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Effect of light and dark dosing time on biological response to environmental chemicals in mice

Research Project

Project/Area Number 22510070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionUniversity of Shizuoka

Principal Investigator

SHIMOI Kayoko  静岡県立大学, 環境科学研究所, 教授 (10162728)

Co-Investigator(Kenkyū-buntansha) SAKAKIBARA Hiroyuki  宮崎大学, 宮崎大学, 准教授 (20403701)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生体リズム / 遺伝子発現 / 脂質代謝 / 遺伝毒性 / ベンツ[a]ピレン / ENU / 時計遺伝子 / 解毒代謝 / ベンツピレン / 細胞周期 / 小核試験 / 日内リズム / DNA付加体
Research Abstract

Any differences in the frequencies of micronucleus induction in peripheral blood reticulocytes(MNRETs) of mice exposed to BaP between light and dark dosing times were not observed. However, the expression of lipid metabolism related genes such as Fasn in liver was dramatically increased in treatment group at ZT15(darkphase). On the other hand, MNRETs of mice treated with ENU at ZT15 were significantly higher than those in mice treated at ZT3 (light phase). The expression of p53-responsible genes such as Cyclin G1 in the bone marrow cells was higher in treatment group at ZT3 than that at ZT15. DNA repair might be promoted at light phase. These results suggest that toxic sensitivity to chemicals is different between the light and dark phase.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (11 results) Book (2 results)

  • [Journal Article] Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors2013

    • Author(s)
      Tsurusaki T., Sakakibara H., Aoshima Y., Yamazaki S., Sakono M. and Shimoi K.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 52 Issue: 3 Pages: 208-214

    • DOI

      10.3164/jcbn.12-127

    • NAID

      130004879328

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors2013

    • Author(s)
      Tsurusaki T., Sakakibara H., Aoshima Y., Yamazaki S., Sakono M. and Shimoi K.
    • Journal Title

      J. Clin. Biol. Nutr.

      Volume: 52 Pages: 208-214

    • NAID

      130004879328

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in micronucleus induction in peripheral blood reticulocytes of mice exposed to <i>N</i>-ethyl-<i>N</i>-nitrosourea at light and dark dosing times2012

    • Author(s)
      Itoh K, Masumori S, Nakajima M, Hayashi M, Sakakibara H, and Shimoi K, J.
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 37 Issue: 2 Pages: 427-430

    • DOI

      10.2131/jts.37.427

    • NAID

      10030127086

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Animal Care Procedures on Plasma Corticosterone Levels in Group-Housed Mice during the Nocturnal Active Phase2010

    • Author(s)
      Sakakibara H., Koyanagi A., Suzuki T., Suzuki A., Lin L., Shimoi, K
    • Journal Title

      Experimental Animals

      Volume: 59 Issue: 5 Pages: 637-642

    • DOI

      10.1538/expanim.59.637

    • NAID

      130000419259

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Animal Care Procedures on Plasma Corticosterone Levels in Group-housed Mice during the Nocturnal Active Phase2010

    • Author(s)
      Sakakibara H, Koyanagi A, Suzuki T, Suzuki A, Lin L., Shimoi, K.
    • Journal Title

      Experimental Animals

      Volume: 59 Pages: 637-642

    • NAID

      130000419259

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Different micronucleus induction in mice exposed to N-ethyl-N-nitrosourea at light and dark dosing times2013

    • Author(s)
      Itoh K., Masumori S., NakajimaM., Hayashi M., Sakakibara H.,Shimoi K.
    • Organizer
      52nd Society of Toxicology
    • Place of Presentation
      San Antonio, Texas, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 化学物質の毒性発現に関する時間生物学的アプローチ2012

    • Author(s)
      伊藤圭一、原のりこ、大塚好美、榊原啓之、益森勝志、中嶋 圓、林 真、下位香代子
    • Organizer
      変異機構研究会・第25回夏の学校
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ベンゾ[a]ピレンの投与 時刻の違いによる脂質代謝への影響2012

