Development of a biomarker for small intestinal mucosal injury following chemotherapy for gastric cancer and establishment of new method to prevent gastrointestinal adverse event
| Project/Area Number |
22501045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yoshiaki 久留米大学, 医学部, 准教授 (50188348)
NAMIKAWA Tsutomu 高知大学, 教育研究部医療学系, 講師 (50363289)
KITAGAWA Hiroyuki 高知大学, 教育研究部医療学系, 助教 (10403883)
FUKUDOME Ian 高知大学, 医学部附属病院, 医員 (00587545)
OGATA Hiromi 高知大学, 教育研究部医療学系, 助教 (30341366)
FUJITA Mamoru 中村学園大学, 栄養科学部, 教授 (60037471)
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| Co-Investigator(Renkei-kenkyūsha) |
BABA Ryouko 産業医科大学, 医学部, 講師 (90271436)
KUMAGAI Nana 中村学園大学, 栄養科学部, 助手 (70552983)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 化学療法 / DAO活性 |
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| Research Abstract |
To clarify the gastro-intestinal adverse event (mainly diarrhea) and morphological change of the small intestine after chemotherapy, we investigate the correlation between DAO activity and morphological change of small intestine by light microscopy, immuno-histochemistry (for PCNA and Ki67) and scanning electron microscopy. We also investigated that soluble dietary fiber could prevent the injury for small intestine. The conclusions are 1) DAO activity can indicate the small intestine injury after chemotherapy, and 2) soluble dietary fiber may have an effect to improve the small intestine injury.
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Report
(4 results)
Research Products
(7 results)
