Role of vitamin in the prevention of osteoporosis.

• Project/Area Number: 22500784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kyoto Women's University
• Principal Investigator: TANAKA Kiyoshi 京都女子大学, 家政学部・食物栄養学科, 教授 (90227132)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ビタミン D / ビタミン K / 骨粗鬆症 / 骨折 / 高齢者 / ビタミンK / 腸内細菌 / ビタミンD / 大腿骨近位部骨折 / 低栄養 / 費用対効果

Research Abstract

Insufficiency of vitamin D and vitamin K was quite prevalent in patients with hip fracture and institutionalized elderly subjects, which was independent of the general malnutrition. Vitamin K requirement in the bone was much greater than in the liver. Thus, bone was much more susceptible to vitamin K insufficiency. Vitamin K production by the intestinal flora was found to make a significant contribution when the vitamin K intake was insufficient.

Research Products

• [Journal Article] Enteral nutrition and antibiotic use increase the risk for vitamin K deficiency in patients with severe motor and intellectual disabilities. (2013)
  • Author(s): Nagae A, Kuwabara A, Tozawa K, Kumode M, Takeuchi Y, Tanaka K.
  • Journal Title: e-SPEN Journal Volume: 18 Pages: 31-36
• [Journal Article] Dietary Reference Intakes for Japanese2010: Fat-soluble vitamins. (2013)
  • Author(s): Tanaka K, Terao J, Shidoji Y, Tamai H, Imai E, Okano T.
  • Journal Title: J Nutr Sci Vitaminol Volume: 59
• [Journal Article] Dietary Reference Intakes for Japanese 2010: Fat-soluble vitamins. (2013)
  • Author(s): Tanaka K.
  • Journal Title: J Nutr Sci Vitaminol Volume: 59
  • NAID: 130003368186
  • Peer Reviewed
• [Journal Article] Fat restriction isassociated with impaired quality of life (QOL) inpatients with ulcerative colitis and Crohn'sdisease. (2011)
  • Author(s): Kuwabara A, Nakase H, Tsuji H, Shide K,Chiba T, Inagaki N, Tanaka K.
  • Journal Title: Ulcers Vol.
• [Journal Article] Bone is more susceptible to vitamin K deficiency than liver in the institutionalized elderly. (2011)
  • Author(s): Kuwabara A, Fujii M,Kawai N,Tozawa K, Kido S,Tanaka K.
  • Journal Title: Asia Pac J Clin Nutr Volume: 20 Pages: 50-5
• [Journal Article] High prevalence of hypovitaminosis D and K in patients with hip fracture. (2011)
  • Author(s): Nakano T, Tsugawa N, Kuwabara A, Kamao M, Tanaka K, Okano T.
  • Journal Title: Asia Pac J Clin Nutr. Volume: 20 Pages: 56-61
• [Journal Article] Overestimated serum albumin levels in patients with hip fracture. (2011)
  • Author(s): Nakano T, Kuwabara A, Tanaka K
  • Journal Title: Clin Nutr. Volume: 30 Pages: 261-261
• [Journal Article] Relation of homocysteine and homocysteine-related vitamins to bone mineral density in Japanese patients with type 2 diabetes. (2011)
  • Author(s): Yamada C, Fujimoto S, Ikeda k, Nomura Y, Matsubara A, Kanno M, Shide K, Tanaka K, Imai E, Fukuwatari T, Shibata K, Inagaki N.
  • Journal Title: J Diabetes Invest Volume: 2 Pages: 233-239
• [Journal Article] Body weight divided by squared knee height as an alternative to body mass index. (2011)
  • Author(s): Kuwabara A, Ogawa-Shimokawa Y, Tanaka K
  • Journal Title: Med Hypotheses Volume: 76 Pages: 336-8
• [Journal Article] Overestimated serum albumin levels in patients with hip fracture (2011)
  • Author(s): Nakano T, Tanaka K, 他
  • Journal Title: Clinical Nutrition Volume: 30 Pages: 261-261
  • Peer Reviewed
• [Journal Article] 日本人の食事摂取基準における目安量は健康人の摂取の中央値でよいのか? (2011)
  • Author(s): 田中清、桑原晶子, 他
  • Journal Title: ビタミン Volume: 85 Pages: 608-609
  • NAID: 110008762055
  • Peer Reviewed
• [Journal Article] 栄養とビタミンD (2011)
  • Author(s): 桑原晶子、田中清, 他
  • Journal Title: The Bone Volume: 25 Pages: 271-275
