Elucidation of interaction between bone marrow micro-metastases in breast cancer patients

• Project/Area Number: 22501056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: TAKAHASHI Syunji 公益財団法人がん研究会, がん化学療法センター臨床部, 研究員 (90221358)
• Co-Investigator(Kenkyū-buntansha): ITO Yoshinori 公益財団法人がん研究会, がん化学療法センター臨床部, 研究員 (00261131)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 乳癌 / 骨転移 / 骨髄微小転移 / 骨微小環境 / ビスホスホネート

Research Abstract

To elucidate the interaction of disseminated tumor cells in bone marrow (DTC) and bone microenvironment and the effects of bisphosphonates in early breast cancer, we treated breast cancer patients with neoadjuvant chemotherapy with zoledronic acid (ZA), and examined pathological response and changes of DTC, circulating tumor cells (CTC) and circulating endothelial cells (CEC). We treated 30 patients and had Grade 2 to 3 response in 9 patients. CTC was positive in three patients and all became negative after chemotherapy. CEC increased with chemotherapy. Chemotherapy with ZA may increase CEC, and CEC may become a biomarker of neoadjuvant chemotherapy. DTC was positive in only three patients and tumor cells were few, so it was difficult to investigate interaction between tumor cells and cells in bone micro-environment. It should be necessary to investigate interaction between tumor cells and cells in bone micro-environment in the samples of bone metastases

Research Products

• [Journal Article] Re: Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of three pivotal, randomised, phase 3 trials (2013)
  • Author(s): Araki K, Ito Y, Takahashi S
  • Journal Title: Eur J Cancer
• [Journal Article] [Bone metabolic markers for evaluation of bone metastases] (2013)
  • Author(s): Takahashi S
  • Journal Title: Clin Calcium Volume: (3) Pages: 391-400
• [Journal Article] Prognostic Value of C-reactive Protein, Lactase Dehydrogenase and Anemia in Recurrent or Refractory Aggressive Lymphoma. (2013)
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  • Journal Title: Jpn J Clin Oncol. Volume: 43 Issue: 1 Pages: 37-44
  • DOI: 10.1093/jjco/hys194
  • Peer Reviewed
• [Journal Article] Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases (2012)
  • Author(s): Saad F, Brown JE, Van Poznak C, Ibrahim T, Stemmer SM, Stopeck AT, Diel IJ, Takahashi S, Shore N, Henry DH, Barrios CH, Facon T, Senecal F, Fizazi K, Zhou L, Daniels A, Carriere P, Dansey R
  • Journal Title: Ann Oncol Volume: 23(5) Pages: 1341-7
• [Journal Article] Efficacy of zoledronic acid in postmenopausal Japanese women with early breast cancer receiving adjuvant letrozole: 12-month results (2012)
  • Author(s): Takahashi S, Iwase T, Kohno N, Ishikawa T, Taguchi T, Takahashi M, Horiguchi J, Nakamura S, Hozumi Y, Fukunaga M, Noguchi S
  • Journal Title: Breast Cancer Res Treat Volume: 133(2) Pages: 685-93
• [Journal Article] Safety, Efficacy and Pharmacokinetics of Neratinib (HKI-272) in Japanese Patients with Advanced Solid Tumors: A Phase 1 Dose-escalation Study (2012)
  • Author(s): Ito Y, Suenaga M, Hatake K, Takahashi S, Yokoyama M, Onozawa Y, Yamazaki K Hironaka S, Hashigami K, Hasegawa H, Takenaka N, Boku N
  • Journal Title: Jpn J Clin Oncol Volume: 42(4) Pages: 278-86
• [Journal Article] [Clinical characteristics of bone metastases of breast cancer] (2012)
  • Author(s): Takahashi S
  • Journal Title: Nihon Rinsho Pages: 118-23
• [Journal Article] Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumors and malignant lymphomas. (2012)
  • Author(s): Nishimura N, Nakano K, Ueda K, Kodaira M, Yamada S, Mishima Y, Yokoyama M, Terui Y, Takahashi S, Hatake K.
