Host risk factors for bioaccumulation of oral cadmium in life-stage and lifestyle
| Project/Area Number |
22510077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
MIN Kyong-son 大阪大谷大学, 薬学部, 教授 (60140406)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ライフステージ / 経口摂取カドミウム / 必須金属トランスポーター / リスクファクター / 欠食減食 / 生活習慣 / 運動負荷 / 経口カドミウム / 体内蓄積 / 鉄輸送系 / 炎症 / カドミウム / 必須金属代謝 / 食餌性必須金属欠乏 |
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| Research Abstract |
We found some host risk factors for significant increase in bioaccumulation of oral cadmium in life-stage and lifestyle using mice. Pregnancy and lactation increased renal accumulation of oral cadmium in female mice. Moreover, essential metal deficiency such as calcium and iron at a period of growth and vigorous exercise also increased its renal accumulation. An increase in bioaccumulation of oral cadmium may be involved with intestinal expression of essential metal transporters.
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Report
(4 results)
Research Products
(9 results)
