| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria via MALM (the Mieap-induced accumulation of lysosome-like organelles within mitochondria: the elimination of oxidized mitochondrial proteins) or MIV (Mieap-induced vacuole: the degradation of unhealthy mitochodria). In human cancer cells, the function is frequently inactivated, leading to the accumulation of unhealthy mitochondria and increase of reactive oxygen species (ROS) production by the mitochondria. The mitochondrial ROS may play a critical role in cancer initiation, progression, invasion and metastasis.
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