A double-blind randomization placebo comparison clinical trial was performed using the oral vitamin D supplement for the patient after surgical treatment of lung cancer
| Project/Area Number |
22501060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cancer epidemiology and prevention
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
TADASHI Akiba 東京慈恵会医科大学, 医学部, 教授 (10192907)
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| Co-Investigator(Kenkyū-buntansha) |
URASHIMA Mitsuyoshi 東京慈恵会医科大学, 医学部, 教授 (80203602)
MORIKAWA Toshiaki 東京慈恵会医科大学, 医学部, 教授 (60292907)
SATO Shuji 東京慈恵会医科大学, 医学部, 准教授 (80205921)
ODAKA Makoto 東京慈恵会医科大学, 医学部, 講師 (20233554)
YAMASHITA Makoto 東京慈恵会医科大学, 医学部, 講師 (10287302)
森川 利昭 東京慈恵会医科大学, 医学部, 教授 (60292025)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | ビタミンDサプリメント / 肺癌 / 肺がん / ビタミンD / 再発予防 / 手術 |
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| Outline of Final Research Achievements |
A double-blind randomization placebo comparison clinical trial was performed using the oral vitamin D supplement for the patient after surgical treatment of lung cancer. Enrolled patient was 202. As for the vitamin D receptor gene analysis, Fok1 was studied in 137 and UGT2B17 in 139. The 25OH vitamin D serum concentration measurement was performed in 157 people. Among them, 36 recurred and 15 were died so far.
More than 18ng/mL 25OHD compared it to under before internal use of supplement, a survival rate was significantly improved as a result of analysis. The death and recurrence rate did not have the significant difference so far between vitamin D group and placebo group.
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Report
(6 results)
Research Products
(44 results)
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[Journal Article] Pulmonary pleomorphic carcinoma detected as a result of pneumothorax and the subsequent occurrence of multiple cystic metastases.2014
Author(s)
Yamakawa H, Yoshida M, Yabe M, Baba Y, Baba E, Katagi H, Ishikawa T, Takagi M, Nakada T, Akiba T, Kuwano K.
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Journal Title
Case Rep Med.
Volume: 2014
Pages: 219273-219273
DOI
Related Report
Peer Reviewed
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[Journal Article] Multiple pulmonary metastases following by total removal of bilateral parasagital meningioma with complete occlusion of superior sagittal sinus: case report.2012
Author(s)
(Nakano M), Tanaka T, Nakamura A, Watanabe M, Kato N, Arai T, Hasegawa Y, Akiba T, Marushima H, Kanetsuna Y, Abe T.
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Journal Title
Case Report Neurol Med
Volume: 2012
Pages: 121470-121470
DOI
Related Report
Peer Reviewed
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