• [Journal Article] High prevalence of hypovitaminosis D and K in patients with hip fracture. (2011)
  • Author(s): Nakano T, Tanaka K, 他4名
  • Journal Title: Asia Pacific Journal of Clinical Nutrition Volume: 20 Pages: 56-61
  • Peer Reviewed
• [Journal Article] Bone is more susceptible to vitamin K deficiency than liver in the institutionalized elderly. (2011)
  • Author(s): Kuwabara A, Tanaka K, 他4名
  • Journal Title: Asia Pacific Journal of Clinical Nutrition Volume: 20 Pages: 50-55
  • Peer Reviewed
• [Journal Article] Relation of homocysteine and homocysteine-related vitamins to bone mineral density in Japanese patients with type 2 diabetes. (2011)
  • Author(s): Yamada C, Tanaka K, 他10名
  • Journal Title: Journal of Diabetes Investigation Volume: (In press)
  • Peer Reviewed
• [Journal Article] Body weight divided by squared knee height as an alternative to body mass index. (2011)
  • Author(s): Kuwabara A, Tanaka K, 他1名
  • Journal Title: Medical Hypotheses Volume: 76 Pages: 336-338
  • Peer Reviewed
• [Journal Article] Overestimated serum albumin levels in patients with hip fracture. (2011)
  • Author(s): Nakano T, Tanaka K, 他1名
  • Journal Title: Clinical Nutrition Volume: 30 Pages: 261-261
  • Peer Reviewed
• [Journal Article] Fat restriction is associated with impaired quality of life (QOL) in patients with ulcerative colitis and Crohn's disease. (2011)
  • Author(s): Kuwabara A, Tanaka K, 他5名
  • Journal Title: Ulcers
  • Peer Reviewed
• [Journal Article] Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly. (2010)
  • Author(s): Kuwabara A, Himeno M, Tsugawa N, Kamao M, Fujii M, Kawai N, Fukuda M, Ogawa Y, Kido S, Okano T, Tanaka K.
  • Journal Title: Asia Pac J Clin Nutr. Volume: 19 Pages: 49-56
• [Journal Article] Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly. (2010)
  • Author(s): Kuwabara A, Tanaka K, 他9名
  • Journal Title: Asia Pacific Journal of Clinical Nutrition Volume: 19 Pages: 49-56
  • Peer Reviewed
• [Presentation] Predictive value of historical height loss and current height/knee height ratio for prevalent vertebral fracture. (2012)
  • Author(s): Kuwabara A, Tanaka K, Yoh K.
  • Organizer: American Society for Bone and MineralResearch 34th Annual meeting
  • Place of Presentation: アメリカ、ミネアポリス
• [Presentation] The impact of vitamin K therapy on bone metabolic markers in severe motor and intellectual disabilities (2011)
  • Author(s): Kuwabara A, Tanaka K, 他
  • Organizer: American Society for Bone and Mineral Research 33rd Annual Meeting
  • Place of Presentation: 米国サンディエゴ市
  • Year and Date: 2011-09-18
• [Presentation] Evaluation of Effect of Raloxifene Hydrochloride on the Quality of Life of Patients with Postmenopausal Osteoporosis (2011)
  • Author(s): Yoh K, Tanaka K, 他
  • Organizer: American Society for Bone and Mineral Research 33rd Annual Meeting
  • Place of Presentation: 米国サンディエゴ市
  • Year and Date: 2011-09-17
• [Presentation] Nutritional aspects of osteoporosis (2011)
  • Author(s): Tanaka K
  • Organizer: Asia Pacific Congress on Clinical Nutrition
  • Place of Presentation: タイ バンコク市(招待講演)
  • Year and Date: 2011-06-08
• [Presentation] Vitamin D deficiency, a world-wide epidemic (2011)
  • Author(s): Tanaka K
  • Organizer: Asia Pacific Congress on Clinical Nutrition
  • Place of Presentation: タイ バンコク市(招待講演)
  • Year and Date: 2011-06-08
• [Presentation] Medical nutrition therapy from the socieo-economic perspectives (2011)
  • Author(s): Tanaka K
  • Organizer: Asia Pacific Congress on Clinical Nutrition
  • Place of Presentation: タイ バンコク市(招待講演)
  • Year and Date: 2011-06-08
• [Presentation] The impact of vitamin K therapy on bone metabolic markers in severe motor and intellectual disabilities. (2011)
