Analysis of a role of Hsp90α in antigen cross presentation
| Project/Area Number |
22501027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Okayama University (2011-2012)
The Institute of Physical and Chemical Research (2010) |
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Principal Investigator |
UDONO Heiichiro 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50260659)
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| Co-Investigator(Kenkyū-buntansha) |
今井 孝 群馬大学, 医学部, 助教 (10513434)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Hsp90 / クロスプレゼンテーション / 樹状細胞 / ノックアウトマウス / 抗原提示 / エンドソーム / エンドゾーム / HSF-1 / Hsp90α / クロスプライミング |
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| Research Abstract |
Analysis of a role of Hsp90α in antigen cross presentation In antigen cross-presentation, dendritic cells (DCs) take up extracellular antigens (Ag) and translocate them from the endosome to the cytosol for proteasomal degradation. The molecules responsible for Ag translocation are unknown. By using Hsp90α KO mice, we demonstrated that HSP90 is essential in pulling endosomal Ag out into the cytosol.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.2013
Author(s)
Eikawa, S., Kakimi, K., Idobe, M., Kuzushima, K., Luescher, I., Ohue, Y., Ikeuchi, K., Uenaka, A., Nishikawa, H., Udono, H., Oka, M., and Nakayama, E.
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Journal Title
Int. J. Cancer
Volume: 132(2)
Issue: 2
Pages: 345-54
DOI
Related Report
Peer Reviewed
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[Journal Article] HSP90α deficiency does not affect Ig gene hypermutation and class switch but causes enhanced MHC class II antigen presentation2012
Author(s)
Li, Y., Li, S., Hoshino, M., Ishikawa, R., Kajiwara, C., Gao, X., Zhao, Y., Ishido, S., Udono, H., Wang, J. -Y.
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Journal Title
Int. Immunol.
Volume: 24
Issue: 12
Pages: 751-758
DOI
Related Report
Peer Reviewed
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[Presentation] Inhibition of regulatory T-cell migration by ELR motif-binding peptide.2012
Author(s)
Shingo Eikawa, Koji Kurose, Hirofumi Matsumoto, Midori Isobe, Akiko Uenaka, Shusaku Mizukami, Chihiro Yamazaki, Yoshihiro Oheu, Mikio Oka, Heiichiro Udono, Eiichi Nakayama
Organizer
第71回日本癌学会学術総会
Place of Presentation
札幌
Year and Date
2012-09-21
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