Reaction Mechanism of new vitamin E analog for protecting radiation injuries

• Project/Area Number: 22510066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Nihon Pharmaceutical University
• Principal Investigator: ANZAI Kazunori 日本薬科大学, 薬学部, 教授 (70128643)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Kenichiro 放射線医学総合研究所, 重粒子医科学センター, チームリーダー (10297046) ; TAKATA Jiro 福岡大学, 薬学部, 教授 (90122704)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線防護剤 / ビタミンE誘導体 / 骨髄死 / 血球系細胞 / サイトカイン / 経口投与 / 皮下投与 / 放射線かん治療 / 放射線防御

Research Abstract

Several vitamin E analogs were examined against radiation-induced bone marrow death of mice and γ-tocopherol dimethylglycine ester was found to be most effective. It increased the survival of mice after whole body exposure of X-rays or carbon heavy atom radiation. The effect was found to be derived from the increase of the recovery of hematopoietic cells. The compound did not inhibit the control of tumor growth by local carbon heavy atom radiation using mouse xenograft model.

Research Products

• [Journal Article] Nuclear Power Plant accident: facts, environmental contamination, possible biological effects, and countermeasures (2012)
  • Author(s): Kazunori Anzai, Nobuhiko Ban, Toshihiko Ozawa, Shinji Tokonami, Fukushima Daiichi
  • Journal Title: J. Clin. Biochem. Nutr Volume: 50 Pages: 2-8
  • Peer Reviewed
• [Journal Article] Vitamin E-deficiency did not exacerbate patial skin reactions inmice locally irradiated with X-rays (2011)
  • Author(s): Cuiping Chi, Daisuke Hayashi, Masato Nemoto, Minako Nyui, Shiro Urano, Kazunori Anzai
  • Journal Title: J. Radiat. Res Volume: 52 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Fukushima Daiichi Nuclear Power Plant accident: facts, environmental contamination, possible biological effects, and countermeasures (2011)
  • Author(s): Kazunori Anzai, Nobuhiko Ban, Toshihiko Ozawa, Shinji Tokonami
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 50 Issue: 1 Pages: 2-8
  • DOI: 10.3164/jcbn.D-11-00021
  • NAID: 130004466666
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Vitamin E-deficiency did not exacerbate patial skin reactions in mice locally irradiated with X-rays (2011)
  • Author(s): Cuiping Chi, Daisuke Hayashi, Masato Nemoto, Minako Nyui, Shiro Urano, Kazunori Anzai
  • Journal Title: Journal of Radiation Research Volume: 52 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Vascular Homeostasis Regulators, Edn1 and Agpt2, are Upregulated as a Protective Effect of Heat-treated Zinc Yeast in Irradiated Murine Bone Marrow (2010)
  • Author(s): Megumi Ueno, Kaori Imadome, Mayumi Iwakawa, Kazunori Anzai, Nobuo Ikota, Takashi Imai
  • Journal Title: J. Radiat. Res Volume: 51 Pages: 519-525
  • NAID: 10026644260
  • Peer Reviewed
• [Journal Article] Vascular Homeostasis Regulators, Edn1 and Agpt2, are Upregulated as a Protective Effect of Heat-treated Zinc Yeast in Irradiated Murine Bone Marrow (2010)
  • Author(s): Megumi Ueno, Kaori Imadome, Mayumi Iwakawa, Kazunori Anzai, Nobuo Ikota, Takashi Imai
  • Journal Title: Journal of Radiation Research Volume: 51 Pages: 519-525