  • Author(s): Kuwabara A, Nagae A, Tsugawa N, KitagawaM, Tozawa K, Kohno H, Miura M, Okano T, Kumode M, Tanaka K.
  • Organizer: American Society for Bone and Mineral Research 33rdAnnual Meeting
  • Place of Presentation: アメリカ、サンディエゴ
• [Presentation] (2011)
  • Author(s): Tanaka K
  • Organizer: Nutritional aspects of osteoporosis Asia Pacific Congress on Clinical Nutrition
  • Place of Presentation: タイ、バンコク
• [Presentation] (2011)
  • Author(s): Tanaka K
  • Organizer: Vitamin D deficiency, a world-wide epidemic Asia Pacific Congress on Clinical Nutrition
  • Place of Presentation: タイ、バンコ ク
• [Presentation] (2011)
  • Author(s): Tanaka K
  • Organizer: Medical nutrition therapy from the socieo-economic perspectives Asia Pacific Congress on Clinical Nutrition
  • Place of Presentation: タイ、バンコク
• [Presentation] Evaluation of effect of raloxifene hydrochloride on the quality of life of patients with postmenopausal osteoporosis. (2011)
  • Author(s): Yoh K, Hamaya E, Iikuni N, Takagaki N, Yamamoto T, Taketsuna M, Miyauchi A, Sowa H, Urushihara H, Tanaka K.
  • Organizer: American Society for Bone and MineralResearch 33rd Annual Meeting
  • Place of Presentation: アメリカ、サンディエゴ
• [Presentation] Effectiveness of urinary gamma-glutamyltransferase as screening for osteoporosis. (2011)
  • Author(s): Tanaka S, Moriwaki S, Uenishi K, Koinuma N, Tanaka K, Ikeda Y, Niida S.
  • Organizer: American Society for Bone and Mineral Research 33rd Annual Meeting
  • Place of Presentation: アメリカ、サンディエゴ
• [Presentation] Vitamin K deficiency in subjects with severe motor and intellectual disabilities. (2010)
  • Author(s): Kuwabara A, Nagae A, Tsugawa N, Tozawa K, Kitagawa M, Kohno H, Miura M, Okano T, Kumode M, Tanaka K.
  • Organizer: American Society for Bone and Mineral Research 32nd Annual Meeting
  • Place of Presentation: カナダ、トロント
• [Presentation] Vitamin K Deficiency in Subjects with Severe Motor and Intellectual Disabilities. (2010)
  • Author(s): Kuwabara A, Tanaka K, 他8名
  • Organizer: American Society for Bone and Mineral Research, 32nd Annual Meeting
  • Place of Presentation: カナダ、トロント市
• [Presentation] 脂溶性ビタミンの食事摂取基準 (2010)
  • Author(s): 田中清
  • Organizer: 日本栄養改善学会近畿支部 公開講座
  • Place of Presentation: 京都府京都市
• [Presentation] 骨の健康とビタミン -食事摂取基準2015年にむけて- (2010)
  • Author(s): 田中清
  • Organizer: 第57回日本栄養改善学会シンポジウム
  • Place of Presentation: 埼玉県坂戸市
• [Presentation] 社会におけるビタミンの役割 (2010)
  • Author(s): 田中清
  • Organizer: 平成22年度「ビタミンの日」記念講演会
  • Place of Presentation: 滋賀県大津市
• [Presentation] Predictive Value of Historical Height Loss and Current Height/knee Height Ratio for Prevalent Vertebral Fracture.
  • Author(s): Kuwabara A.
  • Organizer: American Society for Bone and Mineral Research, 34th Annual Meeting
  • Place of Presentation: Minneapolis, MN, USA
• [Book] ビタミンKビタミンの新栄養学(柴田克己、福渡努編集) (2012)
  • Author(s): 田中清、桑原晶子
  • Publisher: 講談社サイエンティフィック
• [Book] ロコモティブシンドロームにおいて栄養療法の果たすべき役割ロコモティブシンドロームと栄養2(田中清、上西一弘、近藤和夫編集) (2012)
  • Author(s): 田中清、藤井彩乃、桑原晶子
  • Publisher: 建帛社
• [Book] ロコモティブシンドロームの将来展望ロコモティブシンドロームと栄養(田中清、上西一弘、近藤和夫編集) (2012)
  • Author(s): 田中清
  • Publisher: 建帛社
• [Book] 脂溶性ビタミンポケット食事摂取基準(国立健康・栄養研究所監修) (2012)
  • Author(s): 田中清
  • Publisher: 建帛社
• [Book] ビタミンの新栄養学 （ビタミンKの項を担当） (2012)
  • Author(s): 田中清
  • Total Pages: 253
  • Publisher: 講談社サイエンティフィック
• [Book] 栄養ケアマネジメントファーストトレーニング （骨粗鬆症の栄養ケアマネジメントの項を担当） (2012)
  • Author(s): 田中清
  • Total Pages: 152
  • Publisher: 医歯薬出版
• [Book] 治療の目標と進め方-栄養面での指導の進め方骨粗鬆症のトータルマネジメント(中村耕三・遠藤直人編集) (2010)
  • Author(s): 田中清、桑原晶子
  • Publisher: 中山書店
• [Book] 桑原晶子ビタミンKの臨床ビタミン総合事典(日本ビタミン学会編集) (2010)
  • Author(s): 田中清
  • Publisher: 朝倉書店