Statistical modeling of dose response for the radiation effect analysis

• Project/Area Number: 22510055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Hokkaido University
• Principal Investigator: DATE Hiroyuki 北海道大学, 大学院・保健科学研究院, 教授 (10197600)
• Co-Investigator(Kenkyū-buntansha): TSUTSUMI Kaori 北海道大学, 大学院・保健科学研究院, 助教 (80344505)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生物影響 / 放射線作用機構 / 放射線被ばく影響 / 電子線トラック / 二本鎖切断 / 細胞生存率 / 放射線誘起バイスタンダー効果 / 免疫蛍光染色法 / 放射線被曝影響 / 電離・励起クラスター / 非致死確率

Research Abstract

The effects of radiation exposure on bio-cells were investigated by the Monte Carlo simulations of electrons and biologically active agents, and by the observation of DNA lesions in cell nuclei using immunofluorescent staining. The simulation study of electrons showed that the electron track structure created by the radiation affects strongly the lesion pattern in a cell. From a model analysis for the cell lethality and the observation of DNA lesions, it was found that the surviving fraction of cells is governed by the lesion number per cell following the Poisson statistics and the repair probabilities of the lesions.

Research Products

• [Journal Article] A Simulation Study of the Radiation-Induced Bystander Effect: Modeling with Stochastically Defined Signal Reemission (2012)
  • Author(s): Kohei Sasaki, Kosuke Wakui, Kaori Tsutsumi, Akio Itoh, and Hiroyuki Date
  • Journal Title: Computational and Mathematical Methods in Medicine Volume: 2012 Pages: 5-5
  • DOI: 10.1155/2012/389095
  • NAID: 120005108190
  • Peer Reviewed
• [Journal Article] Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning (2012)
  • Author(s): Masahiro Mizuta, Hiroyuki Date, Seishin Takao, Naoki Kishimoto, Kenneth L. Sutherland, Rikiya Onimaru, and Hiroki Shirato
  • Journal Title: Medical Physics Volume: 39 (11) Issue: 11 Pages: 6791-6795
  • DOI: 10.1118/1.4757580
  • NAID: 120005108216
  • Peer Reviewed
• [Journal Article] A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear-Quadratic Model (2012)
  • Author(s): Mizuta M, Takao S, Date H, Kishimoto N, Sutherland KL, Onimaru R, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(3) Issue: 3 Pages: 829-833
  • DOI: 10.1016/j.ijrobp.2012.01.004
  • NAID: 120005108206
  • Peer Reviewed
• [Journal Article] Electron Track Analysis for Damage Formation in Bio-Cells (2011)
  • Author(s): Y.Yoshii, K.L.Sutherland, H.Date
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 269 Issue: 17 Pages: 1887-1891
  • DOI: 10.1016/j.nimb.2011.05.028
  • Peer Reviewed
• [Journal Article] Radiation-induced Cancer Cell Repopulation: A possible mechanism implied by experiments using trasplantable mouse-derived sarcoma cell line. (2011)
  • Author(s): T. Nishioka, M. Yasuda, T. Takeshima, H.Haga, Y. Miyai, K. Shibata, H. Shirato, M, Teduka and H. Date.
  • Journal Title: Cell Structure and Function Volume: 36 Pages: 13-20
  • Peer Reviewed
• [Journal Article] Electron Track Analysis for Damage Formation in Bio-Cells (2011)
  • Author(s): Y.Yoshii, K.L.Sutherland, H.Date
  • Journal Title: Nuclear Instruments and Methods in Physics Research B Volume: 269 Pages: 1887-1891
  • Peer Reviewed
• [Journal Article] Radiation-induced Cancer Cell Repopulation : A possible mechanism implied by experiments using trasplantable mouse-derived sarcoma cell line (2011)
  • Author(s): T.Nishioka, M.Yasuda, T.Takeshima, H.Haga, Y.Miyai, K.Shibata, H.Shirato, M, Teduka, H.Date
  • Journal Title: Cell Structure and Function Volume: 36 Pages: 13-20
  • Peer Reviewed
• [Presentation] Upcoming Dynamic Real-time Tumor-tracking for Lung Cancer: A Preliminary Study of its Validity. (2013)
