Involvement of IGF-1 and IGFBPs in nutrition during pregnancy and infancy

• Project/Area Number: 22500791
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Nakamura Gakuen College
• Principal Investigator: UCHIYAMA Fumiaki 中村学園大学, 大学院・栄養科学研究科, 教授 (20389331)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Insulin-like growth factor 1 (IGF-1) / IGF-binding proteins / IGF-1 / IGF binding proteins / DNA microarray / Insukin-like growth factor-1 / IGF結合蛋白質 / 組換え体 / Insulin-like growth factor-1 / pregnancy-associated plasma protein-A / metalloprotease domain / 合成基質

Research Abstract

This study investigated the expression profile of IGF-related genes in the liver of female rats with differential food intake with or without Lepidium Meyenii root by using DNA microarray. The expression of IGF-related genes presented in changes within ±50%. Uniquely, there was an 8.5-fold increase in IGFBP-2 mRNA expression. These results show that Lepidium Meyenii root may specifically induce the IGFBP-2 gene expression in rat liver.

Research Products

• [Journal Article] 食品の多成分系生体応答機構 (2012)
  • Author(s): 内山文昭
  • Journal Title: 中村学園大学薬膳科学研究所・研究紀要 Volume: 5号 Pages: 1-4
  • NAID: 120005724210
  • Peer Reviewed
• [Journal Article] 食品の多成分系生体応答機構 (2012)
  • Author(s): 内山 文昭
  • Journal Title: 中村学園大学薬膳科学研究所研究紀要 Volume: 5号 Pages: 1-4
  • NAID: 120005724210
  • Peer Reviewed
• [Journal Article] 消化管における食物成分の認知機構と生理機能の誘導 (2011)
  • Author(s): 内山文昭、治京玉記
  • Journal Title: 中村学園大学薬膳科学研究所・研究紀要 Volume: 4号 Pages: 1-5
  • NAID: 120005724218
  • Peer Reviewed
• [Journal Article] Current Progress of Amniotic Fluid Proteome Analysis (2011)
  • Author(s): Tamaki Jikyo and Fumiaki Uchiyama
  • Journal Title: Proceedings of PAMD Institute of Nakamura Gakuen University Volume: 4 Pages: 6-24
  • NAID: 120005724215
  • Peer Reviewed
• [Journal Article] Challenge inprotein-small molecule Interactions. (2010)
  • Author(s): Uchiyama F
  • Journal Title: Proceedings of PAMD Institute of Nakamura Gakuen University Volume: 3 Pages: 1-6
  • Peer Reviewed
• [Presentation] ペルー産薬用植物マカのラットに対する黄体形成ホルモン(LH)の分泌促進効果の影響 (2013)
  • Author(s): 治京玉記,竹田亮介,緒方みさと,内山文昭
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 神奈川県、パシフィコ横浜
  • Year and Date: 2013-03-28
• [Presentation] マイクロアレイ解析によるマカの生理機能探索 (2013)
  • Author(s): 緒方みさと,治京玉記,竹田亮介,内山文昭
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 神奈川県、パシフィコ横浜
  • Year and Date: 2013-03-28
• [Presentation] Application to protein analysis by thin layer chromatography (2012)
  • Author(s): T. Jikyo, T. Kimura and F. Uchiyama、
  • Organizer: 32 th International Symposium on the Separation of Proteins, Peptides and Polynucleotides
  • Place of Presentation: Istanbu, Turkey
  • Year and Date: 2012-09-24
• [Presentation] Generation of the conformational propensities in phage peptide libraries (2012)
  • Author(s): F. Uchiyama,M. Ogata and T. Jikyo
  • Organizer: 9 th European Symposium on Biochemical Engineering Science ISPPP
  • Place of Presentation: Istanbu, Turkey
  • Year and Date: 2012-09-24
• [Presentation] ファージディスプレイにおけるペプチド融合法と親和性 (2012)
  • Author(s): 竹田亮介,緒方みさと,治京玉記,内山文昭
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] ファージディスプレイによるランダムペプチドの鎖長と立体構造の変化 (2012)
  • Author(s): 緒方みさと、竹田亮介、治京玉記、内山文昭
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] Phage displayにおけるペプチド融合法と親和性 (2012)
  • Author(s): 竹田亮介, 緒方みさと, 治京玉記, 内山文昭
  • Organizer: 日本薬学会第132年回
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-03-30
