The development of degradation methods of signal compounds in bacterial cell-cell communication mechanism for the inhibition of the biofilm formation
| Project/Area Number |
22510081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental technology/Environmental materials
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| Research Institution | Utsunomiya University |
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Principal Investigator |
IKEDA Tsukasa 宇都宮大学, 大学院・工学研究科, 教授 (40151295)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | バイオフィルム / バクテリア / 細胞間情報伝達機構 / クォーラムセンシング / ア シル化ホモセリンラクトン / 阻害剤 / アシル化ホモセリンラクトン分解酵素 / 遺伝子発現制御 / N-アシル-L-ホモセリンラクトン / AHL分解酵素 / AHL分解酵 / バイオフィル / N-アシル-L-ホモセリンラクトン(AHL) |
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| Research Abstract |
The inhibitory methods of bacterial cell-cell communication mechanism regulates a biofilm formation have been developed for the inhibition of the biofilm formation which causes a lot of environmental and medical problems. Various natural enzymes degrade signal compounds in bacterial cell-cell communication mechanism has been obtained and their usefulness for the inhibition of the biofilm formation has been confirmed. Moreover, the new chemical methods for the trap and/or degrade signal compounds in bacterial cell-cell communication mechanism have been also developed and their usefulness for the inhibition of the biofilm formation has been also confirmed.
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Report
(4 results)
Research Products
(127 results)