  • NAID: 10026644260
  • Peer Reviewed
• [Journal Article] Gamma-tocopherol-N,N-dimethylglycine ester as a potent post-irradiation mitigator against total body X-irradiation-induced bone marrow death in mice
  • Author(s): Kazunori Anzai, Megumi Ueno, Ken-ichiro Matsumoto, Nobuo Ikota, Jiro Takata
  • Journal Title: J. Radiat. Res Volume: (in press)
  • Peer Reviewed
• [Presentation] 水溶性ビタミンE誘導体による放射線防護効果 (2012)
  • Author(s): 安西和紀
  • Organizer: 機能性物質による被ばく低減化研究会第1回会合
  • Place of Presentation: 東京
  • Year and Date: 2012-01-26
• [Presentation] Effects of several antioxidants against X-ray-induced thymic lymphoma in mice (2012)
  • Author(s): K. Anzai, M. Ueno, M. Nishimura, Y. Shimada
  • Organizer: Society for Free Radical Research International 16thBiennial Meeting
  • Place of Presentation: London, UK
• [Presentation] 迅速簡便な放射線防護剤スクリーニング法の確立 (2012)
  • Author(s): 関根絵美子、上野恵美、下川卓志、松本謙一郎、中西郁夫、中村悦子、中渡美也子、今井高志、安西和紀、村上 健
  • Organizer: 第65回日本酸化ストレス学会学術集会
  • Place of Presentation: 徳島市
• [Presentation] 重粒子線による正常組織の障害を防護する化合物の開発 (2012)
  • Author(s): 安西和紀、上野恵美
  • Organizer: 平成23年度HIMAC共同利用研究成果発表会
  • Place of Presentation: 千葉市
• [Presentation] 迅速簡便な放射線防護剤スクリーニング法の確立 (2012)
  • Author(s): 関根絵美子、上野恵美、下川卓志、松本謙一郎、中西郁夫、中村悦子、中渡美也子、今井高志、安西和紀、村上 健
  • Organizer: 第65回日本酸化ストレス学会学術集
  • Place of Presentation: 徳島市
• [Presentation] Effects of several antioxidants against X-ray-induced thymic lymphoma in mice (2012)
  • Author(s): K. Anzai, M. Ueno, M. Nishimura, Y. Shimada
  • Organizer: Society for Free Radical Research International 16th Biennial Meeting
  • Place of Presentation: London, UK
• [Presentation] Radiation Modifier: Compounds, which modify radiation injuries (2011)
  • Author(s): Kazunori Anzai
  • Organizer: 中国輻射防護研究院セミナー
  • Place of Presentation: 太原、中華人民共和国
  • Year and Date: 2011-11-24
• [Presentation] Radiation Modifier : Compounds, which modify radiation injuries (2011)
  • Author(s): Kazunori Anzai
  • Organizer: 中国輻射防護研究院セミナー
  • Place of Presentation: 大原、中国
  • Year and Date: 2011-11-24
• [Presentation] Radiation mitigators : Compounds, which are effective when administered immediately after exposure to radiations (2011)
  • Author(s): Kazunori Anzai, Megumi Ueno, Ken-ichiro Matsumoto, Jiro Takata
  • Organizer: The 3rd International Symposium on Radiation Emergency Medicine in Hirosaki University
  • Place of Presentation: Hirosaki, Japan
  • Year and Date: 2011-09-17
• [Presentation] Radical-scavenging activity of 6-chromanol derivatives with various substituents (2011)
  • Author(s): Ikuo Nakanishi, Keiko Imai, Tomonori Kawashima, Kiyoshi Fukuhara, Shunichi Fukuzumi, Kazunori Anzai, Toshihiko Ozawa, Masataka Mochizuki, Ken-ichiro Matsumoto
  • Organizer: SFRBM's 18th Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] γ-Tocopherol-N,N-dimethylglycine ester is a potent radiation mitigator against bone marrow death of mice induced by total body irradiation of X-rays or carbon-beams (2011)
  • Author(s): Kazunori Anzai, Megumi Ueno, Ken-ichiro Matsumoto, Jiro Takata
  • Organizer: 14th International Congress of Radiation Research (ICRR2011)
