The development of degradation methods of signal compounds in bacterial cell-cell communication mechanism for the inhibition of the biofilm formation

• Project/Area Number: 22510081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental technology/Environmental materials
• Research Institution: Utsunomiya University
• Principal Investigator: IKEDA Tsukasa 宇都宮大学, 大学院・工学研究科, 教授 (40151295)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: バイオフィルム / バクテリア / 細胞間情報伝達機構 / クォーラムセンシング / ア シル化ホモセリンラクトン / 阻害剤 / アシル化ホモセリンラクトン分解酵素 / 遺伝子発現制御 / N-アシル-L-ホモセリンラクトン / AHL分解酵素 / AHL分解酵 / バイオフィル / N-アシル-L-ホモセリンラクトン(AHL)

Research Abstract

The inhibitory methods of bacterial cell-cell communication mechanism regulates a biofilm formation have been developed for the inhibition of the biofilm formation which causes a lot of environmental and medical problems. Various natural enzymes degrade signal compounds in bacterial cell-cell communication mechanism has been obtained and their usefulness for the inhibition of the biofilm formation has been confirmed. Moreover, the new chemical methods for the trap and/or degrade signal compounds in bacterial cell-cell communication mechanism have been also developed and their usefulness for the inhibition of the biofilm formation has been also confirmed.

Research Products

• [Journal Article] AidC, a novel N-acylhomoserine lactonase from the potato root-associated Cytophaga- Flavobacteria-Bacteroides (CFB) group bacterium, Chryseobacterium sp. strain StRB126, Appl (2012)
  • Author(s): W. Z. Wang, T. Morohoshi, N. Someya, and T. Ikeda
  • Journal Title: Environ. Microbiol Volume: 78 Issue: 22 Pages: 7985-7992
  • DOI: 10.1128/aem.02188-12
  • Peer Reviewed
• [Journal Article] Diversity and Distribution of <i>N</i>-Acylhomoserine Lactone (AHL)-Degrading Activity and AHL-Lactonase (AiiM) in Genus <i>Microbacterium</i> (2012)
  • Author(s): W. Z. Wang, T. Morohoshi, N. Someya, and T. Ikeda
  • Journal Title: Microbes and Environments Volume: 27 Issue: 3 Pages: 330-333
  • DOI: 10.1264/jsme2.ME11341
  • NAID: 10030869773
  • ISSN: 1342-6311, 1347-4405
  • Peer Reviewed
• [Journal Article] Complete genome sequence and characterization of the N-acylhomoserine lactone-degrading gene of the potato leaf-associated Solibacillus silvestris (2012)
  • Author(s): T. Morohoshi, Y. Tominaga, N. Someya, and T. Ikeda
  • Journal Title: J. Biosci. Bioeng Volume: 113 Issue: 1 Pages: 20-25
  • DOI: 10.1016/j.jbiosc.2011.09.006
  • NAID: 110008897347
  • Peer Reviewed
• [Journal Article] Genetic Diversity and Ecological Evaluation of Fluorescent Pseudomonads Isolated from the Leaves and Roots of Potato Plants (2012)
  • Author(s): N. Someya, T. Morohoshi, T. Ikeda, K.Tsuchiya, and S. Ikeda
  • Journal Title: Microbes and Environments Volume: 27 Issue: 2 Pages: 122-126
  • DOI: 10.1264/jsme2.ME11237
  • NAID: 10030431689
  • ISSN: 1342-6311, 1347-4405
  • Peer Reviewed
• [Journal Article] A patient with pseudochromhidrosis presenting with pink nails (2012)
  • Author(s): K. Harada, T. Morohoshi, T. Ikeda, and S. Shimada
  • Journal Title: J. Am. Acad. Dermatol Volume: 67 Issue: 2 Pages: e74-e75
  • DOI: 10.1016/j.jaad.2011.08.026
  • Peer Reviewed
• [Journal Article] β-Cyclodextrin interaction with N-hexanoyl homoserine lactone as quorum sensing signal produced in gram-negative bacteria (2012)
  • Author(s): C. Okano, et al.
  • Journal Title: Trans. Mater. Res. Soc. Jpn. Volume: 37 Pages: 315-318
  • Peer Reviewed
• [Journal Article] Inhibitory effects of quorum sensing in Serratia marcescens AS-1 by electrospun polyvinyl alcohol fibers immobilized with cyclodextrin (2012)
  • Author(s): E. Nasuno, et al.
