| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The object of our experiment is to know microRNA regulating telomerase expression. Together with the results of methylation analysis of drug resistant cells, we tried to develop therapeutic strategies for overcoming drug resistance of cancer stem cells. As a result, methylation level of both telomerase and MDR1 promoter lesion was stable during acquisition of drug resistance. Instead, increased expression of telomerase and MDR1 protein which was caused through the activation of transcription factor STAT5, was observed.
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