| Project/Area Number |
22500795
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
|
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| Research Institution | Shokei University |
|---|
Principal Investigator |
SAKATA Atsuko 尚絅大学, 生活科学部, 教授 (70167849)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIRASHIMA Mituomi 香川大学, 医学部, 教授 (70109700)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | ガレクチン-9 / 免疫調節 / ガレクチン－９ / 機能性食品 |
|---|
| Research Abstract |
Using U937 cells and human PBMC, we searched for the functional ingredient of the foodhaving the regulatory activity of galectin-9 expression which had particularly a varietyof immunoregulatory action in galectin family molecules. In the result, fucoidan, notlychee extract or catechin, had inhibitory activity of galectin-9 expression withstrong inflammatory cytokine induction, suggesting the possibility that fucoidan mightenhance the inflammatory cytokine production by reducing expression of galectin-9 whichhas an immunosuppressive function.
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