Mechanism of photomutagenicity of UV-irradiated environmental chemicals
| Project/Area Number |
22510075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
OHTA Toshihiro 東京薬科大学, 生命科学部, 教授 (10266893)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 光遺伝毒性 / 変異原性 / 紫外線 / 環境化学物質 / たばこタール / 環境科学物質 |
|---|
| Research Abstract |
Photomutagenic activity of cigarette smoke condensate (CSC) with UVA-irradiation was investigated. Sidestream CSC was more photomutagenic than mainstream CSC. Photomutagenic potency was not related to the tar contents of cigarette. No significant increase of 8-OHdG was detected under the conditions used. Tobacco specific nitrosamins (TSNA) may be responsible for the photomutagenicity.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] Miscoding properties of 8-chloro-2'-deoxyguano- sine, hypochlorous acid-induced DNA adduct, catalyzed by human DNA polymerases2013
Author(s)
Sassa, A., N. Kamoshita, T. Matsuda, I. Kuraoka, T. Ohta, T. Nohmi, M. Honma, and M. Yasui
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Journal Title
Mutagenesis
Volume: 28
Pages: 81-88
Related Report
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[Journal Article] Role of alkyltrans- ferase-like (ATL) protein in repair of methylated DNA lesions in Thermus thermophilus2011
Author(s)
Onodera, T., Morino, K., Tokishita, S., Morita, R., Masui, R., Kuramitsu, S., and Ohta, T.
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Journal Title
Mutagenesis
Volume: 26
Pages: 303-308
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