  • Journal Title: Trans. Mater. Res. Soc. Jpn. Volume: 37 Pages: 593-596
  • Peer Reviewed
• [Journal Article] Cell aggregation is negatively regulated by N-acylhomoserine lactone-mediated quorumsensing in Pantoea ananatis SK-1 (2011)
  • Author(s): T.Morohoshi, Y.Ogata, T.Ikeda
  • Journal Title: J.Biosci.Bioeng. Volume: 112 Issue: 6 Pages: 566-569
  • DOI: 10.1016/j.jbiosc.2011.08.004
  • NAID: 110008897330
  • Peer Reviewed
• [Journal Article] Isolation and characterization of novel lipases from a metagenomic library of the microbial community in pitcher fluid of the carnivorous plant Nepenthes hybrid (2011)
  • Author(s): T. Morohoshi, M. Oikawa, S. Sato, N.Kikuchi, N. Kato, and T. Ikeda
  • Journal Title: J. Biosci. Bioeng Volume: 112 Issue: 4 Pages: 315-320
  • DOI: 10.1016/j.jbiosc.2011.06.010
  • Peer Reviewed
• [Journal Article] Exopolysaccharide Production Is Influenced by Sugars, N-Acylhomoserine Lactone, and Transcriptional Regulators RcsA and RcsB, but Does Not Affect Pathogenicity in the Plant Pathogen Pantoea ananatis (2011)
  • Author(s): T.Morohoshi, K.Oseki, T.Ikeda
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 75 Issue: 5 Pages: 997-999
  • DOI: 10.1271/bbb.100888
  • NAID: 10028273007
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Genome sequence ofMicrobacterium testaceum StLB037, an N-acylhomoserine lactone-degrading bacterium isolated from the potato leaves (2011)
  • Author(s): T. Morohoshi, W. Z. Wang, N. Someya, and T. Ikeda
  • Journal Title: J. Bacteriol Volume: 193 Issue: 8 Pages: 2072-2073
  • DOI: 10.1128/jb.00180-11
  • Peer Reviewed
• [Journal Article] Degradation of N-Acylhomoserine Lactone Quorum Sensing Signaling Molecules by Potato Root Surface-Associated Chryseobacterium Strains (2011)
  • Author(s): R. Rashid, T. Morohoshi, N. Someya, and T. Ikeda
  • Journal Title: Microbes and Environments Volume: 26 Issue: 2 Pages: 144-148
  • DOI: 10.1264/jsme2.ME10207
  • NAID: 10029122866
  • ISSN: 1342-6311, 1347-4405
  • Peer Reviewed
• [Journal Article] Diversity of Culturable Chitinolytic Bacteria from Rhizospheres of Agronomic Plants in Japan (2011)
  • Author(s): N. Someya, S. Ikeda, T. Morohoshi, M.Noguchi-Tsujimoto, T. Yoshida, H. Sawada, T. Ikeda, and K. Tsuchiya
  • Journal Title: Microbes and Environments Volume: 26 Issue: 1 Pages: 7-14
  • DOI: 10.1264/jsme2.ME10149
  • NAID: 10028098636
  • ISSN: 1342-6311, 1347-4405
  • Peer Reviewed
• [Journal Article] The Pseudomonas aeruginosa quorum sensing signal N-(3-oxododecanoyl) homoserine lactone can accelerate cutaneous wound healing through myofibroblast differentiation in rats (2011)
  • Author(s): G. Nakagami, T. Minematsu, M. Asada, T.Nagase, T. Akase, L. Huang, T. Morohoshi, T. Ikeda, Y. Ohta, and H. Sanada
  • Journal Title: FEMS Immunol. Med. Microbiol Volume: 62 Issue: 2 Pages: 157-163
  • DOI: 10.1111/j.1574-695x.2011.00796.x
  • Peer Reviewed
• [Journal Article] Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in pressure ulcer infection in rats (2011)
  • Author(s): G. Nakagami, T. Morohoshi, T. Ikeda, Y.Ohta, H. Sagara, L. Huang, T. Nagase, J. Sugama, H. Sanada
  • Journal Title: Wound Repair Regen Volume: 19 Issue: 2 Pages: 214-222
  • DOI: 10.1111/j.1524-475x.2010.00653.x
  • NAID: 10031181734
  • Peer Reviewed
• [Journal Article] AiiM, a novelclass of N-acylhomoserine lactonase from the leaf-associated bacterium Microbacterium testaceum (2010)
  • Author(s): W. Z. Wang, T. Morohoshi, M. Ikenoya, N. Someya, and T. Ikeda
  • Journal Title: Appl. Environ. Microbiol Volume: 76 Issue: 8 Pages: 2524-2530
  • DOI: 10.1128/aem.02738-09
  • Peer Reviewed
• [Journal Article] Regulation of the Violacein Biosynthetic Gene Cluster by Acylhomoserine Lactone-Mediated Quorum Sensing in Chromobacterium violaceum ATCC 12472 (2010)
  • Author(s): T. Morohoshi, K. Fukamachi, M. Kato, N.Kato, and T. Ikeda
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 74 Issue: 10 Pages: 2116-2119
  • DOI: 10.1271/bbb.100385
  • NAID: 10027560835
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Piecewise affine systems approach to control of biological networks (2010)
  • Author(s): J. Imura, K. Kashima, M. Kusano, T.Ikeda, and T. Morohoshi
  • Journal Title: Phil. Trans. R. Soc. A Volume: 368 Issue: 1930 Pages: 4977-4993
  • DOI: 10.1098/rsta.2010.0176
  • Peer Reviewed
• [Journal Article] AiiM, a novel class of N-acylhomoserine lactonase from the leaf-associated bacterium Microbacterium testaceum (2010)
  • Author(s): W-Z.Wang, T.Morohoshi, M.Ikenoya, N.Someya, T.Ikeda
