Involvement of IGF-1 and IGFBPs in nutrition during pregnancy and infancy
| Project/Area Number |
22500791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
UCHIYAMA Fumiaki 中村学園大学, 大学院・栄養科学研究科, 教授 (20389331)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Insulin-like growth factor 1 (IGF-1) / IGF-binding proteins / IGF-1 / IGF binding proteins / DNA microarray / Insukin-like growth factor-1 / IGF結合蛋白質 / 組換え体 / Insulin-like growth factor-1 / pregnancy-associated plasma protein-A / metalloprotease domain / 合成基質 |
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| Research Abstract |
This study investigated the expression profile of IGF-related genes in the liver of female rats with differential food intake with or without Lepidium Meyenii root by using DNA microarray. The expression of IGF-related genes presented in changes within ±50%. Uniquely, there was an 8.5-fold increase in IGFBP-2 mRNA expression. These results show that Lepidium Meyenii root may specifically induce the IGFBP-2 gene expression in rat liver.
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Report
(4 results)
Research Products
(29 results)