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• [Journal Article] Prognostic Factors for Overall Survival in Japanese Patients with Metastatic Renal Cell Cancer Treated with Sunitinib (2012)
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  • Peer Reviewed
• [Journal Article] igh thymidine kinase activity is a strong predictive factor for poor prognosis in peripheral T-cell lymphoma treated with cyclophosphamide, adriamycin, vincristine and prednisone. (2012)
  • Author(s): Suzuki K, Terui Y, Nakano K, Nara E, Nasu K, Ueda K, Nishimura N, Mishima Y, Sakajiri S, Yokoyama M, Takahashi S, Hatake K.
  • Journal Title: Leuk Lymphoma. Volume: 53 Issue: 5 Pages: 849-54
  • DOI: 10.3109/10428194.2011.635858
  • Peer Reviewed
• [Journal Article] Feasibility and efficacy of combined cisplatin and irinotecan chemotherapy for poorly differentiated neuroendocrine carcinomas. (2012)
  • Author(s): Nakano K, Takahashi S, Yuasa T, Nishimura N, Mishima Y, Sakajiri S, Yokoyama M, Tsuyama N, Ishikawa Y, Hatake K.
  • Journal Title: Jpn J Clin Oncol. Volume: 42 Issue: 8 Pages: 697-703
  • DOI: 10.1093/jjco/hys085
  • Peer Reviewed
• [Journal Article] Safety, Efficacy, and Pharmacokinetics of Neratinib (HKI-272) in Japanese Patients With Advanced Solid Tumors: A Phase 1 Dose-escalation Study. (2012)
  • Author(s): Ito Y, Suenaga M, Hatake K, Takahashi S, YokoyamaM, Onozawa Y, Yamazaki K, Hironaka S, Hashigami K, Hasegawa H, Takenaka N, Boku N.
  • Journal Title: Jpn J Clin Oncol. Volume: 42 Issue: 4 Pages: 278-86
  • DOI: 10.1093/jjco/hys012
  • Peer Reviewed
• [Journal Article] Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer (2011)
  • Author(s): Yoshinori Ito, Koichi Nagasaki, Yoshio Miki, Takuji Iwase, Futoshi Akiyama, Masaaki Matsuura, Rie Horii, Masujiro Makita, Nahomi Tokudome, Masaru Ushijima, Masataka Yoshimoto, Shunji Takahashi, Tetsuo Noda and Kiyohiko Hatake
  • Journal Title: Cancer Sci Volume: 102(1) Pages: 130-6
  • NAID: 10029288759
• [Journal Article] Treatment outcome and prognostic factors in renal cell cancer patients with bone metastasis (2011)
  • Author(s): Yuasa T, Urakami S, Yamamoto S, Yonese J, Saito K, Takahashi S, Hatake K, Fukui I
  • Journal Title: Clin Exp Metastasis Volume: 28(4) Pages: 405-11
• [Journal Article] Phase I study of dasatinib (BMS-354825) in Japanese patients with solid tumors (2011)
  • Author(s): Takahashi S, Miyazaki M, Okamoto I, Ito Y, Ueda K, Seriu T, Nakagawa K, Hatake K
  • Journal Title: Cancer Sci Volume: 102(11) Pages: 2058-64
  • NAID: 10030245266
• [Journal Article] Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumorsand mal ignant lymphomas (2011)
  • Author(s): Nishimura N, Nakano K, Ueda K, Kodaira M, Yamada S, Mishima Y, Yokoyama M, Terui Y, Takahashi S, Hatake K
  • Journal Title: Support Care Cancer. Volume: (online first) Issue: 2 Pages: 685-93