  • Journal Title: Appl.Environ.Microbiol. Volume: 76 Pages: 2524-2530
  • Peer Reviewed
• [Journal Article] Regulation of the violacein biosynthetic gene cluster by acylhomoserine lactone-mediated auorum sensing in Chromobacterium violaceum ATCC 12472 (2010)
  • Author(s): T.Morohoshi, K.Fukamachi, M.Kato, N.Kato, T.Ikeda
  • Journal Title: Biosci.Biotech.Biochem. Volume: 74 Pages: 2116-2119
  • Peer Reviewed
• [Journal Article] Piecewise affine systems approach to control of biological networks (2010)
  • Author(s): J.Imura, K.Kashima, M.Kusano, T.Ikeda, T.Morohoshi
  • Journal Title: Phil.Trans.R.Soc. Volume: 368 Pages: 4977-4993
  • Peer Reviewed
• [Presentation] 水回りに発生するピンクぬめり構成細菌によるバイオフィルム形成の解析 (2013)
  • Author(s): 諸星知広、他
  • Organizer: 日本農芸化学会2013年度大会
  • Place of Presentation: 東北大学
• [Presentation] Quorum Sensing阻害効果の向上を目指したシクロデキストリン誘導体の合成 (2012)
  • Author(s): 斉藤悠生, 他
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応義塾大学
  • Year and Date: 2012-03-25
• [Presentation] ジャガイモ由来Pseudomonas chlororapbis subsp.aurantiacaにおけるフェナジン生産およびクオラムセンシングの解析 (2012)
  • Author(s): 諸星知広, 他
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-23
• [Presentation] 微生物コミュニケーション機構における医・農・工・大学間連携応用研究 (2012)
  • Author(s): 池田宰
  • Organizer: 医工連携セミナー
  • Place of Presentation: 新都心ビジネス交流プラザ
  • Year and Date: 2012-03-13
• [Presentation] 微生物コミュニケーション機構における医・農・工・大学間連携応用研究 (2012)
  • Author(s): 池田宰
  • Organizer: 医工連携セミナー
  • Place of Presentation: 新都心ビジネス交流プラザ(招待講演)
  • Year and Date: 2012-03-13
• [Presentation] Quorum Sensing制御とバイオフィルム形成制御 (2012)
  • Author(s): 池田宰,諸星知広
  • Organizer: 第64回日本生物工学会大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Quorum Sensing制御に基づくバイオフィルム形成制御 (2012)
  • Author(s): 池田宰,諸星知広
  • Organizer: 第61回日本感染症学会東日本地方会・第59回日本化学療法学会東日本支部
  • Place of Presentation: ホテル日航東京
• [Presentation] Enhanced biofilm formation by the bacteria consortium of Microbacterium testaceum and Pantoea agglomerans (2012)
  • Author(s): W. Z. Wang, T. Morohoshi, S. Onuki, N.Someya, T. Ikeda
  • Organizer: 6th ASM Conference on Biofilms, September
  • Place of Presentation: Miami, USA
• [Presentation] Development of innovative regulatory techniques of microbes for wastewatertreatment with quorum sensing regulation (2012)
  • Author(s): T. Ikeda, T. Morohoshi, S. Ito, I.Sawada, N. Kato, K. Iimura, E. Nasuno, H. Uchiyama, N. Nomura, M. Toyofuku
  • Organizer: 第28回日本微生物生態学会大会
  • Place of Presentation: 豊橋科学技術大学
• [Presentation] アルキルアミノ化シクロデキストリンを用いたグラム陰性細菌のQuorum Sensing阻害 (2012)
  • Author(s): 諸星知広,斉藤悠生,伊藤智志,加藤紀弘,池田宰
  • Organizer: 第29回シクロデキストリンシンポジウム
  • Place of Presentation: 星薬科大学
• [Presentation] Phenazine antibiotic production regulated by two quorum sensing systems in Pseudomonas chlororaphis subsp. aurantiaca StFRB508 and its antifungal activity against Phytophthora infestans (2012)
  • Author(s): T. Morohoshi, W. Z. Wang, T. Sutou, N.Someya, T. Ikeda
  • Organizer: The 14th International Symposium onMicrobial Ecology (ISME14)
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] AidC, a novel N-acylhomoserine lactonase from the potato root- associated Chryseobacterium sp. StRB126, a member of Cytophaga- Flavobacteria-Bacteroides (CFB) group (2012)
  • Author(s): W. Z. Wang, T. Morohoshi, N. Someya, T.Ikeda
  • Organizer: The 14th International Symposium on Microbial Ecology (ISME14)
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] 活性汚泥からのアシル化ホモセリンラクトン合成及び分解細菌の単離と機能解析 (2012)
  • Author(s): 諸星知広,篠崎匡広,藤田華嘉,双石彩音,澤田勇生,池田宰
  • Organizer: 環境バイオテクノロジー学会2012年度大会
  • Place of Presentation: 京都大学
• [Presentation] Pantoea ananatisのQuorum Sensingに制御される病原性因子の探索 (2012)
  • Author(s): 諸星知広,菊池健太,緒方優二,上岡夏海,池田宰
  • Organizer: 平成24年度日本植物病理学会大会
  • Place of Presentation: 福岡国際会議場
• [Presentation] グラム陰性細菌のQuorum Sensing制御のための修飾シクロデキストリンの開発 (2012)
  • Author(s): 池田宰,諸星知広,今井拓也,神山拓也,〓名和代,永山勇樹,伊藤智志,加藤紀弘
  • Organizer: 化学工学会第77回年会
  • Place of Presentation: 工学院大学
• [Presentation] ジャガイモ由来Pseudomonas chlororaphis subsp.aurantiacaにおけるフェナジン生産およびクオラムセンシングの解析 (2012)
  • Author(s): 諸星知広,須藤伴範,染谷信孝,池田宰
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都女子大学
• [Presentation] Inhibition of quorum sensing in gram-negative bacteria using electrospun non-woven fiber mats immobilized with cyclodextrins (2012)
  • Author(s): T. Oki, et al.
  • Organizer: The 16th International Cyclodextrin Symposium
  • Place of Presentation: Tianjin, China
• [Presentation] A QCM analysis of the interaction between cyclodextrins and quorum sensing signals produced by gram-negative bacteria (2012)
  • Author(s): N. Kato, et al.
