| Project/Area Number |
22501032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Kagoshima University |
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Principal Investigator |
UENOSONO Yoshikazu 鹿児島大学, 大学院・医歯学総合研究科, 特任准教授 (60398279)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGITA Shigehiro 鹿児島大学, 医学部・歯学部付属病院, 特任助教 (20444903)
ARIGAMI Takaaki 鹿児島大学, 医学部・歯学部付属病院, 助教 (40527058)
NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577)
有馬 豪男 鹿児島大学, 医学部・歯学部附属病院, 助教 (90418856)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 微小癌細胞 / NOG マウス / 抗癌性感受性試験 / NOGマウス / 抗癌剤感受性試験 / GellSearch / CellSearch |
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| Research Abstract |
We detected circulating tumor cells (CTCs) in peripheral blood of patient with cancer and clarified the change and clinical significance and tried the inspection with the NOG mouse and the manufacture of the survival model from CTCs. I succeeded in the detection of CTCs and imaging in 60% of unresectable gastric cancer patients, 27% of unresectable esophageal cancer patients, 20% of unresectable pancreatic cancer patients using CellSearch system. I confirmed in particular that the cancer cells which I gave in the abdominal cavity of the NOG mouse moved into blood via peritoneum early because a positive percentage of CTC of the patient with the peritoneum dissemination was high in stomach cancer patients.
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