Investigation of tumor heterogeneity through analyses of local distribution of tissue metabolites using imaging mass spectrometry
| Project/Area Number |
22501034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | がんの個性診断 / 腫瘍組織 / 顕微質量分析 / 代謝物 / 不均一性 / がん / 代謝適応 / in vivoモデル / 臨床検体 |
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| Research Abstract |
We successfully detected local distribution of tissue metabolites by imaging mass spectrometry to reveal the tumor heterogeneity formed by metabolic adaptation. These results provide insights into the metabolomic aspects of tumor biology, aiding in the de
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Overexpression of the miR-34 family suppresses invasive growth of malignant melanoma with the wild-type p53 gene.2012
Author(s)
Yamazaki H, Chijiwa T, Inoue Y, Abe Y, Suemizu H, Kawai K, Wakui M, Furukawa D, Mukai M, Kuwao S, Saegusa M, Nakamura M.
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Journal Title
Exp Ther Med.
Volume: 3 (5)
Pages: 793-796
Related Report
Peer Reviewed
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[Journal Article] Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice2011
Author(s)
KuboA, Ohmura M,Wakui M, Takeshita K, Harad T, Kajihara S, Ogawa K, SuemizuH, Nakamura M, Setou M, Suematsu M.
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Journal Title
Anal. Bioanal. Chem.
Volume: 400 (7)
Pages: 1895-1904
Related Report
Peer Reviewed
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[Journal Article] The cytostatic effects of lovastatin on ACC-MESO-1 cells.2011
Author(s)
Asakura K, Izumi Y, Yamamoto M, Yamauchi Y, Kawai K, Serizawa A, Mizushima, T, Ohmura M, Kawamura M, Wakui M, Adachi T, Nakamura M, Suematsu M, Nomori H.
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Journal Title
J. Surg. Res.
Volume: 170 (2)
Related Report
Peer Reviewed
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[Journal Article] The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.2011
Author(s)
Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnaoi M, Wakui M, Ito M,Suematsu M, Peltz G, Nakamura M, Suemizu1 M.
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 405 (3)
Pages: 405-410
Related Report
Peer Reviewed
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[Journal Article] The influence of donor age on liver regeneration and hepatic progenitor cell populations.2011
Author(s)
Ono Y, Kawachi S, Hayashida T, Wakui M, Tanabe M, Itano O, Obara H, Shinoda M, Hibi T, Oshima G, Tani N, Mihara K, Kitagawa Y.
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Journal Title
Surgery.
Volume: 150 (2)
Pages: 154-161
Related Report
Peer Reviewed
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[Journal Article] Reduced CD73 expression and its association with altered purine nucleotide metabolism in colorectal cancer cells robustly causing liver metastases.2010
Author(s)
Matsuyama M, Wakui M, Monnai M, Mizushima T, Nishime C, Kawai K, Ohmura M, Suemizu H, Hishiki T, Suematsu M, Murata M, Chijiwa T, Furukawa D, OgoshiK, Makuuchi H, Nakamura M.
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Journal Title
Oncol. Lett.
Volume: 1
Pages: 431-436
Related Report
Peer Reviewed
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[Presentation] New software for imaging mass spectrometry data.2012
Author(s)
MatsuuraM、Ushijima M, Yuba-KuboA,WakuiM, Hosaka K, Hayasaka T, Masaki N, Goto-Inoue N, Miyata S, Yao I, Setou M, Ogawa K, Kajihara S.
Organizer
Presented at the 103rd Annual Meeting of American Association for Cancer Research
Place of Presentation
Chicago Illinoi, USA
Related Report
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[Presentation] Software for peak picking using common peak method for imaging mass spectrometry data.2011
Author(s)
Ushijima M, Kajihara S, Hosaka K, Hayasaka T, Goto-Inoue N, Yuba-Kubo A, Wakui M, Yao I, Setou M, Matsuura M
Organizer
the 59th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics
Place of Presentation
Denver Colorado, USA
Related Report
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[Presentation] Reduced ecto-5'-nucleotidase CD73 expression and altered purine nucleotide metabolism in colorectal cancer cells robustly causing liver metastases.2010
Author(s)
Matsuyama M, Wakui M, Monnai M, Mizushima T, Nishime C, Kawai K, OhmuraM, Suemizu H, Hishiki T, Suematsu M, Murata M, Chijiwa T, Furukawa D^2, OgoshiK, Makuuchi H, Nakamura M.
Organizer
the 101st Annual Meeting of American Association for Cancer Research
Place of Presentation
Washington, DC, USA
Related Report
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[Presentation] Adaptation of cancer cells to hypoxic environments for tumor progression.2010
Author(s)
Mizushima T, Kawai K, Nishime C, OhmuraM, Hayakawa E, Matsuyama M, Asakura K, Izumi Y, Suemizu H, Ohnishi Y, NakamuraM, Suematsu M, Wakui M.
Organizer
the 101st Annual Meeting of American Association for Cancer Research
Place of Presentation
Washington, DC, USA
Related Report
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[Presentation] Metabolomic profiling of the liver bearing human colon cancer metastasis in superimmunodeficient NOG mice.2010
Author(s)
Ohmura M, Handa K, Nishime C, Mizushima T, Kawai K, Hishiki T, Yamamoto T, Wakui M, Suemizu H, Namakura M, Kiyagawa Y, Suematsu M.
Organizer
Experimental Biology 2010
Place of Presentation
Anaheim, California, USA
Related Report
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[Presentation] A novel method to display the structural features included in the mass spectrometryimaging dataset.2010
Author(s)
Yasuno M, Kajihara S, Morinaga H, Ikegami M, Ogawa K, Kubo A, Wakui M, Hayasaka T, Setou M.
Organizer
the 58th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics
Place of Presentation
Salt Lake City, Utah, USA
Related Report
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[Presentation] Microscopic imaging mass spectrometry on hepatic micrometastasis of human colon cancer xenografts in superimmunodeficient NOG mice2010
Author(s)
Kubo A, Ohmura M, Wakui M, Kawai K, Nishime C, Hishiki T, Murata M, Ogawa K, Setou M, Suematsu M
Organizer
the 58th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics
Place of Presentation
Salt Lake City, Utah, USA
Related Report
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[Presentation] Transportal metastasis of human colon cancer impairs gluconeogenesis in superimmunodeficient NOG mice.2010
Author(s)
Ohmura M, Kubo A, Handa K, Nishime C, Mizushima T, Kawai K, Hishiki T, Yamamoto T, Wakui M, Suemizu H, Nakamura M, Kitagawa Y, Setou M, Suematsu M.
Organizer
The 9th World Congress for Microcirculation
Place of Presentation
Paris, France
Related Report
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