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Investigation on sensitized status to plastic resin materials

Research Project

Project/Area Number 22510036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental impact assessment/Environmental policy
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

KAWAMOTO Toshihiro  産業医科大学, 医学部, 教授 (60177748)

Co-Investigator(Kenkyū-buntansha) OYAMA Tsunehiro  産業医科大学, 医学部, 准教授 (00309965)
TANAKA Masayuki  産業医科大学, 医学部, 助教 (80412633)
TSUJI Mayumi  産業医科大学, 医学部, 講師 (40457601)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords健康影響評価 / アレルギー / 樹脂 / プラスチック / 免疫グロブリン / 化学物質 / IgG / 実態調査 / 蛋白質付加体 / ドットブロット
Research Abstract

This study aimed to verify a hypothesis that recent increase of allergy patients is partly explained by antibodies against plastic resin materials. A new method to detect serum antibodies against plastic resin materials were developed by using western-dot blotting. Among 100 wonlen, the positive rates of IgG against phthalic anhydrate and glutaraldehyde were very high. That against toluene 2,4-diisocyanate was around 50%, and those against bisphenol A diglycidyl ether, P-henylenediamine and formaldehyde were very low. The antibody titers against the causal chemical were related to the severity of allergies. From this study, it is suggested that antibodies against plastic resin materials related the onset of allergies.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (63 results)

All 2013 2012 2011 2010

All Journal Article (31 results) (of which Peer Reviewed: 28 results) Presentation (27 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Characterization of placental transfer of polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls in normal pregnancy2013

    • Author(s)
      Tsukimori K, Morokuma S, Hori T, Takahashi K, Hirata T, Otera Y, Fukushima K, Kawamoto T, Wake N
    • Journal Title

      The Journal of Obstetrics and Gynaecology Research

      Volume: 39(1) Issue: 1 Pages: 83-90

    • DOI

      10.1111/j.1447-0756.2012.01906.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential genotoxic effects of subchronic exposure to ethyl tertiary butyl ether in the livers of Aldh2 knockout and wild-type mice2012

    • Author(s)
      Wang Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS
    • Journal Title

      Arch Toxicol

      Volume: 86 Pages: 675-682

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism2012

    • Author(s)
      Oyama T, Uramoto H, Kagawa N, Yoshimatsu T, Osaki T, Nakanishi R, Nagaya H, Kaneko K, Muto M, Kawamoto T, Tanaka F, Gotoh A
    • Journal Title

      Frontiers in Bioscience

      Volume: S4 Pages: 1539-1546

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese Children2012

    • Author(s)
      Tsuji M, Vogel CFA, Koriyama C, Akiba S, Katoh T, Kawamoto T, Matsumura F
    • Journal Title

      Chemosphere

      Volume: 87(11) Issue: 11 Pages: 1228-1234

    • DOI

      10.1016/j.chemosphere.2012.01.022

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of ethanol on the formation of N^<2-> ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus2012

    • Author(s)
      Yu H-S, Oyama T, Matsuda T, Isse T, Yamaguchi T, Tanaka M, Tsuji M, Kawamoto T
    • Journal Title

      Biomarkers

      Volume: 17 Issue: 3 Pages: 269-274

    • DOI

      10.3109/1354750x.2012.666675

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects and Action Mechanisms of Korean Pear(Pyrus pyrifolia cv. Shingo) on Alcohol Detoxification2012

    • Author(s)
      Lee HS, Isse T, Kawamoto T, Woo HS, Kim AK, Park JY, Yang M.
    • Journal Title

      Phytother Res

      Volume: 17 Issue: 11 Pages: 269-274

    • DOI

      10.1002/ptr.4630

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-22 mRNA expression in blood sample as a useful biomarker for assessing the adverse health effects of PCBs on allergic children2012

    • Author(s)
      Tsuji M, Kawamoto T, Koriyama C, Matsumura F
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 9 Issue: 12 Pages: 4321-4332

    • DOI

      10.3390/ijerph9124321

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential genotoxic effects of subchronic exposure to ethyl tertiary butyl ether in the livers of Aldh2 knockout and wild-type mice.2012

    • Author(s)
      Wang Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS
    • Journal Title