  • Organizer: The 16th International Cyclodextrin Symposium
  • Place of Presentation: Tianjin, China
• [Presentation] Studies of cyclodextrin inclusions complexes with Catechins (2012)
  • Author(s): U. M. Mamenzigou, et al.
  • Organizer: The 16th International Cyclodextrin Symposium
  • Place of Presentation: Tianjin, China
• [Presentation] Inhibition of quorum sensing in Serratia marcescens by forming cyclodextrin-autoinducer complex (2012)
  • Author(s): C. Okano, et al.
  • Organizer: International Conference of Young Researchers on Advanced Materials
  • Place of Presentation: Singapore
• [Presentation] AidC, a novel N-acylhomoserine lactonase from the potato root-associated Chryseobacterium sp. StRB126, a member of Cytophaga-Flavobacteria-Bacteroides (CFB) group (2012)
  • Author(s): W. Z. Wang, et al.
  • Organizer: The 14th International Symposium on Microbial Ecology
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] Phenazine antibiotic production regulated by two quorum sensing systems in Pseudomonas chlororaphis subsp. aurantiaca StFRB508 and its antifungal activity against Phytophthora infestans (2012)
  • Author(s): T. Morohoshi, et al.
  • Organizer: The 14th International Symposium on Microbial Ecology
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] Suppression of the bacterial communication system in opportunistic pathogens using cyclodextrin composites (2012)
  • Author(s): C. Okano, et al.
  • Organizer: IUMRS-ICA2012
  • Place of Presentation: Busan, Korea
• [Presentation] QCM-A法を用いたグラム陰性細菌の細胞間情報伝達分子とシクロデキストリンの相互作用解析 (2012)
  • Author(s): 髙山友理子､他
  • Organizer: 第29回シクロデキストリンシンポジウム
  • Place of Presentation: 星薬科大学
• [Presentation] エレクトロスピニング法で調製したシクロデキストリン固定化高分子ファイバーによるバクテリアのQuorum Sensing機構の遮断 (2012)
  • Author(s): 奈須野恵理
  • Organizer: 第29回シクロデキストリンシンポジウム
  • Place of Presentation: 星薬科大学
• [Presentation] ジャガイモ根由来CFB細菌Chryseobacterium sp.から単離した新規アシル化ホモセリンラクトナーゼの解析 (2012)
  • Author(s): 諸星知広､他
  • Organizer: 第28回日本微生物生態学会大会
  • Place of Presentation: 豊橋技術科学大学
• [Presentation] Development of Innovative Regulatory Techniques of Microbes for Wastewater Treatment with Quorum Sensing Regulation (2012)
  • Author(s): T. Ikeda, et al.
  • Organizer: 第28回日本微生物生態学会大会
  • Place of Presentation: 豊橋技術科学大学
  • Invited
• [Presentation] Development of autoinducer recognition polymers for inhibition of bacterial cell-cell communication and virulence (2012)
  • Author(s): N. Kato, et al.
  • Organizer: The 4th Japan-Korea International Symposium on Microbial Ecology
  • Place of Presentation: 豊橋技術科学大学
  • Invited
• [Presentation] エレクトロスピニング法を用いて調製した高分子ファイバーによるバクテリアの細胞間情報伝達機構の抑制 (2012)
  • Author(s): 梅村拓登、他
  • Organizer: 第22回日本MRS学術シンポジウム
  • Place of Presentation: パシフィコ横浜
• [Presentation] Enhanced biofilm formation by the bacteria consortium of Microbacterium testaceum and Pantoea agglomerans (2012)
  • Author(s): W. Z. Wang, et al.
  • Organizer: 6th ASM Conference on Biofilms
  • Place of Presentation: Miami, USA
• [Presentation] Quorum Sensing制御に基づくバイオフィルム形成制御 (2012)
  • Author(s): 池田宰、他
  • Organizer: 第61回日本感染症学会東日本地方会・第59回日本化学療法学会東日本支部会
  • Place of Presentation: ホテル日航東京
  • Invited
• [Presentation] Pseudomonas chlororaphis subsp. aurantiacaにおけるフェナジン生産制御機構の解析と病原性阻害技術への応用 (2012)
  • Author(s): 諸星知広、他
  • Organizer: 第64回日本生物工学会大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] クオラムセンシング阻害効果を有するシクロデキストリン誘導体の合成 (2011)
  • Author(s): 斉藤悠生, 他
  • Organizer: 第4回臭素化学懇話会年会
  • Place of Presentation: 宇都宮大学
  • Year and Date: 2011-11-25
• [Presentation] Inhibition of biofilm formation and virulence factor expression via control of quorum sensing in pathogenic bacteria (2011)
  • Author(s): T.Ikeda, et al.
  • Organizer: The XVIIth International Symposium on Gnotobiology
  • Place of Presentation: 横浜
  • Year and Date: 2011-11-21
• [Presentation] Diversity and distribution of N-acylhomoserine lacrone (AHL)-degrading activity and AHL-degrading gene (aiiM) in genus Microbacterium (2011)
  • Author(s): W.Wang, et al.
  • Organizer: 4th ASM Conference on Cell-Cell Communication in Bacteria
  • Place of Presentation: Miami, USA
  • Year and Date: 2011-11-07
• [Presentation] Complete genome sequence and characterization of the N-acylhomoserine lactone-degrading gene of the potato leaf-associated Solibacillus silvestris (2011)
  • Author(s): T.Morohoshi, et al.
