Clinical Application of DNA Methylation Analysis Using Gastric Washes as an ESD Treatment Marker for Early Gastric Cancer
Project/Area Number |
22501038
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Tumor diagnosis
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Research Institution | St. Marianna University School of Medicine |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 胃がん / メチル化 / 胃洗浄廃液 / 胃癌 / DNAメチル化 / EMR / ESD / Sox17 / MINT25 |
Research Abstract |
We have developed a new methodology for gastric cancer detection by DNA methylation in gastric washes. It is easy and useful for early detection of recurrence after endoscopic treatment in GCa patients. We now have on going prospective studies.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Hypermethylation of Sox17 gene is useful as a molecular diagnostic application in early gastric cancer.2012
Author(s)
Watanabe Y, Oishi Y, Yoshida Y, Sato Y, Hiraishi T, Oikawa R, Maehata T, Suzuki H, Toyota M, Niwa H, Suzuki M, Itoh F.
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Journal Title
Tumour Biol
Volume: 33(2)
Pages: 383-93
Related Report
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[Journal Article] Characterization of DNA hypermethylation in two cases of peritoneal mesothelioma.2012
Author(s)
Watanabe Y, Hama R, Shinada K, Yamada Y, Ogata Y, Yoshida Y, TamuraT, Hiraishi T, Oikawa R, Sakurai J, Maehata T, Koizumi H, Itoh F.
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Journal Title
Tumor Biol.
Volume: 33(6)
Pages: 2031-40
Related Report
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[Journal Article] Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.2011
Author(s)
Watanabe Y, Castoro RJ, Kim HS, North B, Oikawa R, Hiraishi T, Ahmed SS, Chung W, Cho MY, Toyota M, Itoh F, Estecio MR, Shen L, Jelinek J, Issa JP.
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Journal Title
Related Report
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[Journal Article] Gastric wash-based molecular testing for antibiotic resistance in helicobacter pylori.2011
Author(s)
Baba S, Oishi Y, Watanabe Y, Oikawa R, Morita R, Yoshida Y, Hiraishi T, Maehata T, Nagase Y, Fukuda Y, Nakazawa M, Ishigouoka S, Hattori N, Suzuki H, Toyota M, Niwa H, Suzuki M, Itoh F.
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Journal Title
Digestion
Volume: 84
Pages: 299-305
Related Report
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[Journal Article] DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis.2011
Author(s)
Watanabe Y, Konishi K, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estecio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP.
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Journal Title
Related Report
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