| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Research Abstract |
The purpose of the present study was to identify histological surrogate predictive markers of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC). 92 core needle biopsy (CNB) specimens obtained before NAC were available. As controls, CNB specimens from 42 tumors of the hormone receptor-negative and HER2-positive (HR-/HER2+) subtype and 46 tumors of the hormone receptor-positive and HER2-negative (HR+/HER2-) subtype were also included. Histopathological examination including tumor-infiltrating lymphocytes (TIL) and tumor cell apoptosis, and immunohistochemical studies for basal markers were performed, In TNBC, the pCR rate of tumors showing a high TIL score was 37%, and significantly higher than that of the tumors showing a low TIL score (16%, p = 0.05). In a total of 180 breast cancers, the pCR rate of the tumors showing a high TIL score (34%) was significantly higher than that of the tumors showing a low TIL score (10%) (p = 0.0001). In TNBC, the pCR rate of tumors showing an apoptosis score 2 was 48%, and tended to be higher than that of the tumors showing an apoptosis score of 0 or 1 (23%, p = 0.10). In a total of 180 breast cancers, the pCR rate of the tumors showing an apoptosis score 2 (35%) was significantly higher than that of the tumors showing an apoptosis score of 0 or 1 (19%) (p = 0.04). The basal-like marker expression or p53 nuclear immunoreaction was not correlated with pCR in TNBC. Histologically, medullary/atypical medullary and apocrine types showed higher pCR rates (39% and 40%), while central acellular and metaplastic types showed lower pCR rates (21% and 17%). The degree of TIL correlated with immune response appear to play a substantial role in the response to NAC in TNBC.
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