  • Organizer: 4th ASM Conference on Cell-Cell Communication in Bacteria
  • Place of Presentation: Miami, USA
  • Year and Date: 2011-11-07
• [Presentation] 微生物間の会話を水処理技術へ応用する (2011)
  • Author(s): 池田宰
  • Organizer: 産学交流連携フォーラム
  • Place of Presentation: 栃木県産業振興センター
  • Year and Date: 2011-11-02
• [Presentation] ジャガイモ葉面由来Solibacillus silvestrisからのアシル化ホモセリンラクトン分解遺伝子の単離及び病原性防除への応用 (2011)
  • Author(s): 諸星知広,富永良昭,染谷信孝,池田宰
  • Organizer: 日本農芸化学会関東支部2011年度大会
  • Place of Presentation: 東洋大学
  • Year and Date: 2011-10-15
• [Presentation] 植物感染菌のクォーラムセンシング(QS)とその制御 (2011)
  • Author(s): 池田宰,魚病細菌
  • Organizer: 第18回インターゲノミクスセミナー
  • Place of Presentation: 神戸大学
  • Year and Date: 2011-10-14
• [Presentation] 魚病細菌、植物感染菌のクォーラムセンシング(QS)とその制御 (2011)
  • Author(s): 池田宰
  • Organizer: 第18回インターゲノミクスセミナー
  • Place of Presentation: 神戸大学(招待講演)
  • Year and Date: 2011-10-14
• [Presentation] ジャガイモ根面由来Pseudomonas chlororaphis subsp.aurantiacaにおけるフェナジン生産及びクオラムセンシングの解析 (2011)
  • Author(s): 須藤伴範, 他
  • Organizer: 第27回日本微生物生態学会大会
  • Place of Presentation: 京都大学
  • Year and Date: 2011-10-09
• [Presentation] ジャガイモ葉より単離した非病原性Erwinia属細菌におけるクオラムセンシング機構の解析 (2011)
  • Author(s): 吉塚泰丈, 他
  • Organizer: 第27回日本微生物生態学会大会
  • Place of Presentation: 京都大学
  • Year and Date: 2011-10-09
• [Presentation] イネもみ枯細菌病菌Burkholderia glumaeにおけるpH低下現象およびシュウ酸生産に関わる遺伝子の探索 (2011)
  • Author(s): 加藤太朗, 他
  • Organizer: 第27回日本微生物生態学会大会
  • Place of Presentation: 京都大学
  • Year and Date: 2011-10-09
• [Presentation] N-acylhomoserine lactone-producing or -degrading bacteria isolated from the activated sludge (2011)
  • Author(s): R.Rashid, et al.
  • Organizer: 第27回日本微生物生態学会大会
  • Place of Presentation: 京都大学
  • Year and Date: 2011-10-09
• [Presentation] Development of innovative regulatory techniques of bacteria for wastewater treatment by control of bacterial communication system (2011)
  • Author(s): T.Ikeda, et al.
  • Organizer: The 4th IWA-ASPIRE Conference and Exhibition
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-10-04
• [Presentation] ジャガイモ葉面由来Solibacillus silvestrisStLB046株の全ゲノムシークエンスを元にしたアシル化ホモセリンラクトン分解遺伝子の機能解析 (2011)
  • Author(s): 諸星知広, 他
  • Organizer: 日本生物工学会2011年度大会
  • Place of Presentation: 東京農工大学
  • Year and Date: 2011-09-26
• [Presentation] Quorum Sensing制御に基づくバイオファウリング・バイオフィルム形成制御への取り組み (2011)
  • Author(s): 池田宰
  • Organizer: 先端膜工学研究推進機構23年度秋季膜工学サロン
  • Place of Presentation: 神戸大学
  • Year and Date: 2011-09-21
• [Presentation] Quorum Sensing制御に基づくバイオファウリング・バイオフィルム形成制御への取り組み (2011)
  • Author(s): 池田宰
  • Organizer: 先端膜工学研究推進機構23年度秋季膜工学サロン
  • Place of Presentation: 神戸大学(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] Synthesis of amino modified cyclodextrin for quorum sensing inhibition (2011)
  • Author(s): M.Ebina, et al.
  • Organizer: The 6th Asian Cyclodextrin Conference
  • Place of Presentation: Canberra, Australia
  • Year and Date: 2011-08-29
• [Presentation] Inhibition of quorum sensing in gram-negative bacteria by amino acid-modified cyclodextrins (2011)
  • Author(s): T.Imai, et al.
  • Organizer: The 6th Asian Cyclodextrin Conference
  • Place of Presentation: Canberra, Australia
  • Year and Date: 2011-08-29
• [Presentation] Cyclodextrin complexation of bacterial communication signal compounds (2011)
  • Author(s): M.Mamenzigou, et al.
  • Organizer: The 6th Asian Cyclodextrin Conference
  • Place of Presentation: Canberra, Australia
  • Year and Date: 2011-08-29
• [Presentation] Inhibition of bacterial communication using cyclodextrins (2011)
  • Author(s): T.Ikeda, et al.
  • Organizer: The 6th Asian Cyclodextrin Conference
  • Place of Presentation: Canberra, Australia(招待講演)
  • Year and Date: 2011-08-29
• [Presentation] Degradation of N-acylhomoserine lactone quorum sensing signal molecules by potato root surface-associated Chryseobacterium strains (2011)
  • Author(s): R.Rashid, et al.
