Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Research Abstract |
Stem cell factor/c-kit and insulin-like growth factor-I(IGF-I)/IGF-I receptor were detected in small cell lung cancer specimens. In small cell lung cancer cell line, H209 cells, both stem cell factor and IGF-I induced amrubicin resistance. A Src inhibitor, dasatinib, restored the sensitivity to amrubicinin stem cell factor-treated H209 cells. However, dasatinib did not affected IGF-I-induced amrubicinresistance.
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