    • Author(s)
      大塚好美、原のりこ、山崎隼輔、伊藤圭一、 下位香代子
    • Organizer
      富士山麓アカデミック&サイエンスフェア 2012
    • Place of Presentation
      富士
    • Related Report
      2012 Final Research Report
  • [Presentation] 環境化学物質の毒性影響は曝露する時間により異なるのか2011

    • Author(s)
      原のりこ、榊原啓之、小柳顯陽、青島良輝、山崎隼輔、下位香代子
    • Organizer
      富士山麓アカデミック&サイエンスフェア2011
    • Place of Presentation
      ふじさんめっせ(富士市)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 化学物質に対する生体応答は投与時間によって異なるか2011

    • Author(s)
      原のりこ、榊原啓之、小柳顯陽、青島良輝、山崎隼輔、下位香代子
    • Organizer
      第12回静岡ライフサイエンスシンポジウム
    • Place of Presentation
      静岡県立大学(静岡市)
    • Year and Date
      2011-03-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化学物質に対する生体応答は投与時間によって異なるか2011

    • Author(s)
      原のりこ、榊原啓之、小柳顯陽、青島良輝、山崎隼輔、下位香代子
    • Organizer
      第12回静岡ライフサイエンスシンポジウム
    • Place of Presentation
      静岡県立大学(静岡)
    • Related Report
      2012 Final Research Report
  • [Presentation] サーカディアンリズムと遺伝毒性-ベンゾ[a]ピレンによる小核試験に対する投与時刻の影響-2011

    • Author(s)
      原のりこ、榊原啓之、小柳顯陽、青島良輝、山崎隼輔、下位香代子
    • Organizer
      日本環境変異原学会第40回大会
    • Place of Presentation
      学術総合センター(東京)
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 環境化学物質の代謝に関与する遺伝子の日内発現リズム2010

    • Author(s)
      原のりこ、榊原啓之、小柳顯陽、青島良輝、 山崎隼輔、 下位香代子
    • Organizer
      富士山麓アカデミック&サイエンスフェア 2010
    • Place of Presentation
      キラメッセぬまづ(沼津)
    • Year and Date
      2010-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 環境化学物質の代謝に関与する遺伝子の日内発現リズム2010

    • Author(s)
      原のりこ、榊原啓之、小柳顯陽、青島良輝、山崎隼輔、下位香代子
    • Organizer
      富士山麓アカデミック&サイエンスフェア2010
    • Place of Presentation
      キラメッセぬまづ(沼津市)
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] ベンゾ[a]ピレンの投与時刻の違いによる脂質代謝への影響

    • Author(s)
      大塚好美、原のりこ、山崎隼輔、伊藤圭一、下位香代子
    • Organizer
      富士山麓アカデミック&サイエンスフェア2012
    • Place of Presentation
      富士
    • Related Report
      2012 Annual Research Report
  • [Presentation] Different micronucleus induction in mice exposed to N-ethyl-N-nitrosourea at light and dark dosing times

    • Author(s)
      Itoh K., Masumori S., NakajimaM., Hayashi M., Sakakibara H.,Shimoi K.
    • Organizer
      52nd Society of Toxicology
    • Place of Presentation
      San Antonio, Texas, USA
    • Related Report
      2012 Annual Research Report
  • [Book] 外部刺激に対する生体応答を評価するために-夜行性のマウスを用いた時間生物学的アプローチ-、谷本学校毒性質問箱13 号2011

    • Author(s)
      榊原啓之、小柳顯陽、青島良輝、鈴木敬明、木村昌由美、下位香代子
    • Publisher
      サイエンティスト社(東京)
    • Related Report
      2012 Final Research Report
  • [Book] 谷本学校毒性質問箱第13号外部刺激に対する生体応答を評価するために-夜行性のマウスを用いた時間生物学的アプローチ-2011

    • Author(s)
      榊原啓之、小柳顯陽、青島良輝、鈴木敬明、木村昌由美、下位香代子
    • Publisher
      サイエンティスト社(東京)(総説)
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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