Pathogenesis of newly described developmental abnormality induced in the kidney of rhesus monkey offspring by in utero and lactational e xposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
| Project/Area Number |
22510073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Shunichirou 東京大学, 大学院・総合文化研究科, 教授 (00260480)
KONDO Fukuo 帝京大学, 医学部, 教授 (80186858)
TAKAHASHI Yoshihisa 帝京大学, 医学部, 准教授 (70334381)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 内分泌かく乱物質 / ほ乳類 / ダイオキシン / TCDD / 腎形成異常 / dysplasia / sox2 / prostaglandin / 次世代 / 腎 / 形成異常 / ダイオキシン(TCDD) / 腎病変 / 腎尿細管 / レニン・アンギオテンシン系 |
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| Research Abstract |
We for the first time described developmental abnormality with renal dysplasia induced in the kidney of rhesus monkey offspring exposed during prenatal and lactational period to TCDD. The renal lesions developed exclusively in offspring of dams exposed to relatively high dose (300ng/kg) of TCDD. We disclosed disturbed cox2-prostaglandin system as pathogenesis of the renal lesion.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)induces disruption of glands of theprostate and fibrosis in rhesus monkeys2010
Author(s)
Akihiro Arima, Hirohito Kato , Ryota Ise , Yojiro Ooshima , Ayumi Inoue , Atsunobu Muneoka , Shunichi Kamimura, Toshio Fukusato, Shunichiro Kubota, Hiroshi Sumida, Mineo Yasuda
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Journal Title
Reproductive Toxicology
Volume: 29
Pages: 317-322
Related Report
Peer Reviewed
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[Presentation] Enhanced expression of cox2 and cyp1a1 in early active renal lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during gestation and lactation2012
Author(s)
Toshio Fukusato, Masato Watanabe,Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka, Hiroshi Sumida, Mineo Yasuda
Organizer
32nd International Symposium on Halogenated Persistent Organic Pollutants-Dioxin 2012
Place of Presentation
Cairns, Australia
Related Report
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[Presentation] Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) induces abnormaldevelopment of the kidney in offspring of rhesus monkeys2011
Author(s)
Masato Watanabe, Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka,Hiroshi Sumida, Mineo Yasuda, Toshio Fukusato
Organizer
31st International Symposium on Halogenated Persistent Organic Pollutants - Dioxin 2011
Place of Presentation
Brussels, Belgium
Related Report
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