  • Author(s): Rie Yamazaki, Seiko Nishioka, Hiroyuki Date, Takao Koike, Hiroki Shirato, Takeshi Nishioka.
  • Organizer: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Sapporo Convention Center, Sapporo, Japan
  • Year and Date: 2013-02-08
• [Presentation] A Mathematical Method for Estimating Optimal Fractionation Regimen in Radiotherapy (2013)
  • Author(s): Seishin Takao, Masahiro Mizuta, Hiroyuki Date, Yuriko Komiya, Kenneth L. Sutherland, Rikiya Onimaru, Hiroki Shirato.
  • Organizer: Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique
  • Place of Presentation: Sapporo Convention Center, Sapporo, Japan
  • Year and Date: 2013-02-08
• [Presentation] Modeling ofRadiation-Induced Bystander Effect with Re-emitting Signals Following the Poisson Statistics. (2012)
  • Author(s): K. Sasaki, H. Date, T. Tsujiguchi, K. Wakui and A. Itoh.
  • Organizer: World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing,China
• [Presentation] Analysis of Cell Surviving Fractionwith Non-Lethal Probability for Radiation Exposure. (2012)
  • Author(s): Kosuke Wakui, Kohei Sasaki, HiroyukiDate.
  • Organizer: World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing, China
• [Presentation] Modeling of Radiation-Induced Bystander Effect with Re-emitting Signals Following the Poisson Statistics (2012)
  • Author(s): Kohei Sasaki
  • Organizer: World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing, China
• [Presentation] Analysis of Cell Surviving Fraction with Non-Lethal Probability for Radiation Exposure (2012)
  • Author(s): Kosuke Wakui
  • Organizer: World Congress on Medical Physics and Biomedical Engineering
  • Place of Presentation: Beijing International Convention Center, Beijing, China
• [Presentation] Theoretical Comparison between Availabilities of Single- and Fractionated- Irradiation Therapies. (2011)
  • Author(s): M. Mizuta, S. Takao, H. Date, N. Kishimoto, H. Shirato.
  • Organizer: ASTRO's (American Society for Radiation Oncology) 53rd Annual Meeting inMiami Beach
  • Place of Presentation: Miami Beach Convention Center, Miami, FL (USA)
  • Year and Date: 2011-10-26
• [Presentation] Microdosimetric Kinetic Analysis of the Relation between Energy Distribution of Photon Beam and Lesions Induced in Bio-Cells. (2011)
  • Author(s): Y. Ohtsubo, K. Tsutsumi, K. Sasaki, K. Wakui, and H. Date.
  • Organizer: The 6th Japan-Korea Joint Meeting on Medical Physics and the 11th Asia-Oceania Congress of Medical Physics.
  • Place of Presentation: Kyushu University (Fukuoka)
  • Year and Date: 2011-09-29
• [Presentation] Modeling of Clustering Properties of the Electron Processes in Bio-Tissues Exposed to Ionizing Radiation. (2011)
  • Author(s): Yuji Yoshii, Kohei Sasaki, K.L. Sutherland, and Hiroyuki Date.
  • Organizer: The 6th Japan-Korea Joint Meeting on Medical Physics and the11th Asia-Oceania Congress of Medical Physics.
  • Place of Presentation: Kyushu University (Fukuoka)
  • Year and Date: 2011-09-29
• [Presentation] Trial Study of a New Model for Cell Surviving Fraction. (2011)
  • Author(s): Kosuke Wakui, Takahiro Kato, Kohei Sasaki and Hiroyuki Date.
  • Organizer: The 6th Japan-Korea Joint Meeting onMedical Physics and the 11th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyushu University (Fukuoka)
  • Year and Date: 2011-09-29
• [Presentation] A Simulation Study of Radiation Therapy Based on LQ Model. (2011)
  • Author(s): Naoki Kishimoto, Yuriko Komiya, Hiroyuki Date, Hiroki Shirato, Masahiro Mizuta.
  • Organizer: Joint Meeting of the Korea-Japan Conference of Computational Statistics and the 25th Symposium of Japanese Society of Computational Statistics
