| Project/Area Number |
22500790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyushu Women's University |
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Principal Investigator |
HIROTA Sachiok 九州女子大学, 家政学部 栄養学科, 准教授 (00312140)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Makiko 九州女子大学, 家政学部, 准教授 (00268814)
TAKAHAMA Umeo 九州歯科大学, 歯学部, 教授 (30106273)
HIGASHI Sen 九州歯科大学, 歯学部, 助教 (40228705)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | ポリフェノール / 一酸化窒素 / クロッシン / 澱粉消化 / 亜硝酸塩 / 唾液 / 胃腔 / プロアントシアニジン / 澱粉 / おくび |
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| Research Abstract |
This research aims to show that nitric oxide generated in the stomach can participate in improvement of the function of the stomach. Polyphenols contained in food were suggested to be able to promote nitric oxide generation by reducing salivary nitrite in the stomach. This redox reaction also suggested that polyphenols could be able to remove harmful salivary nitrite in the stomach. Moreover, it was suggested that crocin, which is a water-soluble carotenoid, could also reduce nitrous acid to nitric oxide in the stomach, and the reduction by crocin was suppressed significantly by starch. On the other hand, polyphenol formed complexes with starch by binding to the helical structure, and the binding resulted in the suppression of a-amylase-catalyzed digestion of starch. Crocin/starch complexes can be transferred into the intestine because of slow oxidation of crocin bound to starch in the stomach. Crocin enhanced a-amylase-catalyzed digestion of starch in the absence of sodium nitrite, but did not affect the starch digestion in the presence of 100 mM sodium chloride.
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