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Detection of Circulating Tumor Cells in peripheral blood and evaluation of xenograft model using NOG mouse

Research Project

Project/Area Number 22501032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor diagnosis
Research InstitutionKagoshima University

Principal Investigator

UENOSONO Yoshikazu  鹿児島大学, 大学院・医歯学総合研究科, 特任准教授 (60398279)

Co-Investigator(Kenkyū-buntansha) YANAGITA Shigehiro  鹿児島大学, 医学部・歯学部付属病院, 特任助教 (20444903)
ARIGAMI Takaaki  鹿児島大学, 医学部・歯学部付属病院, 助教 (40527058)
NATSUGOE Shoji  鹿児島大学, 医歯学総合研究科, 教授 (70237577)
有馬 豪男  鹿児島大学, 医学部・歯学部附属病院, 助教 (90418856)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords微小癌細胞 / NOG マウス / 抗癌性感受性試験 / NOGマウス / 抗癌剤感受性試験 / GellSearch / CellSearch
Research Abstract

We detected circulating tumor cells (CTCs) in peripheral blood of patient with cancer and clarified the change and clinical significance and tried the inspection with the NOG mouse and the manufacture of the survival model from CTCs. I succeeded in the detection of CTCs and imaging in 60% of unresectable gastric cancer patients, 27% of unresectable esophageal cancer patients, 20% of unresectable pancreatic cancer patients using CellSearch system. I confirmed in particular that the cancer cells which I gave in the abdominal cavity of the NOG mouse moved into blood via peritoneum early because a positive percentage of CTC of the patient with the peritoneum dissemination was high in stomach cancer patients.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (22 results) (of which Invited: 2 results)

  • [Journal Article] Clinical Significance of Lymph Node Micrometastasis in Gastric Cancer2012

    • Author(s)
      Arigami T, Uenosono Y, Yanagita S, Nakajo A, Ishigami S, Okumura H, Kijima Y, Ueno S, Natsugoe S
    • Journal Title

      Ann Surg Oncol

      Volume: 20 Issue: 2 Pages: 515-21

    • DOI

      10.1245/s10434-012-2355-x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of stnniocalcin 1 as a potential biomarker of gastric cancer2012

    • Author(s)
      Arigami T, Uenosono Y , Ishigami S, Hagihara T, Haraguchi N, Matsushita D, Yanagita S, Nakajo A, Okumura H, Hokita S, Natsugoe S
    • Journal Title

      Oncology

      Volume: 83(3) Issue: 3 Pages: 158-64

    • DOI

      10.1159/000341390

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of stanniocalcin 1 as a potential biomarker of gastric cancer.2012

    • Author(s)
      Arigami Takaaki
    • Journal Title

      Oncology

      Volume: 83 Pages: 158-164

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of lymph node micrometastasis in gastric cancer.2012

    • Author(s)
      Arigami Takaaki
    • Journal Title

      Annals of Surgical Oncology

      Volume: 20 Pages: 515-521

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of BMP-7 in human gastric cancer and its clinical significance2011

    • Author(s)
      Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S
    • Journal Title

      Br J Cancer

      Volume: 104 Issue: 4 Pages: 714-718

    • DOI

      10.1038/sj.bjc.6606075

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] B7-H3 expression in gastric cancer: A novel molecular blood marker for detecting tumor cells2011

    • Author(s)
      Arigami T, Uenosono Y, Hirata M, Yanagita S, Ishigami S, Natsugoe S
    • Journal Title

      Cancer Sci

      Volume: 102(1019-1024) Issue: 5 Pages: 1019-1024

    • DOI

      10.1111/j.1349-7006.2011.01877.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sentinel node navigation surgery is acceptable for clinical T1 and N0 esophageal cancer2011

    • Author(s)
      Uenosono Y., Arigami T., Yanagita S., Kozono T., Arima H., Hirata M., Kita Y., Uchikado Y., Okumura H., Matsumoto M., Natsugoe S
    • Journal Title