  • Place of Presentation: Haeundae Grand Hotel, Busan, Korea.
• [Presentation] Microdosimetric Kinetic Analysis of the Lesions inBio-Cells by Radiation Exposure. (2011)
  • Author(s): Y. Ohtsubo, K. Tsutsumi, K. Sasaki, K. Wakui, and H. Date.
  • Organizer: PROGRAMME GUIDE & BOOK OF ABSTRACTS of 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: Palace of Culture and Science, Warsaw, Poland
• [Presentation] Computational Approach for Determining the Properties of Low-Energy Electron Track. (2011)
  • Author(s): Y. Yoshii, K. Sasaki, K.L. Sutherland, and H. Date.
  • Organizer: PROGRAMME GUIDE & BOOK OF ABSTRACTS of 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: Palace of Culture and Science, Warsaw, Poland
• [Presentation] Microdosimetric Kinetic Analysis of the Relation between Energy Distribution of Photon Beam and Lesions Induced in Bio-Cells (2011)
  • Author(s): Y.Ohtsubo, K.Tsutsumi, K.Sasaki, K.Wakui, H.Date
  • Organizer: The 6th Japan-Korea Joint Meeting on Medical Physics and the 11th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka, Japan
• [Presentation] Modeling of Clustering Properties of the Electron Processes in Bio-Tissues Exposed to Ionizing Radiation (2011)
  • Author(s): Fuji Yoshii, Kohei Sasaki, K.L.Sutherland, Hiroyuki Date
  • Organizer: The 6th Japan-Korea Joint Meeting on Medical Physics and the 11th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka, Japan
• [Presentation] Trial Study of a New Model for Cell Surviving Fraction (2011)
  • Author(s): Kosuke Wakui, Takahiro Kato, Kohei Sasaki, Hiroyuki Date
  • Organizer: The 6th Japan-Korea Joint Meeting on Medical Physics and the 11th Asia-Oceania Congress of Medical Physics
  • Place of Presentation: Kyusyu University, Fukuoka, Japan
• [Presentation] Microdosimetric Kinetic Analysis of the Lesions in Bio-Cells by Radiation Exposure (2011)
  • Author(s): Y.Ohtsubo, K.Tsutsumi, K.Sasaki, K.Wakui, H.Date
  • Organizer: 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: The Palace of Culture and Science, Warsaw, Poland
• [Presentation] Computational Approach for Determining the Properties of Low-Energy Electron Track (2011)
  • Author(s): Y.Yoshii, K.Sasaki, K.L.Sutherland, H.Date
  • Organizer: 14th International Congress of Radiation Research (ICRR)
  • Place of Presentation: The Palace of Culture and Science, Warsaw, Poland
• [Presentation] An Interpretation of the Survival Curve for Cells Exposed to X-rays. (2010)
  • Author(s): H. Date, T. Kato, K. Wakui.
  • Organizer: 9th International Conference on the Effects of Low and Very Low Doses of Ionizing Radiation on Human Health and Biotopes.
  • Place of Presentation: Escola Universitaria d'Enginyeria Tecnica Industrial de Barcelona, Barcelona, Spain
• [Presentation] Properties of Electron Collisions with Constituent Molecules in Living Cells. (2010)
  • Author(s): H. Date, H. Hasegawa, M. Shimozuma.
  • Organizer: International Workshop on Plasmas with Liquids (IWPL2010)
  • Place of Presentation: Hotel Okudogo, Matsuyama, Ehime, Japan
• [Presentation] 放射線照射下の細胞生存率に関する微視的動態モデル解析 (2010)
  • Author(s): 天庫洋輔, 堤香織, 伊達広行
  • Organizer: 日本医学物理学会第100回大会
  • Place of Presentation: 学術総合センター,東京,日本
• [Presentation] An Interpretation of the Survival Curve for Cells Exposed to X-rays (2010)
  • Author(s): H.Date, T.Kato, K.Wakui
  • Organizer: 9th International Conference on the Effects of Low and Very Low Doses of lonizing Radiation on Human Health and Biotopes
  • Place of Presentation: Escola Universtaria d'Enginyeria Tecnica Industrial de Barcelona, Spain