• [Presentation] ファージディスプレイによるランダムペプチドの鎖長と立体構造の変化 (2012)
  • Author(s): 緒方みさと、竹田亮介、治京玉記、内山文昭
  • Organizer: 日本薬学会第132年回
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-03-30
• [Presentation] TLC法を用いたタンパク質解析への適用 (2012)
  • Author(s): 治京玉記、木村太郎、緒方みさと、内山文昭
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] TLC法を用いたタンパク質解析への適用 (2012)
  • Author(s): 治京玉記, 木村太郎, 緒方みさと、内山文昭
  • Organizer: 日本薬学会第132年回
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-03-29
• [Presentation] 陰イオン交換型シリカゲルの作成と蛋白質分離用HPLCへの応用 (2011)
  • Author(s): 河合真、信原一敬、治京玉記、内山文昭
  • Organizer: 第27回日本イオン交換研究発表会・第30回溶媒抽出討論会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-11-25
• [Presentation] 陰イオン交換型シリカゲルの作成と蛋白質分離用HPLCへの応用 (2011)
  • Author(s): 河合真、信原一敬、治京玉記、内山文昭
  • Organizer: 第27回日本イオン交換研究発表会・第30回溶媒抽出討論会
  • Place of Presentation: シーガイアコンベンションセンター(宮崎市)
  • Year and Date: 2011-11-25
• [Presentation] ファージペプチドライブラリーを用いたストレプトアビジン結合ペプチドの同定 (2011)
  • Author(s): 内山文昭、治京玉記、竹田亮介、金子美帆子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 岡山
  • Year and Date: 2011-03-31
• [Presentation] ファージペプチドライブラリーを用いたストレプトアビジン結合ペプチドの同定 (2011)
  • Author(s): 内山文昭、治京玉記、竹田亮介、金子美帆子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 要旨発表(震災のため学会中止)
  • Year and Date: 2011-03-31
• [Presentation] HPLC法を用いたヒト尿解析への適用 (2011)
  • Author(s): 治京玉記、竹田亮介、金子美帆子、内山文昭
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 要旨発表(震災のため学会中止)
  • Year and Date: 2011-03-29
• [Presentation] Preference of amino acid residues in the synthesis of cyclic peptides (2010)
  • Author(s): T. Jikyo and F. Uchiyama
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii Convention, Center
  • Year and Date: 2010-12-19
• [Presentation] Engineering of M13 minor coat protein generates conformational variability in phagepeptide libraries (2010)
  • Author(s): F. uchiyama、T.Chihara, T. Jikyo, S.Mori and M. Kaneko
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii Convention, Center
  • Year and Date: 2010-12-19
• [Presentation] Engineering of M13 minor coat protein generates conformational variability in phage peptide libraries (2010)
  • Author(s): F.uchiyama, T.Chihara, T.Jikyo, S.Mori, M.Kaneko
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii Convention Center(ハワイ)
  • Year and Date: 2010-12-19
• [Presentation] Preference of amino acid residues in the synthesis of cyclic peptides (2010)
  • Author(s): T.Jikyo, F.Uchiyama
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Hawaii Convention Center(ハワイ)
  • Year and Date: 2010-12-19
• [Presentation] Generation of the conformational propensities in phage peptide libraries
  • Author(s): Fumiaki Uchiyama
  • Organizer: 9 th European Symposium on Biochemical Engineering Science ISPPP
  • Place of Presentation: トルコ、イスタンブール、The Grand Cevahir Hotel and Congress Center
• [Presentation] Application to Protein Analysis by Thin Layer Chromatography
  • Author(s): Tanaki Jikyo
  • Organizer: 32th International Symposium on the Separation of Proteins, Peptides and Polynucleotides
  • Place of Presentation: トルコ、イスタンブール、The Grand Cevahir Hotel and Congress Center
• [Presentation] マイクロアレイ解析によるマカの生理機能探索
  • Author(s): 緒方みさと
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 神奈川県、パシフィコ横浜
• [Presentation] ペルー産薬用植物マカのラットに対する黄体形成ホルモン（LH）の分泌促進効果の影響
  • Author(s): 治京玉記
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 神奈川県、パシフィコ横浜
• [Remarks]
  • URL: http://www.nakamura-u.ac.jp/~yakuzen/bunshi/index.html