  • DOI: 10.1007/s10549-012-1973-0
  • Peer Reviewed
• [Journal Article] Incidence, risk factors, and outcomes of osteonecrosis of the jaw : integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases (2011)
  • Author(s): Saad F, Brown JE, Van Poznak C, Ibrahim T, Stemmer SM, Stopeck AT, Diel IJ, Takahashi S, Shore N, Henry DH, Barrios CH, Facon T, Senecal F, Fizazi K, Zhou L, Daniels A, Carriere P, Dansey R
  • Journal Title: Ann Oncol. Volume: 23 Issue: 5 Pages: 1341-7
  • DOI: 10.1093/annonc/mdr435
  • Peer Reviewed
• [Journal Article] Detection of circulating tumor cells in peripheral blood of heavily treated metastatic breast cancer patients (2011)
  • Author(s): Tokudome N, Ito Y, Takahashi S, Kobayashi K, Taira S, Tsutsumi C, Oto M, Oba M, Inoue K, Kuwayama A, Masumura K, Nakayama Y, Watanabe C, Hatake K
  • Journal Title: Breast Cancer Volume: 18 Issue: 3 Pages: 195-202
  • DOI: 10.1007/s12282-011-0259-4
  • NAID: 10029590079
  • Peer Reviewed
• [Journal Article] A lower dose of docetaxel at 60mg/m(2) could be continued longer for controlling peripheral edema in patients with metastatic breast cancer (2011)
  • Author(s): Hosonaga M, Ito Y, Tokudome N, Takahashi S, Iwase T, Hatake K
  • Journal Title: Breast Cancer. Volume: (in press) Issue: 4 Pages: 329-334
  • DOI: 10.1007/s12282-011-0297-y
  • NAID: 10031146735
  • Peer Reviewed
• [Journal Article] Biomarkers to Predict Response to Sunitinib Therapy and Prognosis in Metastatic Renal Cell Cancer (2011)
  • Author(s): Yuasa T, et al
  • Journal Title: Cancer Science Volume: 102 Issue: 11 Pages: 1949-57
  • DOI: 10.1111/j.1349-7006.2011.02054.x
  • NAID: 10030244632
  • Peer Reviewed
• [Journal Article] Phase I study of dasatinib (BMS-354825) in Japanese patients with solid tumors (2011)
  • Author(s): Takahashi S, Miyazaki M, Okamoto I, Ito Y, Ueda K, Seriu T, Nakagawa K, Hatake K
  • Journal Title: Cancer Sci. Volume: 102 Issue: 11 Pages: 2058-64
  • DOI: 10.1111/j.1349-7006.2011.02041.x
  • NAID: 10030245266
  • Peer Reviewed
• [Journal Article] Phase I Dose-Escalation Studies of BMS-641988 in Patients with Castration-Resistant Prostate Cancer. (2011)
  • Author(s): Dana Rathkopf, Glenn Liu, Michael A Carducci, Mario A Eisenberger, Aseem Anand, Michael J Morris, Susan F Slovin, Yasutsuna Sasaki, Shunji Takahashi, Seiichiro Ozono, Nga Kit Eliza Fung, Shinta Cheng, Jinping Gan, Marco Gottardis, Mary T.Obermeier, Jyotsna Reddy, Steven Zhang, Blisse J.Vakkalagadda, George Wilding, Howard I.Scher.
  • Journal Title: Clin Cancer Res Volume: 17 Pages: 880-887
  • Peer Reviewed
• [Journal Article] Treatment outcome and prognostic factors in renal cell cancer patients with bone metastasis. (2011)
  • Author(s): Yuasa T, Urakami S, Yamamoto S, Yonese J, Saito K, Takahashi S, Hatake K, Fukui I.
