Investigation on sensitized status to plastic resin materials
| Project/Area Number |
22510036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OYAMA Tsunehiro 産業医科大学, 医学部, 准教授 (00309965)
TANAKA Masayuki 産業医科大学, 医学部, 助教 (80412633)
TSUJI Mayumi 産業医科大学, 医学部, 講師 (40457601)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 健康影響評価 / アレルギー / 樹脂 / プラスチック / 免疫グロブリン / 化学物質 / IgG / 実態調査 / 蛋白質付加体 / ドットブロット |
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| Research Abstract |
This study aimed to verify a hypothesis that recent increase of allergy patients is partly explained by antibodies against plastic resin materials. A new method to detect serum antibodies against plastic resin materials were developed by using western-dot blotting. Among 100 wonlen, the positive rates of IgG against phthalic anhydrate and glutaraldehyde were very high. That against toluene 2,4-diisocyanate was around 50%, and those against bisphenol A diglycidyl ether, P-henylenediamine and formaldehyde were very low. The antibody titers against the causal chemical were related to the severity of allergies. From this study, it is suggested that antibodies against plastic resin materials related the onset of allergies.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism2012
Author(s)
Oyama T, Uramoto H, Kagawa N, Yoshimatsu T, Osaki T, Nakanishi R, Nagaya H, Kaneko K, Muto M, Kawamoto T, Tanaka F, Gotoh A
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Journal Title
Frontiers in Bioscience
Volume: S4
Pages: 1539-1546
Related Report
Peer Reviewed
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[Journal Article] Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice2011
Author(s)
Li Q, Kobayashi M, Inagaki H, Hirata Y, Hirata K, Shimizu T, Wang R-S, Suda M, Kawamoto T, Nakajima T, Kawada T
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Journal Title
International Journal of Immunopathology and Pharmacology
Volume: 24
Pages: 837-847
Related Report
Peer Reviewed
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[Journal Article] Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes2010
Author(s)
Kim YD, Eom SY, Zhang YW, Kim H, Park JD, Yu SD, Lee CH, Arashidani K, Kawamoto T, Kim H
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Journal Title
Human Experimental Toxicology
Volume: 30(4)
Pages: 338-342
Related Report
Peer Reviewed
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[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehaydrogenase deficient mice (Aldh2-/-)2010
Author(s)
Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu H-S, Pham TTP, Tanaka M, Kagawa N, Kanako K, Kawamoto T
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Journal Title
Frontiers in Bioscience E
Volume: 2
Pages: 1344-1354
Related Report
Peer Reviewed
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