Study on functional significance of transcription factor GATA-6during oncogenic signal transduction
Project/Area Number |
22501007
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Tumor biology
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Research Institution | Shinshu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KAMATA Tohru 信州大学, 医学部, 教授 (40056304)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 転写因子 / GATA-6 / シグナル伝達 / GATA-6 / TOPORS / TOPORS / Nox1 |
Research Abstract |
We clarified that phosphorylation of GATA-6 and GATA-6-associated cofactor HMGB1 positively regulate the transcriptional machinery for Nox1 gene in oncogenic Ras signaling. We identified 719 genes upregulated byGATA-6 and 1161 genes downregulated by GATA-6 in colon cancer cell-line CaCo-2. We also clarified the molecular mechanism for transcriptional repression of TOPORS gene by GATA-6.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration.2010
Author(s)
Shinohara M., Adachi Y., Mitsushita J., Kuwabara M., Nagasawa A., Harada S., Furuta S., Zhang Y., Seheli K., Miyazaki H., Kamata T
Volume
Vol .285、No.7
Pages
4481-4488
NAID
URL
Related Report
Peer Reviewed
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