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Identification of essential molecules and elucidation of the mechanism for novel cancer immune evasion system: Research for biomarker for immunological response

Research Project

Project/Area Number 22501023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor immunology
Research InstitutionKyushu University

Principal Investigator

OKANO Shinji  九州大学, 大学病院, 臨床助教 (10380429)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords腫瘍免疫 / 免疫回避機構 / バイオマーカー / 癌
Research Abstract

We firstly found that a new clone, which have acquired the immune evasion potentials, emerges from the original neoplastic clone, which is susceptible to the tumor associated antigens-specific T cell response. This emergence of neoplastic clone is dependent on the T cell response. The new neoplastic cells have no change in the expression of MHC class I, TRP2, Gp100, IFN-γ (including functional response to IFN-γ), and Fas, but upregulate the expressions of sytl2, GATA1 and 2, and downregulate NGFR, suggesting that the molecules may be potential biomarkers in the immune evasion of neoplasm.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (57 results)

All 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 17 results) Presentation (34 results) Remarks (3 results)

  • [Journal Article] Fas-deficient fully allogeneic dendritic cells administered via an intratumoral injection route show efficient antitumor effects in murine models2013

    • Author(s)
      Okano S, Kondoh H, Toshima T, Nakagawara H, Yoshizumi T, Soejima Y, Shirabe K, Harada M, Yoshikai Y, and Maehara Y
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 104(1) Pages: 15-26

    • NAID

      120005227184

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD4 T cell-mediated masking effects of the immunogenicity of tumor-associated antigens are qualitatively and quantitatively different depending on the individual antigens2013

    • Author(s)
      Okano S, Matsumoto Y, Yoshiya S, Yamashita Y, HarimotoN, IkegamiT, ShirabeK, HaradaM, YoshikaiY, and Maehara Y
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 104(1) Pages: 1-14

    • NAID

      120005227183

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fas-deficient fully allogeneic dendritic cells administered via an intratumoral injection route show efficient antitumor effects in murine models.2013

    • Author(s)
      Okano S, Kondoh H, Toshima T, Nakagawara H, Yoshizumi T, Soejima Y, Shirabe K, Harada M, Yoshikai Y, Maehara Y
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 104 Pages: 15-26

    • NAID

      120005227184

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD4 T cell-mediated masking effects of the immunogenicity of tumor-associated antigens are qualitatively and quantitatively different depending on the individual antigens.2013

    • Author(s)
      Okano S, Matsumoto Y, Yoshiya S, Yamashita Y, Harimoto N, Ikegami T, Shirabe K, Harada M, Yoshikai Y, Maehara Y
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 104 Pages: 1-14

    • NAID

      120005227183

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells2012

    • Author(s)
      Harashima N, Inao T, Imamura R, Okano S, Suda T, Harada M
    • Journal Title

      Cancer Immunol Immunother

      Volume: 61(5) Pages: 667-676

    • NAID

      120005982742

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アジュバントとしてのセンダイウイルス2012

    • Author(s)
      岡野慎士
    • Journal Title

      月刊臨床免疫・アレルギー科

      Volume: 57 Pages: 87-94

    • NAID

      40019192531

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I:C), on human breast cancer2012

    • Author(s)
      Inao T, Harashima N, Monma H, Okano S, Itakura M, Tanaka T, Tajima Y, Harada M
    • Journal Title

      Breast Cancer Res Treat

      Volume: 134(1) Pages: 89-100

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiangiogenic tumor therapy by DNA vaccine inducing aquaporin-1-specific CTL based on ubiquitin-proteasome system in mice2012

    • Author(s)
      Chou B, Hiromatsu K, Okano S, Ishii K, Duan X, Sakai T, Murata S, Tanaka K, Himeno K
    • Journal Title

      J Immunol

      Volume: 189(4) Pages: 1618-1626

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 固形腫瘍に対する新規免疫療法の開発当科における第I 相臨床試験の現状-2012

    • Author(s)
      土方 康基, 村橋(伊賀) 睦了,岡崎 利彦, 田中 芳浩, 大平 公亮, 岡野慎士, 久野 晃聖, 高橋 淳, 丸本 朋稔, 井上 博之, 谷 憲三朗
    • Journal Title

      臨床血液

      Volume: 53(5) Pages: 487-492

    • NAID

      130004501683

    • Related Report
      2012 Final Research Report
  • [Journal Article] Antiangiogenic tumor therapy by DNA vaccine inducing aquaporin-1-specific CTL based on ubiquitin-proteasome system in mice.2012

    • Author(s)
      Chou B, Hiromatsu K, Okano S, Ishii K, Duan X, Sakai T, Murata S, Tanaka K, Himeno K.
    • Journal Title

      J Immunol

      Volume: 189 Issue: 4 Pages: 1618-26

    • DOI

      10.4049/jimmunol.1101971

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I : C), on human breast cancer2012

