Analysis of physiological role of Wnt pathway activation inducedby Krtap13, a novel LRP6 binding protein

• Project/Area Number: 22501008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kyoto University
• Principal Investigator: YANAGAWA Shin-ichi 京都大学, ウイルス研究所, 助教 (70183978)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Wnt / Krtap13 / シグナル伝達 / ケラチン結合蛋白 / がん / LRP6 / 癌

Research Abstract

Keratin associated protein (Krtap) 13 binds to LRP6, a co-receptor for Wnt. Surprisingly, Krtap13 overexpression markedly stimulates Wnt signaling. Krtap13 induces co-clustering of LRP6 and Dvls, thereby recruiting Axin to the plasma membrane that leads to activation of Wn signaling. Transgenic mice were generated to analyze effect of Krtap13 overexpression in vivo.

Research Products

• [Journal Article] HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells (2013)
  • Author(s): Ma G, Yasunaga J-I, Fan J, Yanagawa S-I, Matsuoka M
  • Journal Title: Oncogene Volume: 32 Issue: 36 Pages: 4222-4230
  • DOI: 10.1038/onc.2012.450
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 20年前のWnt研究の現場はどうだったか (2013)
  • Author(s): 柳川伸一
  • Journal Title: 細胞工学 Volume: 406 Pages: 406-406
  • URL: http://gakken-mesh.jp/journal/detail/9784780901412.html
  • Peer Reviewed
• [Journal Article] ２０年前のWnt研究の現場は、どうだったか (2013)
  • Author(s): 柳川伸一
  • Journal Title: 細胞工学 Volume: 32 Pages: 406-406
• [Presentation] Analysis of Keratin associated protein13-induced activation of canonical Wnt pathway in vivo. (2012)
  • Author(s): 柳川伸一
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-13
• [Presentation] Analysis of Keratin-Associated Protein13-Induced Activation of Canonical Wnt Pathway in vivo (2012)
  • Author(s): 柳川伸一
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡
• [Presentation] Analysis of Keratin-associated proteinl3-induced activation of canonical Wnt signaling pathway in vivo (2011)
  • Author(s): 柳川伸一
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-16
• [Presentation] Analysis of Keratin associated protein13-induced activation of canonical Wnt signaling pathway in vivo. (2011)
  • Author(s): 柳川伸一
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-11-16
• [Presentation] Analysis of molecular mechanism underlying Keratin associated protein13-induced activation of canonical Wnt signaling pathway (2010)
  • Author(s): 柳川伸一
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Analysis of molecular mechanism underlying Keratin associated protein 13-induced activation of canonical Wnt signaling pathway (2010)
  • Author(s): 柳川伸一
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-12-09