  • Journal Title: Clin Exp Metastasis. Volume: (Epub)
  • Peer Reviewed
• [Journal Article] Bone metastasis and poor performance status are prognostic factors for survival of carcinoma of unknown primary site in patients treated with systematic chemotherapy (2010)
  • Author(s): Kodaira M, Takahashi S, Yamada S, Ueda K, Mishima Y, Takeuchi K, Yamamoto N, Ishikawa Y, Yokoyama M, Saotome T, Terui Y, Hatake K
  • Journal Title: Ann Oncol Volume: (6) Pages: 1163-7
• [Journal Article] High-grade breast cancers include both highly sensitive and highly resistant subsets to cytotoxic chemotherapy (2010)
  • Author(s): Osako T, Horii R, Matsuura M, Domoto K, Ide Y, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F
  • Journal Title: J Cancer Res Clin Oncol Volume: (9) Pages: 1431-8
• [Journal Article] Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy (2010)
  • Author(s): Osako T, Horii R, Matsuura M, Ogiya A, Domoto K, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F
  • Journal Title: J Cancer Res Clin Oncol Volume: (2) Pages: 233-41
• [Journal Article] Relationship between bone mineral density and androgen-deprivation therapy in Japanese prostate cancer patients (2010)
  • Author(s): Yuasa T, Maita S, Tsuchiya N, Ma Z, Narita S, Horikawa Y, Yamamoto S, Yonese J, Fukui I, Takahashi S, Hatake K, Habuchi T
  • Journal Title: Urology Volume: 75(5) Pages: 1131-7
• [Journal Article] Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons (2010)
  • Author(s): Yoneda T, Hagino H, Sugimoto T, Ohta H, Takahashi S, Soen S, Taguchi A, Toyosawa S, Nagata T, Urade M
  • Journal Title: J Bone Miner Metab Volume: 28(4) Pages: 365-83
• [Journal Article] Relationship between bone mineral density and androgen-deprivation therapy in Japanese prostate cancer patients. (2010)
  • Author(s): Yuasa T, Maita S, Tsuchiya N, Ma Z, Narita S, Horikawa Y, Yamamoto S, Yonese J, Fukui I, Takahashi S, Hatake K, Habuchi T.
  • Journal Title: Urology Volume: 75(5) Pages: 1131-1137
  • Peer Reviewed
• [Journal Article] Complete resection after imatinib treatment of a gastrointestinal stromal tumor of the ileum with peritoneal metastases : report of a case. (2010)
  • Author(s): Akiyoshi T, Oya M, Fujimoto Y, Kuroyanagi H, Ueno M, Yamaguchi T, Takahashi S, Hatake K, Katori M, Yamamoto N, Muto T.
  • Journal Title: Surg Today Volume: 40 Pages: 272-276
  • Peer Reviewed
• [Journal Article] Phase I study of inotuzumab ozogamicin(CMC-544)in Japanese patients with follicular lymphoma pretreated with rituximab-based therapy. (2010)
  • Author(s): Ogura M, Tobinai K, Hatake K, Uchida T, Kasai M, Oyama T, Suzuki T, Kobayashi Y, Watanabe T, Azuma T, Mori M, Terui Y, Yokoyama M, Mishima Y, Takahashi S, Ono C, Ohata J.
  • Journal Title: Cancer Sci. Volume: 101 Pages: 1840-1845
  • Peer Reviewed
• [Journal Article] In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate. (2010)
  • Author(s): Mitsuhashi J, Hosoyama H, Tsukahara S, Katayama K, Noguchi K, Ito Y, Hatake K, Aiba K, Takahashi S, Sugimoto Y.
  • Journal Title: J Gene Med. Volume: 12 Pages: 596-603
  • Peer Reviewed
• [Journal Article] Sorafenib-induced erythema multiforme for metastatic renal cell carcinoma. (2010)
  • Author(s): Kodaira M, Takahashi S, Takeuchi K, Yuasa T, Saotome T, Yonese J, Fukui I, Hatake K.
  • Journal Title: Ann Oncol. Volume: 21 Pages: 1563-1565
  • Peer Reviewed
• [Journal Article] Bisphosphonate-related osteonecrosis of the jaw : position paper from the Allied Task Force Committee of Japanese Society for B one and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxill of acial Radiology, and Japanese Society of Oral and Maxillofaci al Surgeons. (2010)
  • Author(s): Yoneda T, Hagino H, Sugimoto T, Ohta H, Takahashi S, Soen S, Taguchi A, Toyosawa S, Nagata T, Urade M.