      Archives of Toxicology

      Volume: 86 Issue: 4 Pages: 675-682

    • DOI

      10.1007/s00204-011-0779-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of coffee intake on urinary hippuric acid concentration2011

    • Author(s)
      Ogawa M, Suzuki Y, Endo Y, Kawamoto T, Kayama F
    • Journal Title

      Industrial Health

      Volume: 49 Pages: 195-202

    • NAID

      130004828607

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice2011

    • Author(s)
      Shimizu Y, Sakai A, Menuki K, Mori T, Isse T, Oyama T, Kawamoto T, Nakamura T
    • Journal Title

      Bone

      Volume: 48 Pages: 1075-1086

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldh2 Knockout Mice Were More Sensitive to DNA Damage in Leukocytes due to Ethyl Tertiary Butyl Ether Exposure2011

    • Author(s)
      Weng Z, Suda M, Katsumi Ohtani K, Mei N, Kawamoto T, Nakajima T and Wang R-S
    • Journal Title

      Industrial Health

      Volume: 49

    • NAID

      130004828633

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice2011

    • Author(s)
      Li Q, Kobayashi M, Inagaki H, Hirata Y, Hirata K, Shimizu T, Wang R-S, Suda M, Kawamoto T, Nakajima T, Kawada T
    • Journal Title

      International Journal of Immunopathology and Pharmacology

      Volume: 24 Pages: 837-847

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Historical review of development of environmental quality standards and guideline values for air pollutants in Japan2011

    • Author(s)
      Kawamoto T, Pham TTP, Matsuda T, Oyama T, Tanaka M, Yu H-S, Uchiyama I.
    • Journal Title

      International Journal of Hygiene and Enviromental Health

      Volume: 214 Pages: 296-304

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of coffee intake on urinary hippuric acid concentration2011

    • Author(s)
      Ogawa M, et al
    • Journal Title

      Ind.Health

      Volume: 49 Pages: 195-202

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice2011

    • Author(s)
      Shimizu Y, et al
    • Journal Title

      Bone

      Volume: 48 Issue: 5 Pages: 1075-1086

    • DOI

      10.1016/j.bone.2011.01.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldh2 knockout mice were more sensitive to DNA damage in leukocytes due to ethyl tertiary butyl ether exposure2011

    • Author(s)
      Weng Z, et al
    • Journal Title

      Ind.Health

      Volume: 49 Pages: 396-399

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice2011

    • Author(s)
      Li Q, et al
    • Journal Title

      Int.J.Immunopathol.Pharmacol.

      Volume: 24 Pages: 837-847

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Historical review of development of environmental quality standards and guideline values for air pollutants in Japan2011

    • Author(s)
      Kawamoto T, et al
    • Journal Title

      Int.J.Hyg.Environ.Health

      Volume: 214 Issue: 4 Pages: 296-304

    • DOI

      10.1016/j.ijheh.2011.05.007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes2010

    • Author(s)
      Kim YD, Eom SY, Zhang YW, Kim H, Park JD, Yu SD, Lee CH, Arashidani K, Kawamoto T, Kim H
    • Journal Title

      Human Experimental Toxicology

      Volume: 30(4) Pages: 338-342

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehaydrogenase deficient mice (Aldh2-/-)2010

    • Author(s)
      Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu H-S, Pham TTP, Tanaka M, Kagawa N, Kanako K, Kawamoto T
    • Journal Title

      Frontiers in Bioscience E

      Volume: 2 Pages: 1344-1354

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldehyde dehydrogenase 2 knockout accentuates ethano-induced cardiac depression: role of protein phosphatases2010

    • Author(s)
      Ma H, Yu L, Byra EA, Hu N, Kitagawa K, Nakayama KI, Kawamoto T, Ren J
    • Journal Title

      Journal fo Molecular and Cellular Cardiology

      Volume: 49(2) Pages: 322-329

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of acetaldehyde-derived DNA adducts due to alcohol exposure2010

    • Author(s)
      Yu H-S, Oyama T, lsse T, Kitagawa K, Pham TTP, Tanaka M, Kawamoto T
    • Journal Title

