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Analysis of cooperative functions of transporters andvesicle transport system in efflux of anticancer agents

Research Project

Project/Area Number 22501047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical oncology
Research InstitutionKagoshima University

Principal Investigator

FURUKAWA Tatsuhiko  鹿児島大学, 大学院・医歯学総合研究科, 教授 (40219100)

Co-Investigator(Kenkyū-buntansha) IKEDA Ryuji  鹿児島大学, 医学部・歯学部附属病院, 准教授 (50398278)
KANEKURA Takuro  鹿児島大学, 大学院・医歯学総合研究科, 教授 (70177509)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsATP7A / Rab 蛋白質 / 抗癌剤耐性 / 薬剤輸送体 / 小胞輸送 / 抗がん剤耐性 / ATP7A / Gタンパク質 / Rabタンパク質 / ATP7B / Rab蛋白質
Research Abstract

We isolated human Rab27a and Rab27b cDNA. Human Rab27a, mousedominant negative mouse Rab2 or dominant negative mouse Rab9 expressing cells were established from ATP7A over expression cells respectively. We found the cells expressing ATP7B whose 6th metal binding domain was mutated were as sensitive as the parental cells to CDDP.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (123 results)

All 2013 2012 2011 2010

All Journal Article (41 results) (of which Peer Reviewed: 41 results) Presentation (80 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells.2013

    • Author(s)
      Tajitsu Y, Ikeda R, Nishizawa Y, Mataki H, Che XF, Sumizawa T, Nitta M, YamaguchT, Yamamoto M, Tabata S, Akiyama S, Yamada K, Furukawa T, Takeda Y
    • Journal Title

      Int J of Mol Med

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] VEGF expression is augmented by hypoxia-induced PGIS in human fibroblasts.2013

    • Author(s)
      Wang J, Ikeda R, Che XF, Ooyama A, Yamamoto M, Furukawa T, Hasui K, Zheng Cl, Tajitsu Y, Oka T, Tabata S, Nishizawa Y, Eizuru Y, Akiyama S
    • Journal Title

      Int J Onc

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for the regulation of hypoxia-inducible factor-1α levels by 2-deoxy-D-ribose.2013

    • Author(s)
      Ikeda R, Tabata S, Tajitsu Y, Nishizawa Y, Minami K, Furukawa T, Yamamoto M, Shinsato Y, Akiyama S, Yamada K , Takeda Y
    • Journal Title

      Onc Rep

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ceramide aminoethylphosphonate from jumbo flying squid Dosidicus gigas attenuates the toxicity of cyanotoxin microcystin-LR.2013

    • Author(s)
      Komatsu M, Ichiyama N, Kurimoto T, Takumi S, Shiozaki K, Sugiyama Y, Furukawa T, Ando S, Itonori S, Saito H
    • Journal Title

      Fish Sci

      Volume: 79 Pages: 313-320

    • NAID

      10031138669

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Snail modulates cell metabolism in MDCK cells.2013

    • Author(s)
      Haraguchi M, Indo HP, Iwasaki Y, Iwashita Y, Fukushige T, Majima HJ, Izumo K, Horiuchi M, Kanekura T, Furukawa T, Ozawa M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432(4) Pages: 618-625

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly- (4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells.2013

    • Author(s)
      Kamimura M, Furukawa T, Akiyama S, Nagasaki Y
    • Journal Title

      Biomater. Sci

      Volume: 1 Pages: 361-367

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blastic plasmacytoid dendritic cell neoplasm in a human T-cell lymphotropic virus type I (HTLV-1) carrier: a coincidental association?2013

    • Author(s)
      Uchida Y, Kawai K, Kubo H, Takeda K, Shimokawa M, Yoshii N, Kanekura T
    • Journal Title

      Eur J Dermatol

      Volume: 23(2) Pages: 250-1

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The etiologic role of human papillomavirus in penile cancers: a study in Vietnam.2013

    • Author(s)
      Do HT, Koriyama C, Khan NA, Higashi M, Kato T, Le NT, Matsushita S, Kanekura T, Akiba S.
    • Journal Title

      Br J Cancer.

