Regulation of Wnt activity by SOX17 in gastrointestinal tumorigenesis

• Project/Area Number: 22500996
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Carcinogenesis
• Research Institution: Kanazawa University
• Principal Investigator: OSHIMA Hiroko 金沢大学, がん進展制御研究所, 助教 (80362515)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大腸がん / 胃がん / SOX17 / マウスモデル / Wnt / SPX17 / 悪性化

Research Abstract

Transcription factor SOX17 has shown to function as “tumor promoter” and also “tumor suppressor”, and the role of SOX17 in tumorigenesis has not yet been elucidated. In this project, the role of SOX17 in intestinal tumorigenesis has been examined by genetic studies. Disruption of SOX17 in Apc^Δ716 mouse model resulted in thickened gastric mucosa and significant increase of colonic polyps. These results indicate that SOX17 functions as tumor suppressor in colon cancer development.

Research Products

• [Journal Article] The role of PGE2-associated inflammatory responses in gastric cancer development (2013)
  • Author(s): Oshima H, and Oshima M
  • Journal Title: Semin Immunopathol Volume: 47 Issue: 2 Pages: 139-150
  • DOI: 10.1007/s00281-012-0353-5
  • Peer Reviewed
• [Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells (2012)
  • Author(s): Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa T, and Oshima M.
  • Journal Title: Oncogene Volume: (in press) Issue: 35 Pages: 3949-60
  • DOI: 10.1038/onc.2011.558
  • NAID: 120003779577
  • Peer Reviewed
• [Journal Article] S TAT 3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation (2012)
  • Author(s): Tye H, Kennedy CL, Najdovska M, McLeod L, McCormach W, Hughes N, Dev A, Sievert W, Ooi CH, Ishikawa TO, Oshima H, Bhathal PS, Parker A, Oshima M, Tan P, and Jenkins B
  • Journal Title: Cancer Cell Volume: 22 Issue: 4 Pages: 466-478
  • DOI: 10.1016/j.ccr.2012.08.010
  • Peer Reviewed
• [Journal Article] The inflammatory network in the gastrointestinal tumor microenvironment : Lessons from mouse models (2012)
  • Author(s): Oshima H, and Oshima M.
  • Journal Title: J Gastroenterol Volume: 47 Issue: 2 Pages: 97-106
  • DOI: 10.1007/s00535-011-0523-6
  • NAID: 10030295848
  • Peer Reviewed
• [Journal Article] Activation of epidermal growth factor receptor signaling by the prostaglandin E_2 receptor EP4 pathway during gastric tumorigenesis (2011)
  • Author(s): Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa T, and Oshima M.
  • Journal Title: Cancer Sci Volume: 102 Issue: 4 Pages: 713-719
  • DOI: 10.1111/j.1349-7006.2011.01847.x
  • NAID: 10029291933
  • Peer Reviewed
• [Journal Article] Prostaglandin E_2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors (2011)
  • Author(s): Oshima H, Hioki K, Popivanova BK, Oguma K, van Rooijen N, Ishikawa T, and Oshima M.
  • Journal Title: Gastroenterology Volume: 140 Issue: 2 Pages: 596-607
  • DOI: 10.1053/j.gastro.2010.11.007
  • NAID: 120002829318
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. (2011)
  • Author(s): Oshima H, et al.
  • Journal Title: Gastroenterology Volume: 140 Pages: 596-607
  • NAID: 120002829318
  • Peer Reviewed
• [Journal Article] Activation of epidermal growth factor receptor signaling by the prostaglandin E_2 receptor EP4 pathway during gastric tumorigenesis. (2011)
  • Author(s): Oshima H, et al.
  • Journal Title: Cancer Science Volume: 102 Pages: 713-719
  • NAID: 10029291933
  • Peer Reviewed
• [Journal Article] Mouse models of gastric tumors : Wnt activation and PGE_2 induction (2010)
  • Author(s): Oshima H and Oshima M.
  • Journal Title: Pathol Int Volume: 60 Issue: 9 Pages: 599-607
  • DOI: 10.1111/j.1440-1827.2010.02567.x
  • NAID: 10031123383
  • Peer Reviewed
• [Journal Article] Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development (2010)
  • Author(s): Oguma K, Oshima H, and Oshima M
  • Journal Title: Future Oncology Volume: 6 Issue: 4 Pages: 515-526
  • DOI: 10.2217/fon.10.13
• [Journal Article] Gastric tumor mouse models : Wnt activation and PGE_2 induction. (2010)
  • Author(s): Oshima H, et al.
  • Journal Title: Pathology lnternational Volume: 60 Pages: 599-607
  • Peer Reviewed
• [Journal Article] Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development. (2010)
  • Author(s): Oguma K, et al.