      Chemico-Biological Interactions

      Volume: 188 Pages: 367-375

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison between the Local Lymph Node Assay and Tryptophan Fluorescence Assay2010

    • Author(s)
      Pham TTP, Isse T, Yu H-S, Oyama T, Tanaka M, Kawamoto T
    • Journal Title

      Journal of Preventive Medicine

      Volume: 5(3) Pages: 3-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 二次健康診断としての生物学的モニタリングの実施状況2010

    • Author(s)
      圓藤吟史, 他
    • Journal Title

      季刊労働衛生管理

      Volume: 21 Pages: 41-44

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes2010

    • Author(s)
      Kim YD, et al.
    • Journal Title

      Hum Exp Toxicol

      Volume: 30 Pages: 338-342

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2)2010

    • Author(s)
      Oyama T, et al.
    • Journal Title

      Front Biosci

      Volume: 2 Pages: 1344-1354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldehyde dehydrogenase 2 knockout accentuates ethano-induced cardiac depression : role of protein phosphatases2010

    • Author(s)
      Ma H, et al.
    • Journal Title

      J Mol Cell Cardiol

      Volume: 49 Pages: 322-329

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison between the local lymph node assay and tryptophan fluorescenceassay2010

    • Author(s)
      Pham TTP, et al.
    • Journal Title

      J Prev Med

      Volume: 5 Pages: 3-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "エコチル調査"の概要とコアセンターの役割 動き出した"エコチル調査"-環境省 子どもの健康と環境に関する全国調査2010

    • Author(s)
      川本俊弘, 他
    • Journal Title

      医学のあゆみ

      Volume: 235 Pages: 1093-1098

    • Related Report
      2010 Annual Research Report
  • [Journal Article] エコチル調査-パイロット調査2010

    • Author(s)
      諸隈誠一, 他
    • Journal Title

      Biophilia(季刊ビオフィリア)

      Volume: 6 Pages: 72-75

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Formation of acetaldehyde-derived DNA adducts due to alcohol exposure2010

    • Author(s)
      Hu HS, et al.
    • Journal Title

      Chem Bio Interact

      Volume: 188 Pages: 367-375

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 樹脂(プラスチック)原料に対する特異的抗体の検出2013

    • Author(s)
      川本俊弘、辻真弓、余旭勝
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば)
    • Related Report
      2012 Final Research Report
  • [Presentation] 樹脂(プラスチック)原料に対する特異的抗体の検出2013

    • Author(s)
      川本俊弘、辻 真弓、余 旭勝
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくば市 つくばサイエンス・インフォメーションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pilot studies in JECS2012

    • Author(s)
      Kawamoto T
    • Organizer
      Japan Environmental and Children's Study (JECS) International Symposium in Kitakyushu
    • Place of Presentation
      Kitakyushu, Japan
    • Year and Date
      2012-02-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Pilot studies in JECS2012

    • Author(s)
      Kawamoto T
    • Organizer
      Japan Environmental and Children's Study (JECS) International Symposium in Kitakyushu
    • Place of Presentation
      Kitakyushu International Conference Center(福岡県)(招待講演)
    • Year and Date
      2012-02-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 化学物質曝露による特異的抗体の検出に関する研究2012

    • Author(s)
      余旭勝、辻真弓、吉田安宏、田中政幸、川本俊弘
    • Organizer
      第30回産業医科大学学会
    • Place of Presentation
      産業医科大学ラマツィー二・ホール(北九州)
    • Related Report
      2012 Final Research Report
  • [Presentation] The Pilot Study for Japan Environment and Children' s Study (JECS)2012

    • Author(s)
      Kawamoto T, Kayama F, Morokuma S, Katoh T, Toda E, Hayashi N, Ohya Y, Satoh H
    • Organizer
      nternatioanl Society for Environmental Epidemiology 24rh Annual Conference (ISEE 2012)
    • Place of Presentation
      Columbia, SC, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] The Pilot Study for Japan Environment and Children' s Study (JECS). International Society for Exposure Sciences (ISES)2012

