Determination of targets for thyroid hormone disruption by brominated flame retardants
| Project/Area Number |
22510071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nihon Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Nariaki 広島大学, 原爆放射線医科学研究所 (40243612)
SUGIHARA Kazumi 広島国際大学, 薬学部 (20271067)
KOJIMA Hiroyuki 北海道道立衛生研究所 (10414286)
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| Co-Investigator(Renkei-kenkyūsha) |
KASHIWAGI Akihiko 広島大学, 理学研究科 (50106796)
URAMARU Naoto 日本薬科大学, 薬学部 (90424069)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ブロム化難燃剤 / 内分泌撹乱 / 代謝的活性化 / 水酸化代謝物 / 甲状腺ホルモン / 核内受容体 / プロテインジスルフィッドイソメラーゼ / 甲状腺ホルモン撹乱 / 核内レセプター / プロテインジスルフィドイソメラーゼ |
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| Research Abstract |
Some brominated flame retardants were converted to the active metabolites which are related structures to thyroid hormone. These active metabolites showed higher affinity to thyroid hormone receptor and related nuclear receptors, and inhibited thyroid hormone dependent protein function-regulating factor, protein disulfide isomerase and thyroid hormonal level-regulating factor, iodotyronine deionidase.
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Report
(4 results)
Research Products
(128 results)
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[Journal Article] Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues2013
Author(s)
Ozaki H., Sugihara K., WatanabeY., Fujino C., Uramaru N., Sone T., Ohta S., Kitamura S
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Journal Title
Xenobiotica
Volume: (in press)
Issue: 12
Pages: 1064-1072
DOI
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Peer Reviewed
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[Journal Article] Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes2012
Author(s)
Sanoh S., Horiguchi A., Sugihara K., Kotake Y., Tayama Y., Uramaru N., Ohshita H., Tateno C., Horie T., Kitamura S., Ohta S
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Journal Title
Drug Metab Dispos
Volume: 40(2)
Issue: 2
Pages: 2267-2272
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats2012
Author(s)
Yao, H. T., Chang, Y. W., Uramaru, N., Watanabe, Y.,. Kitamura, S.,Kuo, Y. H., Lii, C.K., Yeh, T.K
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Journal Title
J. Ethnopharmacol
Volume: 142(1)
Pages: 121-128
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[Presentation] ヒト肝細胞移植キメラマウスにおけるアロメトリックスケーリングを用いたヒト体内動態予測の検証2013
Author(s)
藤本真美, 佐能正剛, 成富洋一, 佐藤公也, 河村章生, 堀口彩, 杉原数美, 立野知世, 堀江透, 北村繁幸, 太田茂
Organizer
日本薬学会第133 年会
Place of Presentation
横浜
Related Report
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[Presentation] Prediction of human pharmacokinetics by allometric scaling using chimeric mice with humanized liver2012
Author(s)
Sanoh S., Naritomi Y., Sato K., Kawamura A., Horiguchi A., Sugihara K., Tateno C., Horie T., Kitamura S., Ohta S
Organizer
19th International Symposium on Microsomes and Drug Oxidations 12th European Regional ISSX Meeting
Place of Presentation
Noordwijk aan Zee, Netherlands
Related Report
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[Presentation] ヒト肝細胞移植キメラマウスにおけるアロメトリックスケーリングを用いたヒト血中動態予測性の検証2012
Author(s)
藤本真美, 佐能正剛, 成富洋一, 佐藤公也, 河村章生, 堀口彩, 杉原数美, 立野知世, 堀江透, 北村繁幸, 太田茂
Organizer
日本薬物動態学会第27回年会
Place of Presentation
千葉
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