    • Author(s)
      Harada M., et al.(8人中8番目)
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: (in press) Issue: 1 Pages: 89-100

    • DOI

      10.1007/s10549-011-1930-3

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the PI3 K/Akt pathway and autophagy in TLR3 sig naling-induced apoptosis and growth arr est of human prostate cancer cells2012

    • Author(s)
      Harashima, N., Inao, T., Imamura, R., et. al.
    • Journal Title

      Cancer Immunol. Immunother

      Volume: (in press) Issue: 5 Pages: 667-676

    • DOI

      10.1007/s00262-011-1132-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of novel immune therapies for solid tumors: phase I clinical trials in a single institute.2012

    • Author(s)
      Hijikata Y, Murahashi-Iga M, Okazaki T, Tanaka Y, Odaira K, Okano S, Hisano T, Takahashi A, Marumoto T, Inoue H, Tani K.
    • Journal Title

      Rinsho Ketsueki.

      Volume: 53 Pages: 487-92

    • NAID

      130004501683

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Roles of the PI3K/Akt pathway and autophagy in TLR3 sign aling-induced apoptosis and growth arrest of human prostate cancer cells2012

    • Author(s)
      Harashima N., Okano S., et al
    • Journal Title

      Cancer Immunol Immunother

      Volume: (Epub)(in press)

    • NAID

      120005982742

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus2011

    • Author(s)
      Okano S, Yonemitsu Y, Shirabe K, Kakeji Y, Maehara Y, Harada M, Yoshikai Y, Inoue M, Hasegawa M, Sueishi K
    • Journal Title

      J Immunol

      Volume: 186(3) Pages: 1828-1839

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intratumoral neoadjuvant immunotherapy using IL-12 and dendritic cells is an effective strategy to control recurrence of murine hepatocellular carcinoma in immunosuppressed mice2010

    • Author(s)
      Kayashima H, Toshima T, Okano S, Taketomi A, Harada N, Yamashita Y, Tomita Y, Shirabe K, Maehara Y
    • Journal Title

      J Immunol

      Volume: 185(1) Pages: 698-708

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semi-allogeneic dendritic cells injected via the intratumoural injection route show efficient antitumour effects in cooperation with host-derived professional antigen-presenting cells2010

    • Author(s)
      Kondoh H, Okano S, Yoshida K, Yonemitsu Y, Tomita Y, Yoshikai Y, Wake N, Sueishi K
    • Journal Title

      Scand J Immunol

      Volume: 72(6) Pages: 476-490

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intratumoral neoadjuvant immunotherapy using IL-12 and dendritic cells is an effective strategy to control recurrence of murine hepatocellular carcinoma in immu nosuppressed mice.2010

    • Author(s)
      Kayashima H., Okao S., et al.
    • Journal Title

      J Immunol.

      Volume: 185 Pages: 698-708

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semi-allogeneic dendritic cells injected via the intratumoural injection route show efficient antitumour effects in cooperation with host-derived professional antigen-presenting cells.2010

    • Author(s)
      Kondoh H., Okano S., et al.
    • Journal Title

      Scand J Immunol

      Volume: 72 Pages: 476-490

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Provision of Continuous Maturation Signaling to Dendritic Cells by RIG-I-Stimulating Cytosolic RNA Synthesis of Sendai Virus.2010

    • Author(s)
      Okano S., et al.
    • Journal Title

      J Immunol.

      Volume: 185 Pages: 1828-1839

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2012

    • Author(s)
      Okano S.
    • Organizer
      平成23年度「個体レベルでのがん研究支援活動」ワークショップ
    • Place of Presentation
      大津市琵琶湖ホテル
    • Year and Date
      2012-01-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 能動免疫療法による免疫回避機構獲得細胞の出現に関する免疫病理学的検討2012

    • Author(s)
      岡野慎士 、居石克夫
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Cancer cells to evade T-cell-response emerge de novo during dormant state after cancer. Immunotherapy2012

    • Author(s)
      Okano S
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道
    • Related Report
      2012 Final Research Report
  • [Presentation] Inhibition of autophagy augments cancer cell death induced by an adjuvant receptor ligand, poly(I:C)2012

    • Author(s)
      Harashima Nanae, Inao Touko, Okano Shinji, Harada Mamoru
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道
    • Related Report
      2012 Final Research Report
  • [Presentation] 能動免疫療法による免疫回避機構獲得細胞の出現に関する免疫病理学的検討2012

    • Author(s)
      岡野慎士 、居石克夫
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cancer cells to evade T-cell-response emerge de novo during dormant state after cancer immunotherapy2012

    • Author(s)
      Shinji Okano, Nanae Harashima, Mamoru Harada.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibition of autophagy augments cancer cell death induced by an adjuvant receptor ligand, poly(I:C).2012

    • Author(s)
      Harashima Nanae, Inao Touko, Okano Shinji, Harada Mamoru.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2011