    • Author(s)
      Kawamoto T, Kayama F, Morokuma S, Katoh T, Toda E, Hayashi N, Ohay Y, Satoh H
    • Organizer
      22^<nd> Annual Meeting
    • Place of Presentation
      Seattle, WA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Induced heme oxigenase 1 and thioredoxine reductase 1 are the potential factors which protect ethanol-exposed liver tissue with inactive ALDH22012

    • Author(s)
      Matsumoto A, Kawamoto T, Vasiliou V, Ichiba M
    • Organizer
      16th Alcohol World Congress of International Society for Biomedical Research on Alcoholism
    • Place of Presentation
      Sapporo Convention Center, Sapporo, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association of serum residues of PCBs with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children2012

    • Author(s)
      Tsuji M, Kawamoto T, Koriyama C, Akiba S, Masayuki Tanaka M, Yu H-S, Vogel FAC, Matsumura F
    • Organizer
      SETAC Asia Pacific 2012 Meeting. The Society of Environmental Toxicology and Chemistry
    • Place of Presentation
      ANA Hotel Kumamoto New Sky, Kumamoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Pilot Study for Japan Environment and Children’s Study (JECS)2012

    • Author(s)
      Kawamoto T, Kayama F, Morokuma S, Katoh T, Toda E, Hayashi N, Ohya Y, Satoh H.
    • Organizer
      22nd Annual Meeting of International Society for Exposure Science (ISES)
    • Place of Presentation
      The Westin Seattle, Seattle, WA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 化学物質曝露による特異的抗体の検出に関する研究2012

    • Author(s)
      余 旭勝 他
    • Organizer
      第30回産業医科大学学会
    • Place of Presentation
      北九州市 産業医科大学ラマツィーニ・ホール
    • Related Report
      2012 Annual Research Report
  • [Presentation] 未来の子どもたちのために~子どもの健康と環境に関する全国調査について2011

    • Author(s)
      川本俊弘
    • Organizer
      第21回福岡母性衛生学会
    • Place of Presentation
      北九州国際会議場(福岡県)(招待講演)
    • Year and Date
      2011-07-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Aquantitatively prediction of the sensitizing Potentials by measuring tryptophan fluorescence2011

    • Author(s)
      Kawamoto T, Yu H-S, Pham TTP, Tanaka M, Askew DJ, Shibata E, Isse T
    • Organizer
      The 47^<th> Congress of the European Societies of Toxicology (EuroTox)
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] Establishnlent of EQSs and Guideline Values for Plastic Resins (vinyl chloride monomer) and Other Hazardous Air Pollutants2011

    • Author(s)
      Kawamoto T, Yu H-S, Oyama T, Tanaka M, Anan A, Kawamoto R, Uchiyama I
    • Organizer
      The 47^<th> Congress of the European Societies of Toxicology (EuroTox)
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] A quantitatively prediction of the sensitizing potentials by measuring tryptophan fluorescence2011

    • Author(s)
      Kawamoto T, et al
    • Organizer
      The 47^<th> Congress of the European Societies of Toxicology (EuroTox)
    • Place of Presentation
      Palais des Congres de Paris, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Establishment of EQSs and Guideline Values for Plastic Resins (vinyl chloride monomer) and Other Hazardous Air Pollutants2011

    • Author(s)
      Kawamoto T, et al
    • Organizer
      The 47^<th> Congress of the European Societies of Toxicology (EuroTox)
    • Place of Presentation
      Palais des Congres de Paris, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Formation of N^2-ethylidene-dG adduct in aldehyde dehydrogenase 2 knockout mice due to ethanol drinking2011

    • Author(s)
      Yu H-S, et al
    • Organizer
      The 47^<th> Congress of the European Societies of Toxicology (EuroTox)
    • Place of Presentation
      Palais des Congres de Paris, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Japan environment and children's study-pilot study and research launch2011

    • Author(s)
      Mori K, et al
    • Organizer
      International Society for Environmental Epidemiology (ISEE) 2011
    • Place of Presentation
      Palau de Congressos de Barcelona, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] International coordination in birth cohorts2011

    • Author(s)
      Mori K, et al
    • Organizer
      International Society for Environmental Epidemiology (ISEE) 2011
    • Place of Presentation
      Palau de Congressos de Barcelona, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] Establishment of Environmental quality standards for hazardous air pollutants2010

