| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
A genetically-engineered mouse model, containing mutant Kras expression and Tgfbr2 knockout, recapitulates histological features of human pancreatic cancer, demonstrating adenocarcinoma with abundant fibrosis. The murine pancreatic cancer cells secret CXCR2 ligands, which induce CTGF expression in the stromal fibroblasts, resulting in tumor promotion through angiogenesis. Inhibiting the tumor-stromal interactions in the tumor microenvironment demonstrated anti-tumor effect and can be a therapeutic option for pancreatic cancer. The pancreatic cancer tissues contain abundant macrophage infiltration, however, targeting the macrophages as a therapy of pancreatic cancer should be further investigated.
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