      Volume: 108(1) Pages: 229-33

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-22013

    • Author(s)
      Shimokawa M, Haraguchi M, Kobayashi W, Higashi Y, Matsushita S, Kawai K, Kanekura T, Ozawa M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 430(3) Pages: 1078-82

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly- (4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells2013

    • Author(s)
      Masao Kamimura
    • Journal Title

      Biomater. Sci.

      Volume: 1 Pages: 361-367

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Snail modulates cell metabolism in MDCK cells.2013

    • Author(s)
      Haraguchi M
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 432 Issue: 4 Pages: 618-625

    • DOI

      10.1016/j.bbrc.2013.02.035

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ceramide aminoethylphosphonate from jumbo flying squid Dosidicus gigas attenuates the toxicity of cyanotoxin microcystin-LR.2013

    • Author(s)
      Masaharu Komatsu
    • Journal Title

      Fishery Science

      Volume: 79 Pages: 313-320

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for the regulation of hypoxia-inducible factor-1α levels by 2-deoxy-D-ribose.2013

    • Author(s)
      Ryuji Ikeda
    • Journal Title

      Oncology Report

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VEGF expression is augmented by hypoxia‑induced PGIS in human fibroblasts2013

    • Author(s)
      Jia Wang
    • Journal Title

      International J. Oncology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells.2013

    • Author(s)
      Yusuke Tajitsu
    • Journal Title

      International J of Molecular Medicine

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT32012

    • Author(s)
      Yue H, Tanaka K, Furukawa T, Karnik SS, Li W
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1823 (8) Pages: 1316-1323

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells.2012

    • Author(s)
      Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S, Akiyama S
    • Journal Title

      Oncology Reports

      Volume: 28(3) Pages: 895-902

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD147- targeting siRNA inhibits cell-matrix adhesion of human malignant melanoma cells by phosphorylating focal adhesion kinase2012

    • Author(s)
      Nishibaba R, Higashi Y, Su J, Furukawa T, Kawai K, Kanekura T
    • Journal Title

      J Dermatol

      Volume: 39(1) Pages: 63-67

    • NAID

      10031184828

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53R2 is a prognostic factor of melanoma and regulates proliferation and chemosensitivity of melanoma cells.2012

    • Author(s)
      Matsushita S, Ikeda R, Fukushige T, Tajitsu Y, Gunshin K, Okumura H, Ushiyama M, Akiyama S, Kawai K, Takeda Y, Yamada K, Kanekura T
    • Journal Title

      J Dermatol Sci

      Volume: 68(1) Pages: 19-24

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunoglobulin G4-positive multi-organ lymphoproliferative syndrome with antiphospholipid antibody syndrome2012

    • Author(s)
      Kawakami N, Kawai K, Baba N, Ohshima K, Kanekura T
    • Journal Title

      J Dermatol

      Volume: 39(7) Pages: 636-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a newly-developed immunochromatography strip test for diagnosing dermatophytosis.2012

    • Author(s)
      Higashi Y, Miyoshi H, Takeda K, Saruwatari H, Kubo H, Sakaguchi I, Iwata M, Uchida Y, Tada K, Miyamoto M, Wakamoto H, Takasaki S, Ishida H, Noriki S, Kanekura T
    • Journal Title

      Int J Dermatol

      Volume: 51(4) Pages: 406-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indication for random skin biopsy for the diagnosis of intravascular large B cell lymphoma.2012

    • Author(s)
      Higashi Y, Kawai K, Yonekura K, Takeda K, Kanzaki T, Utsunomiya A, Kanekura T
    • Journal Title

      Dermatology

      Volume: 224(1) Pages: 46-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MK615, a Prunus mume Steb. Et Zucc ('Ume') extract, attenuates the growth of A375 melanoma cells by inhibiting the ERK1/2-Id-1 pathway.2012

    • Author(s)
      Tada K, Kawahara K, Matsushita S, Hashiguchi T, Maruyama I, Kanekura T
    • Journal Title

      Phytother Res

      Volume: 26(6) Pages: 833-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease2012

    • Author(s)
      Yoshifuku A, Oyama K, Ibusuki A, Kawasaki M, Sakanoue M, Matsushita S, Kawai K, Kawahara K, Maruyama I, Kanekura T
    • Journal Title

      Clin Exp Dermatol

      Volume: 37(3) Pages: 241-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akiyama S, Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells2012