      Ann Surg Oncol

      Volume: 18(7) Issue: 7 Pages: 2003-9

    • DOI

      10.1245/s10434-011-1711-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sentinel node navigation surgery is acceptable for clinical T1 and N0 esophageal cancer2011

    • Author(s)
      Uenosono Y, Arigami T, Yanagita S., et al
    • Journal Title

      Ann Surg Oncol

      Volume: 18(7) Pages: 2003-2009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 未分化型早期胃癌におけるESD適応拡大へのSentinel Node理論の応用2011

    • Author(s)
      上之園芳一, 有上貴明, 柳田茂寛, ほか
    • Journal Title

      消化器内科

      Volume: 53 Pages: 394-399

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Clinical significance of the B7-H4 coregulatory molecule as a novel prognostic marker in gastric cancer2011

    • Author(s)
      Arigami T, Uenosono Y, Ishigami S, et al
    • Journal Title

      World J Surg

      Volume: 35 Pages: 2051-2057

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis2010

    • Author(s)
      Arigami T, Uenosono Y, Hirata M, Hagihara T, Yanagita S, Ishigami S, Natsugoe S
    • Journal Title

      J Surg Oncol

      Volume: 102 Issue: 7 Pages: 748-752

    • DOI

      10.1002/jso.21722

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 消化器癌における微小転移を含めたリンパ節転移の評価2010

    • Author(s)
      上之園芳一, 愛甲 孝, 有上貴明, 柳田茂寛, 有馬豪男, 石神純也, 夏越祥次
    • Journal Title

      病理と臨床

      Volume: 28巻 6号

    • Related Report
      2012 Final Research Report
  • [Journal Article] 消化器癌における微小転移を含めたリンパ節転移の評価2010

    • Author(s)
      上之園芳一, 愛甲孝, 有上貴明, 他
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 648-653

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Utility of the Gene Search breast lymph node assay for the rapid evaluation of sentinel lymph nodes in breast cancer2010

    • Author(s)
      Funasako Y, Uenosono Y, Hirata M, et al
    • Journal Title

      Cancer

      Volume: 116 Pages: 4450-4455

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis.2010

    • Author(s)
      Arigami T, Uenosono Y, Hirata M, et al.
    • Journal Title

      J Surg Oncol

      Volume: 102 Pages: 748-752

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胃癌における CTCs の存在意義と HER2 発現解析による臨床応用への展望2012

    • Author(s)
      上之園芳一
    • Organizer
      第50回日本癌治療学会学術集会(ランチョンセミナー)
    • Place of Presentation
      横浜市
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical significance of circulating tumor cells in blood from patients with gastric cancer2012

    • Author(s)
      Uenosono Y.
    • Organizer
      5th World Circulating Tumor Cell Summit
    • Place of Presentation
      Asia, Singapore
    • Year and Date
      2012-08-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃癌における血中循環癌細胞検出および Her2 発現の検討2012

    • Author(s)
      上之園芳一, 有上貴明, 柳田茂寛, 小園勉, 有馬豪男, 萩原貴彦, 原口尚士, 松下大輔, 石神純也, 帆北修一, 夏越祥次
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃癌患者における血中循環癌細胞による予後への影響2011

    • Author(s)
      上之園芳一, その他
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃癌における血中遊離癌細胞および洗浄腹水RT-PCR診断による腹膜播種予測の検討2011

    • Author(s)
      上之園芳一, その他
    • Organizer
      第16回日本外科病理学会学術集会
    • Place of Presentation
      大阪ガーデンパレス(大阪市)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical Significance of Circulating Tumor Cells in blood from Patients with Gastric Cancer2011

    • Author(s)
      Uenosono Y., Arigami T., Yanagita S., Kozono T., Hagihara T., Haraguchi N., Ishigami S., Hokita S., Natsugoe S.
    • Organizer
      8th International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka Japan
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical significance of circulating tumor cells in blood from patients with gastric cancer2011

