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Establishment of cancer therapytargeted for DNA dependent protein kinase and investigation of its predictive factor

Research Project

Project/Area Number 22501031
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor diagnosis
Research InstitutionSaga University

Principal Investigator

ARAGANE Naoko  佐賀大学, 医学部, 講師 (20321846)

Co-Investigator(Kenkyū-buntansha) SUEOKA Eizaburo  佐賀大学, 医学部, 准教授 (00270603)
IWANAGA Kentaro  佐賀大学, 医学部, 客員研究員 (60380755)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsバイオマーカー / 肺癌 / DNA依存性キナーゼ / トポイソメラーゼIIα / DNA二重鎖切断 / 成人T細胞性白血病
Research Abstract

NK314, a dual inhibitor of DNA dependent protein kinase (DNA-PK) and topoisomerase IIαpotently inhibited cell growth of adult T cell leukemia and lung cancer cell lines. The inhibitory effect was mediated through enhancement of DNA double strand breaks and prolonged inhibitory effect ofDNA repair. As for the predictive factors for DNA-PK inhibitors, protein level of hnRNP B1, an RNA binding protein, was strongly associated with that of DNA-PKcs. However, the inhibitory effect of cell growth of lung cancer cells was not statistically associated with protein levels of DNA-PKcs nor hnRNP B1. Further investigation for seeking the predictive factors would be needed.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase Iiαand DNA-dependent protein kinase2011

    • Author(s)
      Hisatomi T,Sueoka-Aragane N,Sato A,Tomimasu R, Ide M, Kurimasa A,Okamoto K, Kimura S,Sueoka E.
    • Journal Title

      Blood

      Volume: 117 Pages: 3575-84

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase IIα and DNA-dependent protein kinase2011

    • Author(s)
      Hisatomi T, Sueoka-Aragane N, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 3575-3584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] DNA dependent protein kinase as a new molecular target for treatment of non-small cell lung cancer2012

    • Author(s)
      Naoko Sueoka-Aragane, Akemi Sato,Kentaro Iwanaga, Naomi Kobayashi,Shinya Kimura,Eisaburo Sueoka
    • Organizer
      American Association for Cancer Research
    • Related Report
      2012 Final Research Report
  • [Presentation] Dual targeting therapy on topoisomerase IIa and DNA-dependent protein kinase is a promising strategy for adult T cell leukemia-lymphoma.2012

    • Author(s)
      Takashi Hisatomi,Naoko Aragane,Akemi Sato, Masaru Ide, Kazuya Okamoto, Shinya Kimura, Eisaburo Sueoka
    • Organizer
      The 10th Japan-Korea Joint symposium on Cancer and Ageing Research
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of hypoxia inducible factors on maintenance of hematopoietic stem cells and leukemogenesis2012

    • Author(s)
      Sueoka E,Ide M,Sueoka-Aragane N, SatoA,Nakamura H, Sotomaru Y, Taya C, Yonekawa H,Nakachi K,Kubota Y,Kimura S,Tanimoto K
    • Organizer
      2012 Tumor Microenvironment GCRC International Symposium
    • Place of Presentation
      Seoul
    • Related Report
      2012 Final Research Report
  • [Presentation] Taylor made treatment using monitoring biomarkers for acquired resistance to molecular targeted therapy2012

    • Author(s)
      荒金 尚子
    • Organizer
      2012 Tumor Microenvironment GCRC International Symposium
    • Place of Presentation
      韓国ソウル
    • Related Report
      2012 Annual Research Report
  • [Presentation] 耐性原因マーカーのモニタリングによるテイラーメイド治療2012

    • Author(s)
      荒金 尚子 et al
    • Organizer
      第16回日本がん分子標的治療学会.
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA dependent protein kinase as a new molecular target for treatment of non-small cell lung cancer2012

    • Author(s)
      荒金尚子, et al
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      米国シカゴ
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dual targeting therapy on topoisomerase IIα and DNA-dependent protein kinase is a promising strategy for adult T-cell leukemia-lymphom2012

    • Author(s)
      久富崇、荒金尚子, et al
    • Organizer
      The 10th Korea-Japan Joint Symposium on Cancer and Aging Research
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Shinya Kimura Overexpression of hnRNP B1 inhibits DNA repair by interaction with DNA-dependent protein kinase complex in adult T-cell leukemia.2011

    • Author(s)
      Eisaburo Sueoka, Takashi Hisatomi, Naoko Sueoka-Aragane, Akemi Sato, Rika Tomimasu, Masaru Ide2
    • Organizer
      The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA-dependent protein kinase as a promising molecular target for the treatment of adult T-cell leukemia-lymphoma2011

    • Author(s)
      Takashi Hisatomi, Naoko Sueoka-Aragane, Akemi Sato, Rika Tomimasu, Masaru Ide, Shinya Kimura and Eisaburo Sueoka
    • Organizer
      ヨーロッパ血液学会
    • Place of Presentation
      ロンドン(英国)
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA-dependent protein kinase as a promising molecular target for the treatment of adult T-cell leukemia-lymphoma2011

    • Author(s)
      久富崇、荒金尚子, et al
    • Organizer
      ヨーロッパ血液学会
    • Place of Presentation
      英国ロンドン
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA dependent protein kinase as a new molecular target for treatment of non-small cell lung cancer2011

    • Author(s)
      末岡栄三朗、荒金尚子, et al
    • Organizer
      The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA-dependent protein kinase as a molecular target of chemotherapy on hematological malignancy.2010

    • Author(s)
      末岡 栄三朗
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-10
    • Related Report
      2012 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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