    • Author(s)
      Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 895-902

    • DOI

      10.3892/or.2012.1887

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT32012

    • Author(s)
      Yue H
    • Journal Title

      Biochim Biophys Acta

      Volume: 1823 Issue: 8 Pages: 1316-1323

    • DOI

      10.1016/j.bbamcr.2012.05.025

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD147-targeting siRNA inhibits cell-matrix adhesion of human malignant melanoma cells by phosphrylating focal adhesion kinase2012

    • Author(s)
      Nishibaba R
    • Journal Title

      J Dermatol

      Volume: 39 Issue: 1 Pages: 63-67

    • DOI

      10.1111/j.1346-8138.2011.01304.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8expression in human cancer cells2012

    • Author(s)
      Tabata S
    • Journal Title

      Oncology Reports

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic eunicellin-type diterpenes from the soft coral liphyton viscudium2011

    • Author(s)
      Iwagawa T, Kusatsu T, Tsuha K, Hamada T, Okamura H, Furukawa T, Akiyama S, Doe M, Morimoto Y, Iwase F, Takemurae K
    • Journal Title

      Heterocycles

      Volume: 83(9) Pages: 2149-2155

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance2011

    • Author(s)
      White Y, Hamada T, Yoshimitsu M, Nakashima M, Hachiman M, Kozako T, Matsushita K, Uozumi K, Suzuki S, Kofune H, Furukawa T, Arima N
    • Journal Title

      Anticancer Res

      Volume: 31(12) Pages: 4251-4257

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retinoic acids exhibit anti-fibrotic activity through the inhibition of 5-lipoxygenase expression in scleroderma fibroblasts2011

    • Author(s)
      Xiao R, Yoshida N, Higashi Y, Lu QJ, Fukushige T, Kanzaki T, Kanekura T
    • Journal Title

      J Dermatol

      Volume: 38(4) Pages: 345-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role for E-cadherin as an inhibitory receptor on epidermal gammadelta T cells2011

    • Author(s)
      Uchida Y, Kawai K, Ibusuki A, Kanekura T
    • Journal Title

      J Immunol

      Volume: 186(12) Pages: 6945-54

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance2011

    • Author(s)
      White Y
    • Journal Title

      Anticancer Res

      Volume: 31 Pages: 4251-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic Isomalabaricane Derivatives and a Monocyclic Triterpene Glycoside from the Sponge Rhabdastrella globostellata2010

    • Author(s)
      Hirashima M, Tsuda K, Hamada T, Okamura H, Furukawa T, Akiyama S, Tajitsu Y, Ikeda R, Komatsu M, Doe M, Morimoto Y, Shiro M, van Soest RW, Takemura K, Iwagawa T
    • Journal Title

      J. Nat. Prod.

      Volume: 73(9) Pages: 1512-1518

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 Plays an Important Role in Cell Fate Determination after Exposure to Microcystin-LR2010

    • Author(s)
      Takumi S, Komatsu M, Furukawa T, Ikeda R, Sumizawa T, Akenaga H, Maeda Y, Aoyama K, Arizono K, Ando S, Takeuchi T
    • Journal Title

      Environmental Health Perspectives

      Volume: 118(9) Pages: 1292-1298

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells2010

    • Author(s)
      Matsushita S, Ikeda R, Nishizawa Y, Che XF, Furukawa T, Miyadera K, Tabata S, Ushiyama M, Tajitsu Y, Yamamoto M, Takeda Y, Minami K, Mataki H, Kanzaki T, Yamada K, Kanekura T, Akiyama S
    • Journal Title

      Int J Oncol

      Volume: 36(5) Pages: 1193-200

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Major vault protein forms complexes with hypoxia-inducible factor (HIF)-1α and reduces HIF-1α level in ACHN human renal adenocarcinoma cells2010

    • Author(s)
      Iwashita K-I, Ikeda R, Takeda Y, Sumizawa T, Furukawa T, Yamaguchi T, Akiyama S, Yamada K
    • Journal Title

      Cancer Science

      Volume: 100(4) Pages: 920-926

    • NAID

      10026590870

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB.2010

    • Author(s)
      Mera K, Kawahara K, Tada K, Kawai K, Hashiguchi T, Maruyama I, Kanekura T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 25;397(2) Pages: 350-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Major vault protein forms complexes with hypoxia-inducible factor (HIF)-1α and reduces HIF-1α level in ACHN human renal adenocarcinoma cells2010

