Novel functions of DNA repair factors: The roles of new XPD complex in the DNA damage responses
| Project/Area Number |
22510061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Osaka University |
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Principal Investigator |
SEKI Mineaki 大阪大学, 生命機能研究科, 助教 (40304167)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 修復 / 損傷 / 応答 / DNA修復 / DNA損傷 / DNA損傷応答 / 鉄硫黄クラスター |
|---|
| Research Abstract |
To understand the mechanisms of genetics disorders caused by compromised nucleotide excision repair system, we started to analyze the roles of novel complex containing XPD in the response to DNA damage. In the course of study, we found another complex functioning in the cytosolic iron-sulfur (Fe-S) cluster assembly pathway. This complex has central roles in the Fe-S cluster assembly in cytosol. Moreover, we also revealed the roles of each component in the complex.
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Report
(4 results)
Research Products
(10 results)
