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Association between genetic polymorphisms of drug-metabolizingenzymes and factors of liver cancer

Research Project

Project/Area Number 22501059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cancer epidemiology and prevention
Research InstitutionShowa University

Principal Investigator

YASUHARA Hajime  昭和大学, 医学部, 名誉教授 (70053999)

Co-Investigator(Kenkyū-buntansha) KURATA Norimitsu  昭和大学, 教養部, 教授 (80231299)
NISHIMURA Yuki  昭和大学, 医学部, 講師 (40276572)
IWASE Mariko  昭和大学, 医学部, 助教 (70424273)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsCYP2C19 / 肝臓癌 / 遺伝子多型 / サイトカイン / 転移 / 転移性肝臓癌 / 遺伝子環境交互作用 / 発がんメカニズム
Research Abstract

This study was conducted to clarify the association between drug-metabolizing enzyme CYP2C19 gene mutation and liver cancer susceptibility. 21 liver and blood samples were donated from Japanese liver cancer patients who received partial hepatectomy. The results indicated that the gene mutation found in high frequency in metastatic liver cancer patients occur congenitally rather than arise in peripheral tumor site acquired by cancer condition.CYP2C19 activity decreased in all samples and the degree was associated with changes in several cytokines, but did not correlate with the genotype of the enzyme. For the prevention of metastasis and for the proper treatment of liver cancer, further studies elucidating the mechanisms and significance of the results obtained and clarifying the role of CYP2C19 in cancer patients are needed.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011

All Presentation (3 results)

  • [Presentation] CYP2C19遺伝子変異と肝臓癌発症リスクの関連2011

    • Author(s)
      西村有希、倉田知光、岩瀬万里子、安原 一、小林靖奈、山元俊憲、青木武士、村上雅彦、齋藤光次、小林真一
    • Organizer
      第32回日本臨床薬理学会年会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] CYP2C19遺伝子変異の発癌への関与2011

    • Author(s)
      西村有希、倉田知光、岩瀬万里子、小林靖奈、山元俊憲、安原 一
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] The participation of CYP2C19 gene mutation in liver cancer2011

    • Author(s)
      西村有希
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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