    • Author(s)
      Iwashita K-I
    • Journal Title

      Cancer Science

      Volume: 100 Pages: 920-926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells2010

    • Author(s)
      Matsushita S
    • Journal Title

      Int J Oncol

      Volume: 36 Pages: 1193-1200

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 Plays an Important Role in Cell Fate Determination after Exposure to Microcystin-LR2010

    • Author(s)
      Takumi S
    • Journal Title

      Environmental Health Perspectives

      Volume: 118 Pages: 1292-1298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高浸透圧で誘導されるヴォールトの発現亢進機序と高浸透圧耐性化機構2013

    • Author(s)
      池田龍二、田實裕介、西澤由紀彦、古川龍彦、秋山伸一、山田勝士、武田泰生
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 高浸透圧によって誘導される Major vault protein(MVP)の発現亢進機序2013

    • Author(s)
      田實裕介、池田龍二、西澤由紀彦、山口辰哉、山本雅達、田畑 祥、秋山伸一、山田勝士、古川龍彦、武田泰生
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 5-AZa-2-deoxy cytidine (5-Aza-CdR) enhance the sensitivity of 5-fluorouracil (5-FU) in KB3-1 human carcinoma cells2013

    • Author(s)
      Nishizawa Y, Ikeda R, Tabata S, Tajitsu Y, Kawahara K, Yamamoto M, Shinsato Y, Minami K, Akiyama S, Furukawa T, Takeda Y
    • Organizer
      19th International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      Kagoshima
    • Related Report
      2012 Final Research Report
  • [Presentation] The attenuation of MLH1 expression confers to acquisition of temozolomide resistance of glioblastoma cells and recurrence of glioblastomas in the course administration of temozolomide2013

    • Author(s)
      Shinsato Y, Furukawa T, Yunoue S, Yonezawa H, Minami K, Nishizawa Y, Ikeda R, Yamamoto M, Hirano H, Arita K
    • Organizer
      19th International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      Kagoshima
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of CNT1 and RRM1 are involved in gemcitabine resistant of pancreatic cancer cells2013

    • Author(s)
      Minami K, Yamamoto M, Ikeda R, Komatsu M, Kawahara K, Shinsato Y, Tabata S, Yamada K, Akiyama S, Takeda Y, Furukawa T
    • Organizer
      19th International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      Kagoshima
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of CNT1 and RPM1 are involved in gemcitabine resistant of pancreatic cancer cells.2013

    • Author(s)
      Kentaro Minami
    • Organizer
      9th International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] The attenuation of MLH1 expression confers to acquisition of temozolomide resistance of glioblastoma cells and recurrence of glioblastomas in the course administration of temozolomide2013

    • Author(s)
      Yoshinari Shinsato
    • Organizer
      9th International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 5-AZa-2-deoxycytidine (5-Aza-CdR)enhance the sensitivity of 5-fluorouracil(5-FU)in KB3-1 human carcinoma cells2013

    • Author(s)
      Yukihiko Nishizawa
    • Organizer
      9th International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高浸透圧によって誘導されるMajor vault protein (MVP)の発現亢進機序2013

    • Author(s)
      田實裕介
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高浸透圧で誘導されるヴォールトの発現亢進機序と高浸透圧耐性化機構2013

    • Author(s)
      池田龍二
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム 2S13 生体遷移金属のパラダイムシフト:生体内シグナル分子としての機能 Abcb10は Heme 合成に必須であって、その欠損マウスはヒト Erythropoietic protoporyphyriaと類似の病態を示す2012

    • Author(s)
      山本雅達、有村 博、福重智子、河原康一、中川昌之、金蔵拓郎、古川龍彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 発がんプロモーターであるマイクロシスチン LR はアノイキス抵抗性を誘導する2012

    • Author(s)
      高野博之、内匠正太、塩崎一弘、杉山靖正、古川龍彦、小松正治
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ワークショップ 1W7III-3 構造に基づいた ABC 蛋白質の分子メカニズムと疾患:ミトコンドリア ABC トランスポーターの Abcb10の機能と病態2012

    • Author(s)
      古川龍彦、山本雅達、福重智子、金蔵拓郎
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 鼻咽頭リンパ腫のマクロファージと樹状細胞で特徴付けられる癌微小環境2012

