Detection of Circulating Tumor Cells in peripheral blood and evaluation of xenograft model using NOG mouse
| Project/Area Number |
22501032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Kagoshima University |
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Principal Investigator |
UENOSONO Yoshikazu 鹿児島大学, 大学院・医歯学総合研究科, 特任准教授 (60398279)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGITA Shigehiro 鹿児島大学, 医学部・歯学部付属病院, 特任助教 (20444903)
ARIGAMI Takaaki 鹿児島大学, 医学部・歯学部付属病院, 助教 (40527058)
NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577)
有馬 豪男 鹿児島大学, 医学部・歯学部附属病院, 助教 (90418856)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 微小癌細胞 / NOG マウス / 抗癌性感受性試験 / NOGマウス / 抗癌剤感受性試験 / GellSearch / CellSearch |
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| Research Abstract |
We detected circulating tumor cells (CTCs) in peripheral blood of patient with cancer and clarified the change and clinical significance and tried the inspection with the NOG mouse and the manufacture of the survival model from CTCs. I succeeded in the detection of CTCs and imaging in 60% of unresectable gastric cancer patients, 27% of unresectable esophageal cancer patients, 20% of unresectable pancreatic cancer patients using CellSearch system. I confirmed in particular that the cancer cells which I gave in the abdominal cavity of the NOG mouse moved into blood via peritoneum early because a positive percentage of CTC of the patient with the peritoneum dissemination was high in stomach cancer patients.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Expression of stnniocalcin 1 as a potential biomarker of gastric cancer2012
Author(s)
Arigami T, Uenosono Y , Ishigami S, Hagihara T, Haraguchi N, Matsushita D, Yanagita S, Nakajo A, Okumura H, Hokita S, Natsugoe S
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Journal Title
Oncology
Volume: 83(3)
Issue: 3
Pages: 158-64
DOI
Related Report
Peer Reviewed
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[Journal Article] Sentinel node navigation surgery is acceptable for clinical T1 and N0 esophageal cancer2011
Author(s)
Uenosono Y., Arigami T., Yanagita S., Kozono T., Arima H., Hirata M., Kita Y., Uchikado Y., Okumura H., Matsumoto M., Natsugoe S
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Journal Title
Ann Surg Oncol
Volume: 18(7)
Issue: 7
Pages: 2003-9
DOI
Related Report
Peer Reviewed
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[Presentation] 胃癌における血中循環癌細胞検出および Her2 発現の検討2012
Author(s)
上之園芳一, 有上貴明, 柳田茂寛, 小園勉, 有馬豪男, 萩原貴彦, 原口尚士, 松下大輔, 石神純也, 帆北修一, 夏越祥次
Organizer
第112回日本外科学会定期学術集会
Place of Presentation
千葉市
Year and Date
2012-04-13
Related Report
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[Presentation] 胃癌患者における血中循環癌細胞と予後に関する検討2011
Author(s)
上之園芳一, 有上貴明, 柳田茂寛, 萩原貴彦, 原口尚士, 小園勉, 平田宗嗣, 有馬豪男, 石神純也, 帆北修一, 夏越祥次
Organizer
第83回日本胃癌学会総会
Place of Presentation
三沢市
Year and Date
2011-03-04
Related Report
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[Presentation] 胃癌患者における血中循環癌細胞の検出の意義2010
Author(s)
上之園芳一, 有上貴明, 平田宗嗣, 萩原貴彦, 柳田茂寛, 有馬豪男, 小園 勉, 石神純也, 帆北修一, 愛甲 孝, 夏越祥次
Organizer
第110回日本外科学会定期学術集会
Place of Presentation
名古屋市
Year and Date
2010-04-08
Related Report
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