  • Journal Title: Future Oncology Volume: 6 Pages: 515-526
  • Peer Reviewed
• [Presentation] The role of inflammatory citykine TNF-α and microenvironment in mouse gastric tumorigenesis (2013)
  • Author(s): 大島浩子,大島正伸
  • Organizer: 第86回日本薬理学会学術総会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2013-03-21
• [Presentation] The role of inflammatory cytokine TNF-α and microenvironment in mouse gastric tumorigenesis (2013)
  • Author(s): 大島浩子、大島正伸
  • Organizer: 第86回日本薬理学会学術総会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Invited
• [Presentation] The role of inflammatory cytokine TNF in CD44 expression-associated mouse gastric tumorigenesis (2012)
  • Author(s): Oshima H, Yoshida GH, Ishikawa T, Saya H, and Oshima M.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] The role of TNF-α in PGE_2-induced tumorigenesis in gastric cancer mouse model (2012)
  • Author(s): Oshima H, Ishikawa T, and Oshima M
  • Organizer: なし
  • Place of Presentation: McCormick Place(USA)
  • Year and Date: 2012-04-02
• [Presentation] The role of TNF-α in PGE2-induced tumorigenesis in gastric cancer mouse model (2012)
  • Author(s): Oshima H, Ishikawa T, and Oshima M
  • Organizer: 103th AACR Annual Meeting
  • Place of Presentation: McCormick Place West（シカゴ）
• [Presentation] The role of inflammatory cytokine TNF in CD44 expression-associated mouse gastric tumorigenesis (2012)
  • Author(s): Oshima H, Yoshida GJ, Ishikawa T, Saya H, Oshima M
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Inflammatory responses and TNF-α in mouse gastric tumorigenesis (2011)
  • Author(s): Oshima H, and Oshima M
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-04
• [Presentation] Inflammatory responses and TNF-α in mouse gastric tumorigenesis (2011)
  • Author(s): Oshima H, et al
  • Organizer: 第70回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-04
• [Presentation] Inflammatory microenvironment by cooperation of PGE_2 and bacterial infection in mouse gastric tumors (2011)
  • Author(s): Oshima H, Kong D, Ju XiaoLi, and Oshima M
  • Organizer: 日本分子生物学会第11回春季シンポジウム/金沢国際がん生物学シンポジウム
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2011-05-25
• [Presentation] Inflammatory microenvironment by cooperation of PGE_2 and bacterial infection in mouse gastric tumors (2011)
  • Author(s): Oshima H, et al
  • Organizer: 第11回日本分子生物学会春季シンポジウム
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2011-05-25
• [Presentation] Downregulation of tumor suppressor microRNA in inflammatory microenvironment (2011)
  • Author(s): Oshima H, Kong D, Ishikawa T, and Oshima M
  • Organizer: 第1回発がんスパイラル国際シンポジウム
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2011-02-01
• [Presentation] Downregulation of tumor suppressor microRNA in inflammatory microenvironment. (2011)
  • Author(s): Oshima H, et al.
  • Organizer: 1^<st>International Symposium on Carcinogenic Spiral
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2011-02-01
• [Presentation] Inflammatory microenvironment by cooperation of PGE_2 and bacterial infection in mouse gastric tumors (2010)
  • Author(s): Oshima H, and Oshima M
  • Organizer: なし
  • Place of Presentation: Incheon Sheraton Hotel (韓国)
  • Year and Date: 2010-12-22
• [Presentation] Inflammatory microenvironment by cooperation of PGE_2 and bacterial infection in mouse gastric tumors. (2010)
  • Author(s): Oshima H, et al.
  • Organizer: 15^<th> Japan-Korea Cancer Research Workshbp
  • Place of Presentation: Incheon Sheraton Hotel(lncheon, Korea)
  • Year and Date: 2010-12-22
• [Presentation] Gastric tumorigenesis through bacterial infection and COX-2/PGE_2 signaling pathway (2010)
  • Author(s): 大島浩子、大島正伸
  • Organizer: 第69回日本癌学会学術集会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] Gastric tumorigenesis through bacterial infection and COX-2/PGE2signaling pathway.
  • Author(s): 大島浩子,大島正伸
  • Organizer: 第69回日本癌学会学術集会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪府)
• [Remarks] ホームページ
  • URL: http://genetics.w3.kanazawa-u.ac.jp
• [Remarks]
  • URL: http://genetics.w3.kanazawa-u.ac.jp/
• [Remarks]
  • URL: http://www.kanazawa-u.ac.jp/ganken/oshima/index.html
• [Patent(Industrial Property Rights)] がんの予防用または治療用物質のスクリーニング方法 (2013)
  • Inventor(s): 大島正伸、石川智夫、大島浩子
  • Industrial Property Number: 2013-030503
  • Filing Date: 2013-02-20