| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
MUTYH, adenine DNA glycosylase excises adenine inserted opposite 8-oxoguanine (8-oxoG), a major form of spontaneous oxidative DNA damage, and whose deficiency is known to cause MUTYH-associated familial adenomatous polyposis. We have shown that accumulation of 8-oxoG in nuclear and mitochondrial DNA independently triggers two distinct MUTYH-dependent cell death programs. In the present study, we found that expression of MUTYH is regulated by p53 and identified functional p53-binding site in MUTYH gene. These results suggest that MUTYH is a potential mediator of p53 tumor suppression.
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