  • Organizer: 環境バイオテクノロジー学会2011年度大会
  • Place of Presentation: 東京大学
  • Year and Date: 2011-06-20
• [Presentation] Cell aggregation is regulated by N-acylhomoserine lactone-mediated quorum sensing in the plant pathogen Pantoea ananatis (2011)
  • Author(s): T.Morohoshi, et al.
  • Organizer: Asian Congress on Biotechnology 2011
  • Place of Presentation: Shanghai, China
  • Year and Date: 2011-05-11
• [Presentation] Identification and characterization of a novel class of N-acylhomoserine lactonase from leaf-associated Microbacterium testaceum and the application for quorum qunching (2011)
  • Author(s): W.Wang, et al.
  • Organizer: Asian Congress on Biotechnology 2011
  • Place of Presentation: Shanghai, China
  • Year and Date: 2011-05-11
• [Presentation] Inhibition ofbiofilm formation and virulence factor expression via control of quorum sensing in pathogenic bacteria (2011)
  • Author(s): T. Ikeda, T. Morohoshi
  • Organizer: The XVIIth International Symposium on Gnotobiology
  • Place of Presentation: Yokohama
• [Presentation] Complete genome sequence and characterization of the N-acyl homoserine lactone-degrading gene of the potato leaf-associated Solibacillus silvestris (2011)
  • Author(s): T. Morohoshi, Y. Tominaga, N. Someya, T. Ikeda
  • Organizer: 4th ASM Conference on Cell-Cell Communication in Bacteria
  • Place of Presentation: Miami,USA
• [Presentation] Inhibition of quorum sensing in gram-negative bacteria by modified cyclodextrin derivatives (2011)
  • Author(s): T. Imai, T. Morohoshi, S. Ito, N. Kato, T. Ikeda
  • Organizer: 4th ASM Conference on Cell-Cell Communication in Bacteria
  • Place of Presentation: Miami, USA
• [Presentation] Microbacterium属細菌における新規アシル化ホモセリンラクトン分解遺伝子(aiiM)の多様性と分布 (2011)
  • Author(s): 諸星知広,王文昭,染谷信孝,池田宰
  • Organizer: 第27回日本微生物生態学会大会
  • Place of Presentation: 京都大学
• [Presentation] N-acylhomoserine lactone- producing or -degrading bacteria isolated from the activated sludge (2011)
  • Author(s): R. Rashid, A. Kurabeishi, T. Morohoshi, T. Ikeda
  • Organizer: 第27回日本微生物生態学会大会
  • Place of Presentation: 京都大学
• [Presentation] Development of innovative regulatory techniques of bacteria for wastewater treatment by control of bacterial communication system (2011)
  • Author(s): T. Ikeda, M. Toyofuku, T. Morohoshi, S.Ito, K. Iimura, N. Nomura, H. Uchiyama, N. Kato
  • Organizer: The 4th IWA-ASPIRE Conference and Exhibition
  • Place of Presentation: Tokyo
• [Presentation] ジャガイモ葉面由来olibacillus silvestris StLB046株の全ゲノムシークエンスを元にしたアシル化ホモセリンラクトン分解遺伝子の機能解析 (2011)
  • Author(s): 諸星知広,富永良昭,染谷信孝,池田宰
  • Organizer: 日本生物工学会2011年度大会
  • Place of Presentation: 東京農工大学
• [Presentation] グラム陰性細菌のQuorum Sensing阻害を目指したアミノ酸修飾シクロデキストリンの合成とその機能解析 (2011)
  • Author(s): 今井拓也,諸星知広,加藤紀弘,池田宰
  • Organizer: 第28回シクロデキストリンシンポジウム
  • Place of Presentation: 秋田ビューホテル
• [Presentation] アシル化ホモセリンラクトン分解能を有する修飾シクロデキストリンの合成 (2011)
  • Author(s): 神山拓也,諸星知広,加藤紀弘,池田宰
  • Organizer: 第28回シクロデキストリンシンポジウム
  • Place of Presentation: 秋田ビューホテル
• [Presentation] アミノ化シクロデキストリンのアシル化ホモセリンラクトン包接能の解析 (2011)
  • Author(s): 〓名和代,諸星知広,加藤紀弘,池田宰
  • Organizer: 第28回シクロデキストリンシンポジウム
  • Place of Presentation: 秋田ビューホテル
• [Presentation] Inhibition of bacterial communication using cyclodextrins (2011)
  • Author(s): T. Ikeda, T. Morohoshi, S. Ito, K. Iimura,N. Kato
  • Organizer: The 6th Asian Cyclodextrin Conference (ACC2011)
  • Place of Presentation: Canberra, Australia
• [Presentation] Cyclodextrin complexation of bacterial communication signal compounds (2011)
  • Author(s): U. M. Mamenzigou, T. Morohoshi, S. Ito, N. Kato, T. Ikeda
  • Organizer: The 6th Asian Cyclodextrin Conference (ACC2011)
  • Place of Presentation: Canberra, Australia
• [Presentation] Inhibition of quorum sensing in gram-negative bacteria by aminoacid-modified cyclodextrins (2011)
  • Author(s): T. Imai, T. Morohoshi, N. Kato, T. Ikeda
  • Organizer: The 6th Asian Cyclodextrin Conference (ACC2011)
  • Place of Presentation: Canberra, Australia
• [Presentation] Synthesis of amino modified cyclodextrin for quorum sensing inhibition (2011)
  • Author(s): M. Ebina, T. Morohoshi, N. Kato, T. Ikeda
  • Organizer: The 6th Asian Cyclodextrin Conference (ACC2011)
  • Place of Presentation: Canberra, Australia