  • Journal Title: J Bone Miner Metab. Volume: 28 Pages: 365-383
  • Peer Reviewed
• [Journal Article] Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer. (2010)
  • Author(s): Yoshinori Ito, Koichi Nagasaki, Yoshio Miki, Takuj Iwase, Futoshi Akiyama, Masaaki Matsuura, Rie Horii, Masujiro Makita, Nahomi Tokudome, Masaru Ushijima, Masataka Yoshimoto, Shunji Takahashi, Tetsuo Noda, Kiyohiko Hatake.
  • Journal Title: Cancer Sci. Volume: 120 Pages: 130-136
  • NAID: 10029288759
  • Peer Reviewed
• [Journal Article] High-grade breast cancers include both highly sensitive and highly resistant subsets to cytotoxic chemotherapy. (2010)
  • Author(s): Osako T, Horii R, Matsuura M, Domoto K, Ide Y, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F
  • Journal Title: J Cancer Res Clin Oncol. Volume: 136 Pages: 1431-1438
  • Peer Reviewed
• [Journal Article] Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy. (2010)
  • Author(s): Osako T, Horii R, Matsuura M, Ogiya A, Domoto K, Miyagi Y, Takahashi S, Ito Y, Iwase T, Akiyama F.
  • Journal Title: J Cancer Res Clin Oncol. Volume: 136 Pages: 233-241
  • Peer Reviewed
• [Presentation] 日本臨床腫瘍学会・日本乳癌学会 合同シンポジウム Biologyから考える乳がん治療戦略 Progress and future of bone-targeted therapy (2012)
  • Author(s): 高橋俊二
  • Organizer: 第20回 日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-27
• [Presentation] 教育講演 支持療法2:骨転移治療の新展開 (2012)
  • Author(s): 高橋俊二
  • Organizer: 第10回 日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-26
• [Presentation] デノスマブとゾレドロン酸を比較した第III相二重盲検比較試験の統合解析における顎骨壊死の発現率と転帰 (2012)
  • Author(s): 高橋俊二
  • Organizer: 第20回 日本乳癌学会学術総会
  • Place of Presentation: 熊本
  • Year and Date: 2012-06-30
• [Presentation] 早期乳癌患者に対するゾレドロン酸併用術前化学療法 (2012)
  • Author(s): 中山美恵、高橋俊二、河合佑子、小林心、小林隆之、堤千寿子、田辺真彦、伊藤良則
  • Organizer: 第2相試験 中間報告 第20回 日本乳癌学会学術総会
  • Place of Presentation: 熊本
  • Year and Date: 2012-06-28
• [Presentation] 骨転移におけるRANK/RANKL系の役割 (2011)
  • Author(s): 高橋俊二
  • Organizer: 日本がん治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-27
• [Presentation] 骨転移治療の重要性とビスフォスフォネート製剤のリスクベネフィット (2011)
  • Author(s): 高橋俊二
  • Organizer: 日本口腔外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-22
• [Presentation] 骨転移治療の重要性とビスフォスフォネート製剤のリスクペネフィット (2011)
  • Author(s): 高橋俊二
  • Organizer: 日本口腔外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-22
• [Presentation] Zoledronic acid inhibits adjuvant letrozole-associated bone loss in postmenopausal Japanese women with early breast cancer. (2011)
  • Author(s): S. Takahashi, T. Iwase, N. Kohno, T. Ishikawa, T. Taguchi, M. Takahashi, J. Horiguchi, S. Nakamura, M. Fukunaga, S. Noguchi
  • Organizer: 米国臨床腫瘍学会
