Pathogenesis of newly described developmental abnormality induced in the kidney of rhesus monkey offspring by in utero and lactational e xposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

• Project/Area Number: 22510073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Teikyo University
• Principal Investigator: FUKUSATO Toshio 帝京大学, 医学部, 教授 (50134531)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Shunichirou 東京大学, 大学院・総合文化研究科, 教授 (00260480) ; KONDO Fukuo 帝京大学, 医学部, 教授 (80186858) ; TAKAHASHI Yoshihisa 帝京大学, 医学部, 准教授 (70334381)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 内分泌かく乱物質 / ほ乳類 / ダイオキシン / TCDD / 腎形成異常 / dysplasia / sox2 / prostaglandin / 次世代 / 腎 / 形成異常 / ダイオキシン(TCDD) / 腎病変 / 腎尿細管 / レニン・アンギオテンシン系

Research Abstract

We for the first time described developmental abnormality with renal dysplasia induced in the kidney of rhesus monkey offspring exposed during prenatal and lactational period to TCDD. The renal lesions developed exclusively in offspring of dams exposed to relatively high dose (300ng/kg) of TCDD. We disclosed disturbed cox2-prostaglandin system as pathogenesis of the renal lesion.

Research Products

• [Journal Article] Enhanced expression of cox2 and cyp1a1 in early active renal lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during gestation and lactation (2012)
  • Author(s): Toshio Fukusato, Masato Watanabe,Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka, Hiroshi Sumida, Mineo Yasuda
  • Journal Title: Organohalogen Compounds Volume: 74 Pages: 989-992
  • Peer Reviewed
• [Journal Article] Enhanced expression of cox2 and cyp1A1 in early active lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorobenzo-p-dioxin (TCDD) during gestation and lactation (2012)
  • Author(s): Toshio Fukusato
  • Journal Title: Organohalogen Compounds Volume: 74 Pages: 989-992
  • Peer Reviewed
• [Journal Article] Gestational and lactational exposure to2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces abnormal development of the kidney in offspring of rhesus monkeys (2011)
  • Author(s): Masato Watanabe, Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka,Hiroshi Sumida, Mineo Yasuda, Toshio Fukusato
  • Journal Title: Organohalogen Compounds Volume: 73 Pages: 1480-148
  • Peer Reviewed
• [Journal Article] Gestational and Lactational Exposure to 2,3,7,8-tetrachlorodibenzo-p-Dioxin (TCDD) Induces Abnormal Development of the Kidney in Offspring of Rhesus Monkeys (2011)
  • Author(s): Shunichiro Kubota, Toshio Fukusato
  • Journal Title: Organohalogen Compounds Volume: 73 Pages: 1480-1482
  • Peer Reviewed
• [Journal Article] In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)induces disruption of glands of theprostate and fibrosis in rhesus monkeys (2010)
  • Author(s): Akihiro Arima, Hirohito Kato , Ryota Ise , Yojiro Ooshima , Ayumi Inoue , Atsunobu Muneoka , Shunichi Kamimura, Toshio Fukusato, Shunichiro Kubota, Hiroshi Sumida, Mineo Yasuda
  • Journal Title: Reproductive Toxicology Volume: 29 Pages: 317-322
  • Peer Reviewed
• [Journal Article] In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces disruption of glands of the prostate and fibrosis in rhesus monkeys. (2010)
  • Author(s): Toshio Fukusato, Shunichiro Kubota
  • Journal Title: Reproductive Toxicology Volume: 29 Pages: 317-322
  • Peer Reviewed
• [Presentation] Enhanced expression of cox2 and cyp1a1 in early active renal lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during gestation and lactation (2012)
  • Author(s): Toshio Fukusato, Masato Watanabe,Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka, Hiroshi Sumida, Mineo Yasuda
  • Organizer: 32nd International Symposium on Halogenated Persistent Organic Pollutants-Dioxin 2012
  • Place of Presentation: Cairns, Australia
• [Presentation] ダイオキシンの胎生期および授乳期暴露後の仔アカゲザル腎におけるCox2、CYP1A1、HSP70 の発現 (2012)
  • Author(s): 渡邉雅人、高橋芳久、有馬昭宏、宗岡篤信、墨田 寛、安田峯生、 久保田俊一郎、福里利夫
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] ダイオキシンの胎生期および授乳期暴露後の仔アカゲザル腎におけるCox2、CYP1A1、HSP70の発現 (2012)
  • Author(s): 福里利夫、高橋芳久、久保田俊一郎
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] Enhanced expression of cox2 and cyp1A1 in early active lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorobenzo-p-dioxin (TCDD) during gestation and lactation (2012)
  • Author(s): Toshio Fukusato
  • Organizer: 32nd International Symposium on Halogenated Persistent Organic Pollutants–Dioxin 2012
  • Place of Presentation: Australia
• [Presentation] ダイオキシンによる次世代アカゲザルの腎形成異常とCD10免疫染色 (2011)
  • Author(s): 渡邉雅人、高橋芳久、近藤福雄、福里利夫、有馬昭宏、宗岡篤信、隅田寛、安田峯生、久保田俊一郎
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) induces abnormaldevelopment of the kidney in offspring of rhesus monkeys (2011)
  • Author(s): Masato Watanabe, Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka,Hiroshi Sumida, Mineo Yasuda, Toshio Fukusato
  • Organizer: 31st International Symposium on Halogenated Persistent Organic Pollutants - Dioxin 2011
  • Place of Presentation: Brussels, Belgium
• [Presentation] ダイオキシンによる次世代アカゲザルの腎形成異常とCD10免疫染色 (2011)
  • Author(s): 高橋芳久、久保田俊一郎、福里利夫
  • Organizer: 日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] GESTATIONAL AND LACTATIONAL EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD) INDUCES ABNORMAL DEVELOPMENT OF THE KIDNEY IN OFFSPRING OF RHESUS MONKEYS (2011)
  • Author(s): Shunichiro Kubota, Toshio Fukusato
  • Organizer: DIOXIN 2011 (31st International Symposium on Halogenated Persistent Organic Pollutants POPs' Science)
  • Place of Presentation: Brussels, Belgium