    • Author(s)
      蓮井和久、永井 拓、古川龍彦、金蔵拓郎、河野嘉文、榮鶴義人、青笹克也、松山隆美
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] ゲフィチニブとエルロチブが H23 細胞のアポトーシスと c-MYC発現に与える影響2012

    • Author(s)
      末永光宏、古川龍彦
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト癌細胞の生存におけるチミジン異化作用の役割2012

    • Author(s)
      田畑 祥、池田龍二、山本雅達、古川龍彦、倉本卓哉、後東久嗣、植淵昌毅、西岡安彦、曽根三郎、秋山伸一
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] DEC2 によるgemcitabine 耐性の抑制2012

    • Author(s)
      古川龍彦、南 謙太朗、西澤由紀彦、新里能成、山本雅達、河原康一、小松正治、田畑 祥、秋山伸一、池田龍二
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Gemcitabine 耐性膵癌細胞での CNT1 と RRM1 の役割2012

    • Author(s)
      南 謙太朗、山本雅達、河原康一、小松正治、池田龍二、田畑 祥、秋山伸一、山田勝士、武田泰生、古川龍彦
    • Organizer
      第6回トランスポーター研究会九州部会
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 5-fluorouracil(5-FU)と5-aza-2-deoxycytidine(5-Aza)の組合せによる抗腫瘍効果増強の機序解明2012

    • Author(s)
      西澤由紀彦、池田龍二、田畑 祥、田實裕介、牛山美奈、山本雅達、山田勝士、古川龍彦、武田泰生
    • Organizer
      第6回 トランスポーター研究会九州部会
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 5-aza-2-deoxycytidine(5-Aza)による5-flurouracil(5-FU)の抗腫瘍効果増強作用の機序解明2012

    • Author(s)
      西澤由紀彦、池田龍二、田畑 祥、田實裕介、牛山美奈、山本雅達、山田勝士、古川龍彦、武田泰生
    • Organizer
      医療薬学フォーラム 2012 第20回クリニカルファーマシーシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Gemcitabine 耐性膵癌細胞での CNT1 と RRM1 の関わり2012

    • Author(s)
      南謙太朗、山本雅達、河原康一、小松正治、池田龍二、田畑 祥、秋山伸一、山田勝士、武田泰生、古川龍彦
    • Organizer
      医療薬学フォーラム 2012 第20回クリニカルファーマシーシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] DEC2 によるgemcitabine 耐性膵癌細胞の耐性抑制2012

    • Author(s)
      南 謙太朗、山本雅達、小松正治、池田龍二、新里能成、田畑 祥、秋山伸一、古川龍彦
    • Organizer
      第16回学術集会日本がん分子標的治療学会
    • Place of Presentation
      北九州市
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] MLH1 発現低下とヒト glioma 細胞の TMZ 耐性獲得との関連2012

    • Author(s)
      新里能成、南 謙太朗、田畑 祥、山本雅達、池田龍二、秋山伸一、古川龍彦
    • Organizer
      第16回学術集会日本がん分子標的治療学会
    • Place of Presentation
      北九州市
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト癌細胞の ROS産生および生存におけるチミジン異化作用の役割2012

    • Author(s)
      田畑 祥、池田龍二、山本雅達、古川龍彦、倉本卓哉、後東久嗣、植淵昌毅、西岡安彦、曽根三郎、秋山伸一
    • Organizer
      第16回学術集会日本がん分子標的治療学会
    • Place of Presentation
      北九州市
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Abcb10は Heme 合成に必須であって、その欠損マウスはヒト Erythropoietic protoporphyria と類似の病態を示す2012

    • Author(s)
      山本雅達、有村博史、福重智子、河原康一、中川昌之、金蔵拓郎、古川龍彦
    • Organizer
      第7回トランスポーター研究会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] CNT1 と RPM1の発現変化が Gemcitabine 耐性膵臓癌細胞の耐性へ関与している2012

    • Author(s)
      古川龍彦、南 謙太朗、西澤由紀彦、池田龍二、山本雅達、武田泰生
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Abcb10はHeme合成に必須であって、その欠損マウスはヒトErythropoietic protoporphyria と類似の病態を示す2012