  • Place of Presentation: シカゴ
  • Year and Date: 2011-06-04
• [Presentation] Zoledronic acid inhibits adjuvant letrozole-associated bone loss in postmenopausal Japanese women with early breast cancer (2011)
  • Author(s): S.Takahashi, T.Iwase, N.Kohno, T.Ishikawa, T.Taguchi, M.Takahashi, J.Horiguchi, S.Nakamura, M.Fukunaga, S.Noguchi
  • Organizer: 米国臨床腫瘍学会
  • Place of Presentation: シカゴ
  • Year and Date: 2011-06-04
• [Presentation] 前立腺癌骨転移の薬物治療―腫瘍内科の立場から 前立腺癌シンポジウム (2010)
  • Author(s): 高橋俊二、湯浅健、福井巌
  • Organizer: 東京コンファレンスセンター
  • Place of Presentation: 品川
  • Year and Date: 2010-12-12
• [Presentation] 前立腺癌骨転移の薬物治療-腫瘍内科の立場から (2010)
  • Author(s): 高橋俊二、湯浅健、福井巌
  • Organizer: 前立腺癌シンポジウム
  • Place of Presentation: 東京コンファレンスセンター・品川
  • Year and Date: 2010-12-12
• [Presentation] 乳癌骨転移の臨床 (2010)
  • Author(s): 高橋俊二
  • Organizer: 癌と骨病変研究会
  • Place of Presentation: 東京 千代田放送会館
  • Year and Date: 2010-11-19
• [Presentation] 病態に基づいた骨転移に対する治療:臨床での実際 (2010)
  • Author(s): 高橋俊二
  • Organizer: 日本癌治療学会イブニングセミナー
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] 分子標的治療の有害事象対策:チーム医療 (2010)
  • Author(s): 高橋俊二
  • Organizer: 腎がん研究会
  • Place of Presentation: 東京 椿山荘
  • Year and Date: 2010-07-18
• [Presentation] アロマターゼ阻害剤による骨代謝障害の予測因子 (2010)
  • Author(s): 高橋俊二、徳留なほみ、伊藤良則、岩瀬拓士、畠清彦
  • Organizer: 日本乳癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-25
• [Presentation] 早期乳癌患者に対するゾレドロン酸併用術前化学療法 第2相試験 中間報告
  • Author(s): 中山美恵、高橋俊二、河合佑子、小林心、小林隆之、堤千寿子、田辺真彦、伊藤良則
  • Organizer: 第20回 日本乳癌学会学術総会
  • Place of Presentation: 熊本
• [Presentation] デノスマブとゾレドロン酸を比較した第III相二重盲検比較試験の統合解析における顎骨壊死の発現率と転帰
  • Author(s): 高橋俊二
  • Organizer: 第20回 日本乳癌学会学術総会
  • Place of Presentation: 熊本
• [Presentation] 教育講演 支持療法２：骨転移治療の新展開
  • Author(s): 高橋俊二
  • Organizer: 第10回 日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 日本臨床腫瘍学会・日本乳癌学会 合同シンポジウム Biologyから考える乳がん治療戦略 Progress and future of bone-targeted therapy
  • Author(s): 高橋俊二
  • Organizer: 第20回 日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Invited
• [Book] がん骨転移治療?BP治療によるBone management (2012)
  • Author(s): 高橋俊二 編
  • Publisher: 先端医学社
• [Book] がん骨転移治療―BP治療によるBone management (2012)
  • Author(s): 高橋俊二 編
  • Total Pages: 242
  • Publisher: 先端医学社
• [Book] がん骨転移治療-ビスフォスフォネート治療によるBone management (2012)
  • Author(s): 高橋俊二編
  • Total Pages: 242
  • Publisher: 先端医学社
• [Book] 原発不明がん適切な診断・治療のポイント (2012)
  • Author(s): 向井博文編、高橋俊二, 他
  • Total Pages: 23
  • Publisher: MEDICAL VIEW社
• [Book] 乳癌の骨マネジメント (2011)
  • Author(s): 中村清吾、林直輝 編 高橋俊二他著
  • Publisher: 篠原出版新社
• [Book] 乳癌の骨マネジメント (2011)
  • Author(s): 中村清吾、林直輝編, 高橋俊二, 他
  • Total Pages: 20
  • Publisher: 篠原出版新社