    • Author(s)
      Kawamoto T, et al.
    • Organizer
      The 13^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
    • Place of Presentation
      産業医科大学(福岡県)
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effect of ethanol drinking one Aldh2 polymorphism and N2-ethylidene-dGadduct formation in mice : Implication for alcohol-related carcinogenicity for oral and esophagus2010

    • Author(s)
      Yu H-S, et al.
    • Organizer
      The 13^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
    • Place of Presentation
      産業医科大学(福岡県)
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 喫煙と胎児発育制限-胎盤アミノ酸素輸送および妊娠高血圧症候群との関連について-2010

    • Author(s)
      柴田英治, 他
    • Organizer
      日本胎盤学会
    • Place of Presentation
      ホテル日航熊本(熊本県)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Japan Environment and Children's Study (JECS). In a symposium; Longitudinal Birth Cohort Studies in Asia (chaired by Kawamoto T and Chen P-C)2010

    • Author(s)
      Kawamoto T, Tsukamoto N, Tanto M, Nitta H, Murata K, Kayama F, Kishi R, Satoh H
    • Organizer
      ISES-ISEE2010 (2010 Joint Conference of International Society of Exposure Science & International Society for Environmental Epidemiology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] 生物学的モニタリング・バイオマーカー研究会の活動と成果.シンポジウム「有機溶剤中毒・生物学的モニタリング・バイオマーカー研究の未来-産業現場と研究の接点を求めて-2010

    • Author(s)
      川本俊弘、市場正良
    • Organizer
      日本産業衛生学会第38回有機溶剤中毒研究会・第43回生物学的モニタリング・バイオマーカー研究会合同研究会
    • Place of Presentation
      サンプラザ・シーズンズ(名古屋)
    • Related Report
      2012 Final Research Report
  • [Presentation] Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by Gstml, Gsttl, and Aldh2 genotypes2010

    • Author(s)
      Kim YD, et al.
    • Organizer
      ISES-ISEE2010
    • Place of Presentation
      Coex convention center, Seoul(Korea)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Japan environment and children' s study (JECS).In a symposium ; longitudinal birth cohort studies in Asia2010

    • Author(s)
      Kawamoto T, et al.
    • Organizer
      ISES-ISEE2010
    • Place of Presentation
      Coex convention center, Seoul(Korea)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生物学的モニタリング・バイオマーカー研究会の活動と成果 シンポジウム 有機溶剤中毒・生物学的モニタリング・バイオマーカー研究会の未来-産業現場と研究の接点を求めて-2010

    • Author(s)
      川本俊弘, 他
    • Organizer
      日本産業衛生学会第38回有機溶剤中毒研究会・第43回生物学的モニタリング・バイオマーカー研究会 合同研究会
    • Place of Presentation
      サンプラザ・シーズンズ(愛知県)
    • Related Report
      2010 Annual Research Report
  • [Book] Encyclopedia of Environmental Health2011

    • Author(s)
      Nriagu JO, Kacew S, Kawamoto T, Patz JA, Rennie DM.
    • Publisher
      Elsevier, Amsterdam, Netherlands
    • Related Report
      2012 Final Research Report
  • [Book] Encyclopedia of Environmental Health2011

    • Author(s)
      Nriagu JO, et al
    • Publisher
      Elsevier
    • Related Report
      2011 Annual Research Report
  • [Book] III-3 曝露・影響評価と生物学的モニタリング. 分子予防環境医学研究会編: 分子予防環境医学 改訂版2010

    • Author(s)
      川本俊弘
    • Publisher
      (株)本の泉社.東京.改訂版第1刷
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 合成樹脂原料モノマーまたは合成樹脂前駆体への曝露の検出法2011

    • Inventor(s)
      川本俊弘・吉田安宏・一瀬豊日
    • Industrial Property Rights Holder
      産業医科大学
    • Industrial Property Number
      2011-033755
    • Filing Date
      2011-02-18
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 合成樹脂原料モノマーまたは合成樹脂前駆体への曝露の検出方法2011

    • Inventor(s)
      川本俊弘, 他
    • Industrial Property Rights Holder
      産業医科大学
    • Industrial Property Number
      2011-033755
    • Filing Date
      2011-02-18
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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