| Project/Area Number |
22501057
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Clinical oncology
|
|---|
| Research Institution | National Cancer Center Japan |
|---|
Principal Investigator |
KONDO Tadashi 独立行政法人国立がん研究センター, 研究所, 分野長 (30284061)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWAI Akira 独立行政法人国立がん研究センター, 中央病院, 医長 (90252965)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 化学療法 / 転移性骨腫瘍 / 創薬標的 / プロテオーム解析 / 網羅的解析 |
|---|
| Research Abstract |
To reveal the molecular backgrounds of metastatic bone tumor, we created the expression profiles of primary tumor tissues and bone metastatic tissues, which were obtained and storaged at the time of surgery. Lung cancers, breast cancers, hepatocellular carcinomas, colorectal cancers, pancreatic cancers, gastric cancers, renal cell carcinomas, and parotid glad tumors were included this study. Protein expression profiles were created by two-dimensional difference gel electrophoresis, and PROTOMAP. Global microRNA expression was examined by the microarray. We identified genes whose expression levels were aberrantly regulated in the bone-metastatic tumors compared with the primary tumors. The functional significances of the identified genes were verified by the in vitro experiments.
|