    • Author(s)
      Okano S., et al
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2011

    • Author(s)
      Okano S. et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of embryonal carcinoma cells emerged in the process of IPSC generation from common marmoset fibroblasts2011

    • Author(s)
      Yamaguchi S, Okano S, et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Anti-tumor effect and autophagy in human breast cancer cells after the transfection with poly(I;C)2011

    • Author(s)
      Inao T, Okano S, et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2011

    • Author(s)
      Okano S., et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of embryonal carcinoma cells emerged in the process of IPSC generation from common marmoset fibroblasts2011

    • Author(s)
      Yamaguchi S, Okano S, et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Anti-tumor effect and autophagy in human breast cancer cells after the transfection with poly(I;C)2011

    • Author(s)
      Inao T, Okano S, et al
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2011

    • Author(s)
      Okano S. et al
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2011

    • Author(s)
      Okano S., et al
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2011-07-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 乳癌細胞に発現するアジュバント受容体を利用したimmunogenic cancer cell deathの誘導2011

    • Author(s)
      原嶋奈々江、岡野慎士ら
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳癌細胞に発現するアジュバント受容体を利用したimmunogenic cancer cell deathの誘導2011

    • Author(s)
      原嶋奈々江、岡野慎士, ら
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 移植後肝細胞癌再発制御におけるIL12と樹状細胞を用いた術前補助免疫療法の抗腫瘍効果の分子病理学的検討2011

    • Author(s)
      岡野慎士ら
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 移植後肝細胞癌再発制御におけるIL12と樹状細胞を用いた術前補助免疫療法の抗腫瘍効果の分子病理学的検討2011

    • Author(s)
      岡野慎士, ら
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] The roles of host-derived antigen presenting cells (hAPC) and in jected dendritic cells (iDC) in intratumoral activated DC therapy (ITADT).2011

    • Author(s)
      Okano S.
    • Organizer
      「個体レベルでのがん研究支援活動」ワークショップ
    • Place of Presentation
      大津市琵琶湖ホテル
    • Year and Date
      2011-02-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2010

    • Author(s)
      Okano S. et al
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] RIG-1-stimulating cytosolic RNA synthesis of Sendai virus (rSeV) is a novel stimulant for human dendritic cells (DC)2010

    • Author(s)
      Okano S. et al
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] RIG-1-stimulating cytosolic RNA synthesis of Sendai virus (rSeV) is a novel stimulant for human dendritic cells (DC)2010

    • Author(s)
      Okano S., et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Provision of continuous maturation signaling to dendritic cells (DC) by RIG-1-stimulating cytosolic RNA synthesis of recombinant Sendai virus (rSeV)2010

    • Author(s)
      Okano S. et al
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Provision of continuous maturation signaling to dendritic cells (DC) by RIG-1-stimulating cytosolic RNA synthesis of recombinant Sendai virus (rSeV)2010

    • Author(s)
      Okano S., et al.
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍内樹状細胞(DC)投与療法における宿主抗原提示細胞(hAPC)と投与DCの役割に関する免疫病理学的検討2010

    • Author(s)
      岡野慎士ら
    • Organizer
      第7回日本病理学会カンファレンス
    • Place of Presentation
      岡山
    • Year and Date
      2010-08-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 腫瘍内樹状細胞(DC)投与療法における宿主抗原提示細胞(hAPC)と投与DCの役割に関する免疫病理学的検討2010

    • Author(s)
      岡野慎士, ら
    • Organizer
      第7回日本病理学会カンファレンス
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] RIG-1-stimulating cytosolic RNA synthesis of Sendai virus (rSeV) is a novel stimulant for human dendritic cells (DC)2010

    • Author(s)
      Okano S. et al
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2010-07-22
    • Related Report
      2012 Final Research Report
  • [Presentation] RIG-1-stimulating cytosolic RNA synthesis of Sendai virus(rSeV)is a novel stimulant for human dendritic cells(DC)2010

    • Author(s)
      Okano S., et al.
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 能動免疫療法による免疫回避機構獲得細胞の出現に関する免疫病理学的検討2010

    • Author(s)
      岡野慎士ら
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 能動免疫療法による免疫回避機構獲得細胞の出現に関する免疫病理学的検討2010

    • Author(s)
      岡野慎士, ら
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] The roles of host-derived antigen presenting cells (hAPC) and injected dendritic cells (iDC) in intratumoral activated DC therapy (ITADT)2010

    • Author(s)
      Okano S
    • Organizer
      「個体レベルでのがん研究支援活動」ワークショップ
    • Place of Presentation
      大津
    • Year and Date
      2010-02-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2010

    • Author(s)
      Okano S
    • Organizer
      平成23年度「個体レベルでのがん研究支援活動」ワークショップ
    • Place of Presentation
      大津
    • Year and Date
      2010-01-19
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/pathol1/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/pathol1/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/pathol1/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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