| Project/Area Number |
22500782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
|
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
IKEDA Saiko 名古屋学芸大学, 管理栄養学部, 教授 (80308808)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Tomono 愛知学泉大学, 家政学部, 講師 (50440821)
NOMURA Saki 名古屋学芸大学, 管理栄養学部, 助手 (90588956)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 食と栄養 / ビタミン / 栄養学 / ビタミンE / トコフェロール / トコトリエノール / 代謝 |
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| Research Abstract |
The aim of this study was to evaluate vitamin E catabolism in small intestine and its impact on the tissue distribution of vitamin E metabolites. CEHC was in small intestine of rats after oral administration of vitamin E isoform. We found the catabolic conversion of vitamin E isoform to its metabolite in human intestinal Caco-2 cells. Sesamin, an inhibitor of cytochrome P450-dependent catabolism of vitamin E, increased vitamin E concentration in rat small intestine. Therefore, some dietary vitamin E is likely to be catabolized to CEHC in the small intestine during absorption.
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