エストロゲン活性を有する内分泌撹乱化学物質類の学習記憶能に及ぼす影響評価
| Project/Area Number |
22510069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Yasuko 長崎大学, 医歯薬学総合研究科, 講師 (80291532)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 内分泌かく乱物質 / 内分泌撹乱化学物質 / 植物エストロゲン / 周産期曝露 / 学習記憶 / 中枢神経機能 / ビスフェノール A / ノニルフェノール / 一般活動性 / 情動 / エストロゲン活性 / エストロゲン受容体 |
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| Research Abstract |
We investigated the effects of perinatal exposure to bisphenol A (BPA), nonylphenol (NP) and genistein (GNS) on learning and memory function, general activities and emotionality in male SD offspring rats, using a battery of behavioral tests. Perinatal exposure to NP and GNS specifically improved, but low-dose BPA specifically impaired spatial learning and memory in male offspring rats. These results suggest that the effects to estrogenic endocrine disruptors on learning and memory function correlate to their estrogenic activities.
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Report
(4 results)
Research Products
(12 results)
