Statistical modeling of dose response for the radiation effect analysis
| Project/Area Number |
22510055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hokkaido University |
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Principal Investigator |
DATE Hiroyuki 北海道大学, 大学院・保健科学研究院, 教授 (10197600)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Kaori 北海道大学, 大学院・保健科学研究院, 助教 (80344505)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生物影響 / 放射線作用機構 / 放射線被ばく影響 / 電子線トラック / 二本鎖切断 / 細胞生存率 / 放射線誘起バイスタンダー効果 / 免疫蛍光染色法 / 放射線被曝影響 / 電離・励起クラスター / 非致死確率 |
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| Research Abstract |
The effects of radiation exposure on bio-cells were investigated by the Monte Carlo simulations of electrons and biologically active agents, and by the observation of DNA lesions in cell nuclei using immunofluorescent staining. The simulation study of electrons showed that the electron track structure created by the radiation affects strongly the lesion pattern in a cell. From a model analysis for the cell lethality and the observation of DNA lesions, it was found that the surviving fraction of cells is governed by the lesion number per cell following the Poisson statistics and the repair probabilities of the lesions.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] A Simulation Study of Radiation Therapy Based on LQ Model.2011
Author(s)
Naoki Kishimoto, Yuriko Komiya, Hiroyuki Date, Hiroki Shirato, Masahiro Mizuta.
Organizer
Joint Meeting of the Korea-Japan Conference of Computational Statistics and the 25th Symposium of Japanese Society of Computational Statistics
Place of Presentation
Haeundae Grand Hotel, Busan, Korea.
Related Report
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