• [Presentation] Degradation of N-acylhomoserine lactone quorum sensing signal molecules by potato root surface-associatedChryseobacterium strains (2011)
  • Author(s): R. Rashid, T. Morohoshi, N. Someya, T.Ikeda
  • Organizer: 環境バイオ テクノロジー学会2011年度大会
  • Place of Presentation: 東京大学
• [Presentation] Identification and characterization of a novel class of N-acylhomoserine lactonase from leaf-associated Microbacterium testaceum and the application for quorum qunching (2011)
  • Author(s): W. Z. Wang, M. Ikenoya, T. Morohoshi, N.Someya, T. Ikeda
  • Organizer: Asian Congress on Biotechnology 2011 (ACB-2011)
  • Place of Presentation: Shanghai, China
• [Presentation] Cell aggregation is regulated by N-acylhomoserine lactone-mediated quorum sensing in the plant pathogen Pantoea ananatis (2011)
  • Author(s): T. Morohoshi, Y. Ogata, T. Ikeda
  • Organizer: Asian Congress on Biotechnology 2011 (ACB-2011)
  • Place of Presentation: Shanghai, China
• [Presentation] Inhibition of quorum sensing using cyclodextrins (2010)
  • Author(s): T. Ikeda, T. Sato, T. Imai, T. Kamiyama, M. Mamenzigou, S. Ito, T. Morohoshi, N. Kato
  • Organizer: 2010International Chemical Congress ofPacific Basin Societies (Pacifichem2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Inhibition of the pathogenicity of Serratia marcescens by the synthetic analog of quorum-sensing signal molecule (2010)
  • Author(s): T. Morohoshi, T. Shiono, K. Takidouchi,N. Kato, and T. Ikeda
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Quorum quenching using two kinds of novel inhibitors, AHL analogues and modified cyclodextrins, in gram-negative bacteria (2010)
  • Author(s): W. Z. Wang, T. Sato, S. Ito, N. Kato, T.Morohoshi, T. Ikeda
  • Organizer: International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: 2010 (Honolulu, USA)
• [Presentation] Construction of a biosensor based on the purple pigment production of Chromobacterium violaceum for the detection of the quorum-sensing signal molecules (2010)
  • Author(s): Y. Yoshizuka, T. Morohoshi, T. Ikeda
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Quorum sensing quenching in gram-negative bacteria using modified cyclodextrins (2010)
  • Author(s): T. Imai, T. S. Ito, T. Morohoshi, N. Kato, T. Ikeda
  • Organizer: 2010 International Chemical Congress of Pacific BasinSocieties (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] ジャガイモ根面からの新規アシル化ホモセリンラクトン分解細菌の単離と機能解析 (2010)
  • Author(s): 諸星知広,Rumana Rasid,池野谷仁,染谷信孝,池田宰
  • Organizer: 第26回日本微生物生態学会大会
  • Place of Presentation: 筑波大学
• [Presentation] バレイショ葉面菌Microbacterium testaceum由来アシル化ホモセリンラクトン分解遺伝子のクローニングと機能解析 (2010)
  • Author(s): 池野谷仁,王文昭,諸星知広,染谷信孝,池田宰
  • Organizer: 日本生物工学会2010年度大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] アミノ酸修飾シクロデキストリンによるグラム陰性細菌のQuorum Sensing阻害に関する研究 (2010)
  • Author(s): 今井拓也,諸星知広,加藤紀弘,池田宰
  • Organizer: 第27回シクロデキストリンシンポジウム
  • Place of Presentation: 金沢市文化ホール
• [Presentation] 修飾シクロデキストリンによるアシル化ホモセリンラクトン分解に関する研究 (2010)
  • Author(s): 神山拓也,諸星知広,加藤紀弘,池田宰
  • Organizer: 第27回シクロデキストリンシンポジウム
  • Place of Presentation: 金沢市文化ホール
• [Presentation] Control methods of quorum sensing ingram-negative bacteria using cyclodextrins (2010)
  • Author(s): T. Ikeda, S. Ito, T. Morohoshi, N. Kato
  • Organizer: 2010 International Symposium on Advanced Biological Engineering
  • Place of Presentation: Beijing, China
• [Presentation] Identification of N-acylhomoserine lactonase from Microbacterium testaceum and its application for quorum quenching (2010)
  • Author(s): W. Z. Wang, M. Ikenoya, T. Morohoshi, N.Someya, T. Ikeda
  • Organizer: 2010International Symposium on AdvancedBiological Engineering
  • Place of Presentation: Beijing, China
• [Presentation] Rumana Rasid,池野谷仁,染谷信孝,池田宰,植物表面からのアシル化ホモセリンラクトン分解細菌の探索と応用 (2010)
  • Author(s): 諸星知広,王文昭
  • Organizer: 環境バイオテクノロジー学会2010年度大会
  • Place of Presentation: 東北大学
• [Presentation] Inhibiton of quorum sensing in gram-negative bacteria using modified cyclodextrins (2010)
  • Author(s): T. Ikeda, T. Sato, M. Mamenzigou, T. Imai, T. Kamiyama, S. Ito, T. Morohoshi, N. Kato
  • Organizer: 15th International Cyclodextrin Symposium
  • Place of Presentation: Vienna, Austria
• [Presentation] Inhibiton of quorum sensing in gram-negative bacteria using modified cyclodextrins (2010)
