Targeting tumor microenvironment as a novel therapeutic strategy for pancreatic cancer using a genetically-engineered mouse model
| Project/Area Number |
22501004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IJICHI Hideaki 東京大学, 医学部附属病院, 助教 (70463841)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵癌 / 微小環境 / 腫瘍間質相互作用 / マクロファージ / 線維芽細胞 / CXCR2 / CTGF / 遺伝子改変マウス |
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| Research Abstract |
A genetically-engineered mouse model, containing mutant Kras expression and Tgfbr2 knockout, recapitulates histological features of human pancreatic cancer, demonstrating adenocarcinoma with abundant fibrosis. The murine pancreatic cancer cells secret CXCR2 ligands, which induce CTGF expression in the stromal fibroblasts, resulting in tumor promotion through angiogenesis. Inhibiting the tumor-stromal interactions in the tumor microenvironment demonstrated anti-tumor effect and can be a therapeutic option for pancreatic cancer. The pancreatic cancer tissues contain abundant macrophage infiltration, however, targeting the macrophages as a therapy of pancreatic cancer should be further investigated.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.2013
Author(s)
Ryota Takahashi, Yashuhiro Hirata,Kousuke Sakitani, Wachiko Nakata, Hiroto Kinoshita, Yoku Hayakawa, Hayato Nakagawa, Kei Sakamoto, Yoko Hikiba, Hideaki Ijichi , Harold L Moses, Shin Maeda, Kazuhiko Koike.
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Journal Title
Cancer Science
Volume: Vol.104
Pages: 337-344
Related Report
Peer Reviewed
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[Journal Article] Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.2011
Author(s)
Hideaki Ijichi, Anna Chytil, Agnieska E Gorska, Mary E Aakre, Brian Bierie, Motohisa Tada, Dai Mohri, Koji Miyabayashi, Yoshinari Asaoka, Shin Maeda, Tsuneo Ikenoue, Keisuke Tateishi, Christopher VE Wright, Kazuhiko Koike, Masao Omata, Harold L Moses.
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Journal Title
Journal of Clinical Investigation
Volume: Vol.121
Pages: 4106-4117
Related Report
Peer Reviewed
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