| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
UTF1 is expressed not only in embryonic stem cells (ESCs) but also in tumor cells as germ cell tumors. To treat the cancer, it is critical to clarify the mechanism maintaining the tumorigenicity. I previously demonstrated that UTF1 plays an important role to maintain the tumor character in ESCs. Because I hypothesize that the loss of function of UTF1 in ESCs may result in the loss of tumorigenicity, I generated the UTF1 knockout ESCs. Unfortunately, the UTF1 knockout ESCs still maintained the tumorigenicity. This result indicates that the genes in addition to UTF1 may contribute to the tumorigenicity of ESCs.
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