)
      松嶋成志,鈴木孝良,五十嵐宗喜,小池潤,峯徹哉,高木敦司
    • Journal Title

      Helicobacter Research

      Volume: 14(5) Pages: 32-35

    • Related Report
      2012 Final Research Report
  • [Journal Article] ダブルバルーン小腸内視鏡が有用であった狭窄型虚血性小腸炎の1例2010

    • Author(s)
      齋藤哲彦,鈴木孝良,渡邊謙一,松嶋成志,白井孝之,峯徹哉,平林健一
    • Journal Title

      Progress of Digestive Endoscopy

      Volume: 77 Pages: 104-105

    • NAID

      130004652627

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of submucosal hematoma of the esophagus and stomach, possibly caused by fish bone ingestion2010

    • Author(s)
      Koike J, Matsushima M, Teraoka H, Igarashi M, Deguchi R, Suzuki T, Shirai T, Mine T
    • Journal Title

      Tokai J Exp Clin Med

      Volume: 35(1) Pages: 46-56

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] ザクロとL. johnsoniiの抗ピロリ菌作用に関するin vitro及びモデル動物による検討2013

    • Author(s)
      松嶋成志ほか
    • Organizer
      日本ヘリコバクター学会
    • Place of Presentation
      長崎
    • Related Report
      2012 Annual Research Report
  • [Presentation] A case of acute portal vein thrombosis due to chronic relapsing pancreatitis2012

    • Author(s)
      M. Kikuchi, H. Shiozawa, I. Hamada, K. Tsuruya, T. Higashi, J. Aoki, R. Nagashima, J. Koizumi, Y. Arase, K. Shiraishi, Y. Nishizaki, M. Matsushima.
    • Organizer
      Asian Pacific Digestive Week 2012
    • Place of Presentation
      Bangkok
    • Year and Date
      2012-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] A very rare case of malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's Nodule2012

    • Author(s)
      K. Tsuruya, M. Matsushima, T. Nakajima, M. Fujisawa, T. Uchida, K. Shirakura, M. Igarashi, J. Koike, T. Suzuki, I. Hamada, T. Higashi, M. Kikuchi, H. Shiozawa, J. Aoki, Y. Nishizaki, T. Mine
    • Organizer
      Asian Pacific Digestive Week 2012
    • Place of Presentation
      Bangkok
    • Year and Date
      2012-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Is premedication with an anti-cholinergic reagent necessary for transnasal endoscopy?2012

    • Author(s)
      M.Matsushima, T.Suzuki, A.Masui, A.Takagi, T.Mine
    • Organizer
      Asian Pacific Digestive Week 2012
    • Place of Presentation
      Bangkok
    • Year and Date
      2012-12-06
    • Related Report
      2012 Final Research Report
  • [Presentation] クランベリーおよびザクロ果汁の抗ヘリコバクター・ピロリ作用について2011

    • Author(s)
      松嶋成志,鈴木孝良,峯徹哉
    • Organizer
      第53回日本消化器病学会大会ワークショップ
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] クランベリーおよびザクロ果汁の抗ヘリコバクター・ピロリ作用について2011

    • Author(s)
      松嶋成志、鈴木孝良、峯徹哉
    • Organizer
      日本消化器関連学会週間2011ワークショップ18消化器疾患におけるprobioticsと機能性食品の有用性
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] What is the proper screening after H.pylori eradication?2011

    • Author(s)
      Matsushima M, Suzuki T, Koike J, Igarashi M, Mine T, Takagi A
    • Organizer
      A proposal from the study on our case of post-HP-eradicated stomach cancer APDW2011
    • Place of Presentation
      Singapore
    • Year and Date
      2011-10-02
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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