    • Author(s)
      Uenosono Y., Arigami T., Yanagita S., Arima H., Hirata M., Hagihara T., Ishigami S., Natsugoe S.
    • Organizer
      International Surgical Week 2011
    • Place of Presentation
      Yokohama Japan
    • Year and Date
      2011-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical significance of circulating tumor cells in blood from patients with gastric cancer2011

    • Author(s)
      Uenosono Y., Ari garni T., Yanagita S., et al
    • Organizer
      International Surgical Week 2011
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃癌患者における血中循環癌細胞と予後に関する検討2011

    • Author(s)
      上之園芳一, その他
    • Organizer
      第66回日本消化器外科学会定期学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-07-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Extended Indication for ESD with Sentinel Node Biopsy in Early Gastric Cancer2011

    • Author(s)
      Uenosono Y., Arigami T., Yanagita S., et al
    • Organizer
      The 9th International Gastric Cancer Congress
    • Place of Presentation
      COEX (Seoul、Korea)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃癌患者における血中循環癌細胞と予後に関する検討2011

    • Author(s)
      上之園芳一, 有上貴明, 柳田茂寛, 萩原貴彦, 原口尚士, 小園勉, 平田宗嗣, 有馬豪男, 石神純也, 帆北修一, 夏越祥次
    • Organizer
      第83回日本胃癌学会総会
    • Place of Presentation
      三沢市
    • Year and Date
      2011-03-04
    • Related Report
      2012 Final Research Report
  • [Presentation] センチネルリンパ節生検を用いた幽門保存胃切除術の経験2010

    • Author(s)
      上之園芳一, その他
    • Organizer
      第40回胃外科・術後障害研究会
    • Place of Presentation
      東京都新宿区
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Extended Indication for ESD with Sentinel Node Biopsy in Gastric Cancer2010

    • Author(s)
      上之園芳一, その他
    • Organizer
      The 7th International Sentinel Node Society Meeting
    • Place of Presentation
      Yokohama Japan
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上部消化器癌におけるSentinel Node Navigation Surgeryの現状と将来展望2010

    • Author(s)
      上之園芳一, その他
    • Organizer
      第12回Sentinel Node Navigation Surgery研究会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sentinel Node Navigation Surgery for upper Gl cancer2010

    • Author(s)
      上之園芳一, その他
    • Organizer
      The 12th Scientific Conference of Korean Laparoendoscopic Gastrointestinal Surgery Study Group Korean Gastric Cancer Association
    • Place of Presentation
      SeoulKorea
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 未分化型早期胃癌におけるESD適応拡大へのSentinel Node理論の応用2010

    • Author(s)
      上之園芳一, その他
    • Organizer
      第8回日本消化器外科学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌における CellSearch system を用いた血中循環癌細胞の検出2010

    • Author(s)
      上之園芳一, 有上貴明, 平田宗嗣, 小園 勉, 萩原貴彦, 柳田茂寛, 石神純也, 帆北修一, 愛甲 孝, 夏越祥次
    • Organizer
      第65回日本消化器外科学会定期学術総会
    • Place of Presentation
      下関市
    • Year and Date
      2010-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃癌におけるCellSearch systemを用いた血中循環癌細胞の検出2010

    • Author(s)
      上之園芳一, その他
    • Organizer
      第65回日本消化器外科学会定期学術総会
    • Place of Presentation
      下関市
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃癌患者における血中循環癌細胞の検出の意義2010

    • Author(s)
      上之園芳一, 有上貴明, 平田宗嗣, 萩原貴彦, 柳田茂寛, 有馬豪男, 小園 勉, 石神純也, 帆北修一, 愛甲 孝, 夏越祥次
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-04-08
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 胃癌におけるCTCsの存在意義とHER2発現解析による臨床応用への展望

    • Author(s)
      上之園芳一
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 3. Clinical significance of circulating tumor cells in blood from patients with gastric cancer

    • Author(s)
      Yoshikazu Uenosono
    • Organizer
      5th World Circulating Tumor Cell Summit, Asia
    • Place of Presentation
      Singapore
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 胃癌における血中循環癌細胞検出およびHer2発現の検討

    • Author(s)
      上之園芳一
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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