| Project/Area Number |
22510071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nihon Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Nariaki 広島大学, 原爆放射線医科学研究所 (40243612)
SUGIHARA Kazumi 広島国際大学, 薬学部 (20271067)
KOJIMA Hiroyuki 北海道道立衛生研究所 (10414286)
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| Co-Investigator(Renkei-kenkyūsha) |
KASHIWAGI Akihiko 広島大学, 理学研究科 (50106796)
URAMARU Naoto 日本薬科大学, 薬学部 (90424069)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ブロム化難燃剤 / 内分泌撹乱 / 代謝的活性化 / 水酸化代謝物 / 甲状腺ホルモン / 核内受容体 / プロテインジスルフィッドイソメラーゼ / 甲状腺ホルモン撹乱 / 核内レセプター / プロテインジスルフィドイソメラーゼ |
|---|
| Research Abstract |
Some brominated flame retardants were converted to the active metabolites which are related structures to thyroid hormone. These active metabolites showed higher affinity to thyroid hormone receptor and related nuclear receptors, and inhibited thyroid hormone dependent protein function-regulating factor, protein disulfide isomerase and thyroid hormonal level-regulating factor, iodotyronine deionidase.
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