The impact of peripheral blood gamma-delta T cells to recurrence of the patients with early stage renal cell cancer.

• Project/Area Number: 22501061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cancer epidemiology and prevention
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KOBAYASHI Hirohito 東京女子医科大学, 医学部, 講師 (80318047)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ガンマデルタ型T細胞 / 腎細胞がん / 腫瘍免疫 / 再発予測因子 / 再発予防 / ガンマ・デルタ型T細胞 / 腎細胞癌 / 予後 / ガンマ･デルタ型T細胞 / 腎癌 / γδ型T細胞 / 予後マーカー

Outline of Final Research Achievements

Surgical treatment is the first line treatment for the patients with early stage renal cell cancer (RCC). But, it is well known that about 10% of these patients who were performed appropriate treatments will become to recur of RCC and also late recurrence was often found in these patients more than 10 years after the surgery. Although these phenomena are thought to be closely associated with the immunological statement of the hosts, what type of immune cells play a role of immunological surveillance against RCC are still unclear. In this study, we showed that peripheral blood gamma-delta T cells might inhibit the recurrence of RCC for the patients of early stage RCC after the surgery. Our results will give a cue for an appropriate clinical follow-up schedule for these patients whose peripheral blood gamma delta T cells were low number and help to develop of a new immunotherapy for recurrence prevention.

Research Products

• [Journal Article] γδ T cell therapy-A Review (2015)
  • Author(s): Hirohito Kobayashi, Yoshimasa Tanaka
  • Journal Title: Pharmaceuticals Volume: 8 Issue: 1 Pages: 40-61
  • DOI: 10.3390/ph8010040
  • Peer Reviewed / Open Access
• [Journal Article] Exploring immune therapy for renal cancer (2011)
  • Author(s): Matsushita H, Kakimi K, Tomita Y, Tatsugami K, Naito S, Suekane S, Noguchi M, Moriya F, Matsuoka K, Itoh K, Kobayashi H, Eto M, Takahashi W, Kawano Y, Wada Y
  • Journal Title: Int.J.Urol Volume: 18 Pages: 412-421
  • NAID: 10030822756
  • Peer Reviewed
• [Journal Article] Phase 1/11 study of adoptive transfer of Y^δ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma (2011)
  • Author(s): Kobayashi H, Tanaka Y, Yagi J, Minato N, Tanabe K
  • Journal Title: Cancer Immunol Immunother Volume: 60 Pages: 1075-1084
  • Peer Reviewed
• [Journal Article] Expression and function of PD-1 in human Y^δ T cells that recognize phosphoantigens (2011)
  • Author(s): Iwasaki M, Tanaka Y, Kobayashi H, Murata-Hirai K, Miyabe H, Sugie T, Toi M, Minato N
  • Journal Title: Eur J Immunol. Volume: 41 Pages: 345-355
  • Peer Reviewed
• [Journal Article] A new indicator of favorable prognosis in locally advanced renal cell carcinomas : gamma delta T-cells in peripheral blood (2011)
  • Author(s): Kobayashi H, Tanaka Y, Nakazawa H, Yagi J, Minato N, Tanabe K
  • Journal Title: Anticancer Res. Volume: 31 Pages: 1027-1031
  • Peer Reviewed
• [Journal Article] A New Indicator of a Favorable Prognosis in Locally Advanced Renal Cell Carcinomas : γδ T-Cells in Peripheral Blood
  • Author(s): Hirohito Kobayashi
  • Journal Title: Anticancer Research Volume: (In Press)
  • Peer Reviewed
• [Presentation] がんに対する免疫細胞療法 (2011)
  • Author(s): 小林博人
  • Organizer: 第18回日本輸血・細胞療法学会秋季総会
  • Place of Presentation: 浦和
  • Year and Date: 2011-10-21
• [Presentation] New strategy of adoptive immunotherapy using gamma-delta T cells (2011)
  • Author(s): 小林博人
  • Organizer: 第2回アジア細胞治療法学会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-10-18
• [Presentation] Gamma delta T cells : application of cancer immunotherapy against renal cell carcinoma (2011)
  • Author(s): 小林博人
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] 泌尿器癌に対する標的免疫療法 (2011)
  • Author(s): 小林博人
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-22
• [Presentation] A New Sign of a Favorable Prognosis in Locally Advanced Renal Cell Carcinomas : γδ T Cells in Peripheral Blood (2010)
  • Author(s): 小林博人
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-30