  • Author(s): T.Ikeda, T.Saco, M.Mamenzigou, T.Imai, T.Kamiyama, S.Ito, T.Morohoshi, N.Kato
  • Organizer: 15th Intenational Cyclodextrin Symposium
  • Place of Presentation: Venna, Austria
• [Presentation] Suppressive effects on virulence factor expression with structural control of cvclodextrin-immobilized gel (2010)
  • Author(s): N.Kato, A.Kobayashi, H.Motohashi, T.Murai, T.Morohoshi, T.Ikeda
  • Organizer: 15th Intenational Cyclodextrin Symposium
  • Place of Presentation: Vienna, Austria
• [Presentation] 植物表面からのアシル化ホモセリンラクトン分解細菌の探索と応用 (2010)
  • Author(s): 諸星知広, 王文昭, Rumana Rasid, 池野谷仁, 染谷信孝, 池田宰
  • Organizer: 環境バイオテクノロジー学会2010年度大会
  • Place of Presentation: 東北大学
• [Presentation] Control methods of quorum sensing in gram-negative bacteria using cyclodextrins (2010)
  • Author(s): T.Ikeda, S.Ito, T.Morohoshi, N.Kato
  • Organizer: 2010 International Symposium on Advanced Biological Engineering
  • Place of Presentation: Beijing, China
• [Presentation] Identification of N-acylhomoserine lactonase from Microbacterium testaceum and its application for quorum quenching (2010)
  • Author(s): W-Z.Wang, M.Ikenoya, T.Morohoshi, N.Someya, T.Ikeda
  • Organizer: 2010 International Symposium on Advanced Biological Engineering
  • Place of Presentation: Beijing, China
• [Presentation] Identification and characterization of the transposon mutants, which produce excessive extracellular polysaccharide in Pantoea ananatis (2010)
  • Author(s): Y.Xu, M.Masukawa, T.Morohoshi, T.Ikeda, Y.Li
  • Organizer: 2010 Intenational Symposium on Advanced Biological Engineering
  • Place of Presentation: Beijing, China
• [Presentation] アミノ酸修飾シクロデキストリンによるグラム陰性細菌のQuorm Sensing阻害に関する研究 (2010)
  • Author(s): 今井拓也, 諸星知広, 加藤紀弘, 池田宰
  • Organizer: 第27回シクロデキストリンシンポジウム
  • Place of Presentation: 金沢市文化ホール
• [Presentation] 植物病原菌Pantoea ananatisにおける菌体凝集のクオラムセンシングによる制御 (2010)
  • Author(s): 緒方優二, 諸星知広, 池田宰
  • Organizer: 日本生物工学会2010年度大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] 食虫植物ウツボカズラ消化液内共生細菌メタゲノムライブラリーからの新規リパーゼ遺伝子のスクリーニング (2010)
  • Author(s): 及川学, 佐藤祥子, 諸星知広, 池田宰
  • Organizer: 日本生物工学会2010年度大会
  • Place of Presentation: 宮崎シーガイア
• [Presentation] バレイショ葉面菌Microbacterium testaceum由来アシル化ホモセリンラクトン分解遺伝子のクローニングと機能解析 (2010)
  • Author(s): 池野谷仁, 王文昭, 諸星知広, 染谷信孝, 池田宰
  • Organizer: 日本生物工学会2010年度大会
  • Place of Presentation: 官崎シーガイア
• [Presentation] Inhibition of quorum sensing using cyclodextrins (2010)
  • Author(s): T.Ikeda, T.Sato, T.Imai, T.Kamiyama, M.Mamenzigou, S.Ito, T.Morohoshi, N.Kato
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Inhibition of the pathogenicity of Serratia marcescens by the synthetic analog of quorum-sensing sienal molecule (2010)
  • Author(s): T.Morohoshi, T.Shiono, K.Takidouchi, N.Kato, T.Ikeda
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Quorum quenching using two kinds of novel inhibitors, AHL analogues and modified cyclodextrins, in gram-negative bacteria (2010)
  • Author(s): W-Z.Wang, T.Sato, S.Ito, N.Kato, T.Morohoshi, T.Ikeda
  • Organizer: 2010 Intenational Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Construction of a biosensor based on the purple pigment production of Chromobacterium violaceum for the detection of the quorum-sensing signal molecules (2010)
  • Author(s): Y.Yoshizuka, T.Morohoshi, T.Ikeda
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu,USA
• [Presentation] The production of carotenoid pigments is regulated by acylhomoserine lactone-mediated quorum sensing in Pantoea ananatis (2010)
  • Author(s): N.Kamioka, T.Morohoshi, T.Ikeda
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] Quorum sensing quenching in gram-negative bacteria using modified cyclodextrins (2010)
  • Author(s): T.Imai, S.Ito, T.Morohoshi, N.Kato, T.Ikeda
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] 継代培養中に出現するBurkholderiaglumaeのコロニー変異菌における培養液pHとQuorum Sensing物質N-Acyl Homoserine Lactone蓄積量について (2009)
  • Author(s): 加藤太朗, 諸星知広, 封馬誠也, 池田宰
  • Organizer: 平成22年度日本植物病理学会関東部会
  • Place of Presentation: 文科省研究交流センター
• [Remarks]
  • URL: http://www.chem.utsunomiya-u.ac.jp/lab/bio/
• [Remarks] 生物工学研究室 -宇都宮大学大学院工学研究科-
  • URL: http://www.chem.utsunomiya-u.ac.jp/lab/bio/
• [Remarks]
  • URL: http://www.chem.utsunomiya-u.ac.jp/lab/bio/
• [Remarks]
  • URL: http://www.chem.utsunomiya-u.ac.jp/lab/bio/