    • Author(s)
      山本雅達
    • Organizer
      第7回トランスポーター研究会年会
    • Place of Presentation
      京都府京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト癌細胞のROS産生および生存におけるチミジン異化作用の役割2012

    • Author(s)
      田畑 祥
    • Organizer
      日本がん分子標的治療学会 第16回学術集会
    • Place of Presentation
      福岡県北九州市
    • Related Report
      2012 Annual Research Report
  • [Presentation] MLH1発現低下とヒトglioma細胞のTMZ耐性獲得との関連2012

    • Author(s)
      新里能成
    • Organizer
      日本がん分子標的治療学会 第16回学術集会
    • Place of Presentation
      福岡県北九州市
    • Related Report
      2012 Annual Research Report
  • [Presentation] DEC2によるgemcitabine耐性膵癌細胞の耐性抑制2012

    • Author(s)
      南 謙太朗
    • Organizer
      日本がん分子標的治療学会 第16回学術集会
    • Place of Presentation
      福岡県北九州市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 5-fluorouracil(5-FU)と5-aza-2-deoxytidine(5-Aza)の組合せによる抗腫瘍効果増強の機序解明2012

    • Author(s)
      西澤由紀彦
    • Organizer
      第6回 トランスポーター研究会九州部会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gemcitabine耐性膵癌細胞でのCNT1とRPM1の役割2012

    • Author(s)
      南 謙太朗
    • Organizer
      第6回 トランスポーター研究会九州部会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] DEC2によるgemcitabine耐性の抑制2012

    • Author(s)
      古川龍彦
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト癌細胞の生存におけるチミジン異化作用の役割2012

    • Author(s)
      田畑 祥
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゲフィチニブとエルロチブがH23細胞のアポトーシスとc-MYC発現に与える影響2012

    • Author(s)
      末永光宏
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 鼻咽頭リンパ腫のマクロファージと樹状細胞で特徴付けられる癌微小環境2012

    • Author(s)
      蓮井和久
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      北海道札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリアABCトランスポーターのAbcb10の機能と病態2012

    • Author(s)
      古川龍彦
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発がんプロモーターであるマイクロシスチンLRはアノイキス抵抗性を誘導する2012

    • Author(s)
      高野博之
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Abcb10はHeme合成に必須であって、その欠損マウスはヒトErythropoietic protoporyphyriaと類似の病態を示す2012

    • Author(s)
      山本雅達
    • Organizer
      第85回日本生化学大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Abcb10は Heme 合成に必須であって、その欠損マウスはヒト Erythropoietic protoporphyria と類似の病態を示す2011

    • Author(s)
      山本雅達、有村博史、福重智子、河原康一、中川昌之、金蔵拓郎、古川龍彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] チミジンホスホリラーゼ発現腫瘍での5-flurouracil(5-FU)によるthrombospondin-1(TSP-1)発現誘導2011

    • Author(s)
      西澤由紀彦、池田龍二、田畑 祥、田實裕介、俣木博徳、古川龍彦、牛山美奈、山口辰哉、山本雅達、松下茂人、秋山伸一、山田勝士、武田泰生
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] CNT1 と RRM1 の発現変化がGemcitabine 耐性膵癌細胞 MGEM6 の耐性を担っている2011

    • Author(s)
      南謙太朗、山本雅達、小松正治、池田龍二、田畑 祥、秋山伸一、山田勝士、武田泰生、古川龍彦
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Gemcitabine 耐性膵臓癌細胞の CNT1と RRM1 の耐性機構への関与2011

    • Author(s)
      南 謙太朗、古川龍彦、山本雅達、西澤由紀彦、田畑祥、池田龍二、小松正治、秋山伸一
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌細胞での 5-FU 依存的early growth response protein-1 およびthrombospondin-1 発現亢進におけるthymidine phosphorylase の役割2011

    • Author(s)
      西澤由紀彦、池田龍二、松下茂人、田畑 祥、山本雅達、南 謙太郎、山口辰哉、秋山伸一、古川龍彦
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌細胞における無血清培地とゲフィチニブによる影響の違い2011

    • Author(s)
      末永光宏、古川龍彦
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2012 Final Research Report
  • [Presentation] チミジンホスホリラーゼによってチミジンから派生した糖の解糖系の移行2011

    • Author(s)
      田畑 祥、山本雅達、池田龍二、倉本卓哉、西岡安彦、曽根三郎、秋山伸一
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] チミジンホスホリラーゼによってチミジンから派生した糖の解糖系の移行2011

