Identification of essential molecules and elucidation of the mechanism for novel cancer immune evasion system: Research for biomarker for immunological response
| Project/Area Number |
22501023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
OKANO Shinji 九州大学, 大学病院, 臨床助教 (10380429)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腫瘍免疫 / 免疫回避機構 / バイオマーカー / 癌 |
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| Research Abstract |
We firstly found that a new clone, which have acquired the immune evasion potentials, emerges from the original neoplastic clone, which is susceptible to the tumor associated antigens-specific T cell response. This emergence of neoplastic clone is dependent on the T cell response. The new neoplastic cells have no change in the expression of MHC class I, TRP2, Gp100, IFN-γ (including functional response to IFN-γ), and Fas, but upregulate the expressions of sytl2, GATA1 and 2, and downregulate NGFR, suggesting that the molecules may be potential biomarkers in the immune evasion of neoplasm.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] 固形腫瘍に対する新規免疫療法の開発当科における第I 相臨床試験の現状-2012
Author(s)
土方 康基, 村橋(伊賀) 睦了,岡崎 利彦, 田中 芳浩, 大平 公亮, 岡野慎士, 久野 晃聖, 高橋 淳, 丸本 朋稔, 井上 博之, 谷 憲三朗
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Journal Title
臨床血液
Volume: 53(5)
Pages: 487-492
NAID
Related Report
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[Journal Article] Development of novel immune therapies for solid tumors: phase I clinical trials in a single institute.2012
Author(s)
Hijikata Y, Murahashi-Iga M, Okazaki T, Tanaka Y, Odaira K, Okano S, Hisano T, Takahashi A, Marumoto T, Inoue H, Tani K.
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Journal Title
Rinsho Ketsueki.
Volume: 53
Pages: 487-92
NAID
Related Report
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