Elucidation of in vivo repair system for 5-formyluracil termed as FO system
| Project/Area Number |
22510062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Saga University |
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Principal Investigator |
TERATO Hiroaki 佐賀大学, 総合分析実験センター, 准教授 (00243543)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Toshihiro 佐賀大学, 総合分析実験センター, 教務員 (20186852)
TOKUYAMA Yuka 佐賀大学, 総合分析実験センター, 教務員 (30398135)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 修復 / DNA損傷 / 活性酸素 / 修復酵素 / 突然変異 / 放射線 |
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| Research Abstract |
In this study, we focused on elucidation of repair system for 5-formyluracil (5-foU) as a major thymine oxidative lesion. We here assumed the FO system as an integration of multiple repair pathways for 5-foU including the base excision repair, the mismatch repair, and the nucleotide pool sanitization. The result of this study leads the elucidation of 5-foU repair system and also achieves novel technical advance of analytical chemistry for DNA damage.
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Report
(4 results)
Research Products
(31 results)