    • Author(s)
      田畑祥
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌細胞における無血清培地とゲフィチニブによる影響の違い2011

    • Author(s)
      末永光宏
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌細胞での5-FU依存的early growth response protein-1およびthrombospondin-1発現亢進におけるthymidine phosphorylaseの役割2011

    • Author(s)
      西澤由紀彦
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gemcitabine耐性膵臓癌細胞のCNT1とRRM1の耐性機構への関与2011

    • Author(s)
      南謙太朗
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前立腺癌で発現する PCA-1/ABH3 は新たな治療標的分子である2011

    • Author(s)
      古川龍彦、南 謙太朗、西澤由紀彦、山本雅達、青木俊二、辻川和丈
    • Organizer
      第5回 トランスポーター研究会九州部会
    • Place of Presentation
      宮崎
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Gemcitabine耐性での SLC28,29 と RRM1 の役割2011

    • Author(s)
      山本雅達、南 謙太朗、西澤由紀彦、池田龍二、小松正治、古川龍彦
    • Organizer
      第5回 トランスポーター研究会九州部会
    • Place of Presentation
      宮崎
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Gemcitabine耐性でのSLC28,29とRRM1の役割2011

    • Author(s)
      山本雅達
    • Organizer
      第5回トランスポーター研究会九州部会
    • Place of Presentation
      宮崎市
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前立腺癌で発現するPCA-1/ABH3は新たな治療標的分子である2011

    • Author(s)
      古川龍彦
    • Organizer
      第5回トランスポーター研究会九州部会
    • Place of Presentation
      宮崎市
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] CNT1と RRM1 の発現変化が Gemcitabine 耐性膵癌細胞株の耐性を担っている2011

    • Author(s)
      南 謙太朗、古川龍彦、山本雅達、池田龍二、小松正治、田畑祥、秋山伸一
    • Organizer
      第15回学術集会日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] CNT1とRRM1の発現変化がGemcitabine耐性膵癌細胞株の耐性を担っている2011

    • Author(s)
      南謙太朗
    • Organizer
      日本がん分子標的治療学会第15回学術集会
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] チミジンホスホリラーゼによってチミジンから派生した糖の解糖系への移行2011

    • Author(s)
      田畑 祥、山本雅達、池田龍二、古川龍彦、倉本卓哉、西岡安彦、曽根三郎、秋山伸一
    • Organizer
      第15回学術集会日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] チミジンホスホリラーゼによってチミジンから派生した糖の解糖系への移行日本がん分子標的治療学会第15回学術集会2011

    • Author(s)
      田畑祥
    • Organizer
      日本がん分子標的治療学会第15回学術集会
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] The difference between gefitinib and serum deprivation in cancer cells2011

    • Author(s)
      Mitsuhiro Suenaga
    • Organizer
      American Association for Cancer Research 102^<nd> Annual Meeting
    • Place of Presentation
      オーランド、アメリカ
    • Year and Date
      2011-04-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゼブラフィッシュ胚および OATP1B1 または OATP1B3 発現細胞を用いたマイクロシスチンの毒性評価2011

    • Author(s)
      嶋 佑介、塩崎一弘、杉山靖正、内匠正太、古川龍彦、小松正治
    • Organizer
      第5回 トランスポーター研究会九州部会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Final Research Report
  • [Presentation] The difference between gefitinib and serum deprivation in cancer cells2011

    • Author(s)
      Suenaga M, Yamamoto M, Furukawa T
    • Organizer
      American Association for Cancer Research 102nd Annual Meeting
    • Place of Presentation
      Orange County Convention Center, Orlando, Florida
    • Related Report
      2012 Final Research Report
  • [Presentation] CNT1 and RRM1 are involved in the Gemcitabine resistance mechanism in the pancreatic Gemcitabine resistant cells2010

    • Author(s)
      Furukawa T, Minami K, Yamamoto M, Ikeda R, Komatsu M
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] マングース Tert 遺伝子断片を導入したマングース線維芽細胞の細胞生物学的機能解析2010

    • Author(s)
      柳 久美子、花房宏昭、森田この美、宝来佐和子、山本雅達、古川龍彦、渡邉 泉、小倉 剛、要 匡
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] マングースTert遺伝子断片を導入したマングース線維芽細胞の細胞生物学的機能解析2010