  • Place of Presentation: Warsaw, Poland
• [Presentation] ビタミンEおよび6-クロマノール誘導体のラジカル消去反応における構造活性相関 (2011)
  • Author(s): 中西郁夫、稲見圭子、大久保 敬、川島知憲、松本謙一郎、福原 潔、奥田晴宏、望月正隆、伊古田暢夫、福住俊一、小澤俊彦、安西和紀
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡市
• [Presentation] 炭素重粒子線によるマウス骨髄死に対する水溶性ビタミンE誘導体の防御効果 (2011)
  • Author(s): 安西和紀、上野恵美、松本謙一郎、高田二郎
  • Organizer: 第22回ビタミンE研究会
  • Place of Presentation: 京都市
• [Presentation] A vitamin E analog (γ-Tocopherol-N,N-dimethylglycine ester) is a potent radiation mitigator against bone marrow death of mice induced by whole body irradiation of X-rays and carbon beams (2011)
  • Author(s): Kazunori Anzai, Megumi Ueno, Nobuo Ikota, Jiro Takata
  • Organizer: International Symposium on Free Radical Research: Contribution to Medicine
  • Place of Presentation: Kyoto, Japan
• [Presentation] Y-Tocopherol-N, N-dimethylglycine ester is a potent radiation mitigator against bone marrow death of mice induced by total body irradiation of X-rays or carbon-beams (2011)
  • Author(s): Kazunori Anzai, Megumi Ueno, Ken-ichiro Matsumoto, Jiro Takata
  • Organizer: 14th International Congress of Radiation Research (ICRR2011)
  • Place of Presentation: Warsaw, Poland
• [Presentation] Radical-scavenging activity of 6-chromanol derivatives with various substituents (2011)
  • Author(s): Ikuo Nakanishi, Keiko Imai, Tomonori Kawashima, Kiyoshi Fukuhara, Shunichi Fukuzumi, Kazunori Anzai, Toshihiko Ozawa, Masataka Mochizuki, Ken-ichiro Matsumoto
  • Organizer: SFRBM's 18th Annual Meeting
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] A vitamin E analog (γ-Tocopherol-N, N-dimethylglycine ester) is a potent radiation mitigator against bone marrow death of mice induced by whole body irradiation of X-rays and carbon beams (2011)
  • Author(s): Kazunori Anzai, Megumi Ueno, Nobuo Ikota, Jiro Takata
  • Organizer: International Symposium on Free Radical Research : Contribution to Medicine
  • Place of Presentation: Kyoto
• [Presentation] γ-Tocopherol-N,N-dimethylglycine ester as an potent post-irradiation radiation mitigator against total body X-irradiation-induced bone marrow death of mice (2010)
  • Author(s): Kazunori Anzai, Megumi Ueno, Nobuo Ikota,Jiro Takata
  • Organizer: SFRRI's XV Biennial Meeting and SFRBM's 17th Annual Meeting
  • Place of Presentation: Orlando, USA
• [Presentation] 密度汎関数計算に基づく新規ビタミンE誘導体の分子設計とラジカル消去活性評価 (2010)
  • Author(s): 中西郁夫、稲見圭子、大久保敬、川島知憲、松本謙一郎、福原潔、奥田晴宏、望月正隆、伊古田暢夫、福住俊一、小澤俊彦、安西和紀
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 横浜市
• [Presentation] γ-Tocopherol-N, N-dimethylglycine ester as an potent post-irradiation radiation mitigator against total body X-irradiation-induced bone marrow death of mice (2010)
  • Author(s): Kazunori Anzai, Megumi Ueno, Nobuo Ikota, Jiro Takata
  • Organizer: SFRRI's XV Biennial Meeting and SFRBM's 17th Annual Meeting
  • Place of Presentation: Orlando, FL, USA
• [Book] 放射線の科学 生体影響および防御と除染 (2012)
  • Author(s): 小澤俊彦、安西和紀、松本謙一郎
  • Total Pages: 109
  • Publisher: 東京化学同人
• [Book] 放射線の科学 生体影響および防御と除染 (2012)
  • Author(s): 小澤俊彦、安西和紀、松本謙一郎
  • Total Pages: 109
  • Publisher: 東京化学同人