Elucidation of genomic distribution dynamics of DNA damage and repair in carcinogenesis process
| Project/Area Number |
22500997
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Carcinogenesis
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYOKUNI Shinya 名古屋大学, 大学院・医学系研究科, 教授 (90252460)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 実験動物モデル / ゲノム損傷 / 酸化ストレス / 発がん |
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| Research Abstract |
We developed a novel method to detectgenomic sites harboring DNA damage comprehensively and verified practical effectiveness of the method. We conducted immunoprecipitations with genomic DNA extracted from target cells of ferric nitrilotriacetate-induced rodent renal carcinogenesis model using antibodies against two types of representative oxidative modified bases, 8-OHdG and acrolein-dA, and analyzed genomic distributions of the oxidative DNA damages by the use of array-CGH.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.2012
Author(s)
Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer.2012
Author(s)
Liu Y, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
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Journal Title
PLoS One
Volume: 7
Issue: 8
Pages: e43403-e43403
DOI
Related Report
Peer Reviewed
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