    • Author(s)
      柳久美子
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] CNT1 and RRM1 are in volve in the Gemcitabine resistance mechanism in the pancreatic Gemcitabine resistant cells2010

    • Author(s)
      古川龍彦
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] MLH1 発現抑制とヒトglioma U251 細胞の TMZ 耐性獲得との関連2010

    • Author(s)
      新里能成、湯之上俊二、南 謙太郎、田畑 祥、車 暁芳、山本雅達、池田龍二、古川龍彦、秋山伸一
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Gemcitabine 耐性膵癌細胞MGEM6 の CNT1 と RRM1 の発現変化は耐性と関連している2010

    • Author(s)
      南 謙太郎、古川龍彦、山本雅達、池田龍二、小松正治、田畑 祥、車 暁芳、新里能成、秋山伸一
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] A431 細胞と A549細胞におけるゲフィチニブの c-MYC への効果2010

    • Author(s)
      末永光宏、古川龍彦
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] チミジンホスホリラーゼによる活性酵素の産生機構2010

    • Author(s)
      田畑 祥、山本雅達、池田龍二、古川龍彦、南 謙太郎、倉本卓哉、大塚健司、武田泰生、山田勝士、西岡安彦、曽根三郎、秋山伸一
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] チミジンホスホリラーゼによる活性酵素の産生機構2010

    • Author(s)
      田畑祥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] A431細胞とA549細胞におけるゲフィチニブのc-MYCへの効果2010

    • Author(s)
      末永光宏
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gemcitabine耐性膵癌細胞MGEM6のCNT1とRRM1の発現変化は耐性と関連している2010

    • Author(s)
      南謙太郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] MLH1発現抑制とヒトglioma U251細胞のTMZ耐性獲得との関連2010

    • Author(s)
      新里能成
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゲムシタビン耐性膵がん細胞での機構の解析2010

    • Author(s)
      古川龍彦、南 謙太郎、池田龍二、小松正治、山本雅達、田畑 祥、秋山伸一
    • Organizer
      第14回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] チミジンホスホリラーゼによる活性酵素の産生機構2010

    • Author(s)
      田畑 祥、山本雅達、池田龍二、古川龍彦、南 謙太郎、西岡安彦、曽根三郎、秋山伸一
    • Organizer
      第14回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Prostate cancer antigen-1 を分子標的とする前立腺癌治療創薬2010

    • Author(s)
      辻川和丈、青木俊二、古川龍彦
    • Organizer
      第14回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Prostate cancer antigen-1を分子標的とする前立腺癌治療創薬2010

    • Author(s)
      辻川和丈
    • Organizer
      第14回日本がん分子標的治療学会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] チミジンホスホリラーゼによる活性酸素の産生機構2010

    • Author(s)
      田畑祥
    • Organizer
      第14回日本がん分子標的治療学会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゲノシタビン耐性膵がん細胞での機構の解析2010

    • Author(s)
      古川龍彦
    • Organizer
      第14回日本がん分子標的治療学会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Che X-F, Takeda Y, Akiyama S, Yamada K, The expression of CNT1 and RRM1 are related to the gemcitabine resistance in the pancreatic gemcitabine resistant cells2010

    • Author(s)
      Minami K, Furukawa T, Komatsu M, Ikeda R, Yamamoto M, Tabata S, Shinsato Y
    • Organizer
      The 20th Japan-Korea Joint Seminar on Pharmacology
    • Place of Presentation
      Kagoshima
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 新規ベンズイミダゾール誘導体及びその用途2012

    • Inventor(s)
      辻川和丈、田中明人、青木俊二、水野裕章、所美雪、古川龍彦
    • Industrial Property Rights Holder
      大阪大学、兵庫医療大学、鹿児島大学
    • Industrial Property Number
      2012-045267
    • Filing Date
      2012-03-01
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 水溶性ホルマザンを生成することができるテトラゾリウムを用いた定量的軟寒天コロニー形成アッセイ2011

    • Inventor(s)
      古川龍彦
    • Industrial Property Rights Holder
      鹿児島大学
    • Industrial Property Number
      2011-219433
    • Filing Date
      2011-10-03
    • Related Report
      2012 Final Research Report 2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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