Why have nematode a radiation tolerance? :Elucidation of the resistant mechanism.
| Project/Area Number |
22510064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokai University |
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Principal Investigator |
ISHII Naoaki 東海大学, 医学部, 教授 (60096196)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 応答 / ホルミシス効果 / C. elegans / 耐性幼虫 / 放射線傷害 / 寿命 / 線虫 / 耐性機構 / 放射線 / C.elegans / ホルミシス / 遺伝子発現 / マイクロアレイ / 活性酸素 / インスリン・シグナル |
|---|
| Research Abstract |
It is known that nematode shows strong radiation tolerance. In response to harsh environmental conditions, nematode C. elegans larvae undergo dauer stage and recover the normal stage by environmental reform. Modest doses X-irradiation of dauer larvae increased their post-dauer longevity. We founded that the gene expressions of some enzymes of metabolic regulation/anti-oxidation related with metabolic regulation/stress response were up-regulated in the X-ray irradiated dauer larvae. Especially, it is suggested that a transcription factor, mxl-3 plays a role of radiation tolerance
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Asymmetric arginine dimethylation determines life span in C.elegans by regulating forkhead transcription factor DAF-162011
Author(s)
Takahashi Y., Daitoku H., Hirota K., Tamiya H., Yokoyama A., Kako K., Nagashima Y., Nakamura A., Shimada T., Watanabe S., Yamagata K., Yasuda K., Ishii N., Fukamizu A.
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Journal Title
Cell Metabolism
Volume: 13
Issue: 5
Pages: 505-516
DOI
Related Report
Peer Reviewed
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[Journal Article] Radiation Biology of Caenorhabditis elegans: Germ Cell Response, Aging and Behavior2010
Author(s)
Sakashita T, Takanami T, Yanase S, Hamada N, Suzuki M, Kimura T, Kobayashi Y, Ishii N, Higashitani A
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Journal Title
Journal of Radiation Research
Volume: 51
Issue: 2
Pages: 107-121
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
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